SOVREMENNAYA PEDIATRIYA.2016.2(74):15-21; doi 10.15574/SP.2016.74.15 

The use of micronutrient complexes in pediatrics: the benefits and potential risks 

Mamenko M. E.

P.L. Shupyk National Medical Academy of Postgraduate Education, Kiev, Ukraine 

The feasibility of multiple-micronutrient supplementation in pediatric practice is discussed in the article. It concerns the problems of the necessity of the balanced nutrition for the body of the child, the impact of its imbalance on the development of nutritional disorders and nutrition dependent diseases. The causes of high prevalence of micronutrient deficiency in the world today are analyzed in the article. The WHO national strategies for the prevention micronutrient deficiency and individual prophylactic methods are mentioned. Particular attention is paid to the feasibility and safety of complexes of micronutrients (vitamins and minerals), the criteria for their prescribing for children of different ages and with different functional activity of the body. 

Key words: vitamins; minerals; micronutrients; food; children. 

REFERENCES

1. Bezler ZhA. 2009. Defitsit vitaminov i mineralov u detey: sovremennyie metodyi profilaktiki. Ucheb-metod posobie. Minsk: BGMU: 66.

2. Demin VF. 2007. Lektsii po pediatrii: dietologiya i nutritsiologiya. Moskva. 7: 395.

3. Detskoe pitanie. Rukovodstvo dlya vrachey. Pod red VA Tutelyana, IYa Konya. 3-e izd, pererab i dop. Moskva: Med. inform. ag. 2013: 744.

4. Zaharova IN, Svintsitskaya VI. 2010. Primenenie vitaminov-antioksidantov v pediatricheskoy praktike. Lechaschiy vrach. 8: 45—47.

5. Volosovets AP, Krivopustov SP, Cherniy EF i dr. 2012. K voprosu o roli tsinka v klinicheskoy pediatrii. Dityachiy likar. 5(18): 37—39.

6. Kvashnina LV. 2013. Immunomoduliruyuschie effektyi vitamina D u detey. Zdorove rebenka. 7(50).

7. Korzhynskyi YuS, Lisnyi AIe. 2009. Rol tsynku v normi ta pry patolohii. Zdorovia dytyny. 1(16): 52—57.

8. Korovina NA, Zaharova IN, Svintsitskaya VI. 2006. Defitsit zheleza i kognitivnyie rasstroystva u detey. Lechaschiy vrach. 5: 69—71.

9. Lapshin VF. 2007. Modern principles of vitamin:based prevention and vitamin therapy administration in children age. Sovremennaya pediatriya. 1: 100—105.

10. Mamenko M.E. 2010. Iodine deficiency prevention (revisited the necessity of application of national program). Sovremennaya pediatriya. 2: 39—45.

11. Mohireva LV, Bogadelnikova IV. 2011. Biologicheskaya rol tsinka v organizme cheloveka. Tuberkulez i bolezni legkih. 7: 62—57.

12. Nadraha OB, Potsiluiko NM. 2011. Preparaty tsynku v kompleksnomu likuvanni hostrykh diarei u ditei. Zdorovia dytyny. 4(31): 32—37.

13. Namazova LS, Torshoeva RM, Gromov IA i dr. 2008. Primenenie polivitaminov u detey s allergicheskimi boleznyami. Voprosyi sovremennoy pediatrii. 7; 1: 126—128.

14. Sait VOOZ. Departament z pytan kharchuvannia http://www.who.int/nutrition/challenges/ru/

15. Spirichev VB. 2007.Vitaminyi i mineralnyie veschestva v pitanii i podderzhanii zdorovya detey. Moskva: Valetek: 24.

16. Talashova SV. 2009. Correction of vitamin and mineral state in schoolchildren in autumn. Perinatologiya i pediatriya. 4(40): 84—86.

17. Shadrin OG, Dyukareva-Bezdenezhnyih SV. 2011. Puti povyisheniya effektivnosti lecheniya bronholegochnyih zabolevaniy u detey rannego vozrasta. Zdorove rebenka. 1(28).

18. Kosuke K et al. 2010. A randomized trial to determine the optimal dosage of multivitamin supplements to reduce adverse pregnancy outcomes among HIV-infected women in Tanzania. American Journal of Clinical Nutrition. 91: 391—7. http://dx.doi.org/10.3945/ajcn.2009.28483; PMid:19939985 PMCid:PMC2806894

19. Christian P et al. 2005. Antenatal micronutrient supplements in Nepal. The Lancet. 366(9487): 711—2. http://dx.doi.org/10.1016/S0140-6736(05)67166-8

20. Ba H, Bhutta ZA. 2006. Multiplemicronutrient supplementation for women during regnancy. Cochrane Database of Systematic Reviews. 4.

21. Batool A. Haider, Zulfiqar A. Bhutta. 2015, Nov. Multiplemicronutrient supplementation for women during pregnancy. Cochrane Database of Systematic Reviews. Online Publication Date: November 2015. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004905.pub4/full

22. Clifford RL, Knox AJ. 2009. Vitamin D — a new treatment for airway remodelling in asthma? Br J Pharmacol. 158(6): 1426—8. http://dx.doi.org/10.1111/j.1476-5381.2009.00429.x; PMid:19906117 PMCid:PMC2795209

23. Combs FGJr. 2008. The vitamins. Fundamental aspects in nutrition and health. 3-rd ed. Amsterdam-Boston: Elsevier Academic Press: 584.

24. Shankar AH et al. 2008. Effect of maternal multiple micronutrient supplementation on fetal loss and infant death in Indonesia: a double-blind cluster-randomised trial. The Lancet. 371(9608): 215—27. http://dx.doi.org/10.1016/S0140-6736(08)60133-6

25. Bhandari N, Mazumder S, Taneja S et al. 2008. Effectiveness of zinc supplementation plus oral rehydration salts compared with oral rehydration salts alone as a treatment for acute diarrhea in a primary care setting: a cluster randomized trial. Pediatrics. 121. http://dx.doi.org/10.1542/peds.2007-1939

26. De-Regil LM, Pena-Rosas JP, Fernandez-Gaxiola AC, Rayco-Solon P. 2015, Dec. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database of Systematic Reviews. Online Publication Date: December 2015. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007950.pub3/full

27. Expert Group on vitamins and minerals. Safe upper levels for vitamins and minerals Food Standards Agency 2003: London UK.

28. Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes. Zohra S. Lassi, Rehana A. Salam, Batool A. Haider, Zulfiqar A. Bhutta. Online Cochrane Database of Systematic Reviews. Publication Date: March 2013 http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD006896.pub2/full

29. Ginde AA, Mansbach JM, Camargo CA. 2009. Vitamin D, respiratory infections, and asthma. Jr Curr Allergy Asthma Rep. 9(1): 81—87. http://dx.doi.org/10.1007/s11882-009-0012-7

30. Haider BA, Bhutta ZA. 2006. Multiplemicronutrient supplementation for women during pregnancy. Cochrane Database of Systematic Reviews. Issue 4. Art. No.: CD004905; http://dx.doi.org/10.1002/14651858.CD004905.pub2.

31. Lazzerini M, Ronfani L. 2008. Oral zinc for treating diarrhea in children. Cochrane Database Syst Rev: CD 005436.

32. Papathakis PC et al. 2007. Micronutrient status during lactation in HIV-infected and HIV-uninfected South African women during the first 6 mo after delivery. American Journal of Clinical Nutrition. 85(1): 182—92. PMid:17209195

33. Drain PK et al. 2007. Micronutrients in HIV-positive persons receiving highly active antiretroviral therapy. American Journal of Clinical Nutrition. 85(2): 333—45. PMid:17284727

34. Fawzi WW et al. 2007. Multivitamin supplementation improves hematologic status in HIV-infected women and their children in Tanzania. American Journal of Clinical Nutrition. 85(5): 1335—43. PMid:17490971

35. Parminder S. Suchdev, Juan Pablo Pena-Rosas, Luz Maria De-Regil. 2015, June. Multiple micronutrient powders for home (point-of-use) fortification of foods in pregnant women. Cochrane Database of Systematic Reviews. Online Publication Date: June 2015. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011158.pub2/full

36. Pena-Rosas J, Viteri F. 2009. Effects and safety of preventive oral iron or iron-folic acid supplementation for women during pregnancy. Cochrane Database of Systematic Reviews. 4. http://dx.doi.org/10.1002/14651858.cd004736.pub3

37. Brehm JM, Schuemann B, Fuhlbrigge AL et al. 2010. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol. 126(1): 52—5. http://dx.doi.org/10.1016/j.jaci.2010.03.043; PMid:20538327 PMCid:PMC2902692

38. Shrimpton DH. 2002. RDAs — what do they really mean? The Pharmaceutical Journal. 268: 365—366.

39. Vitamin and Mineral Nutrition Information System. Geneva: World Health Organization, 2009.

40. Walker CL, Black RE. 2010.Zinc for the treatment of diarrhoae: effect on diarrhoea morbidity, mortality and incidence of future episodes. International Epidemiological association,

41. Zimmermann MB. 2009. Iodine Deficiency. Endocrine Reviews. 30(4): 376—408. http://dx.doi.org/10.1210/er.2009-0011; PMid:19460960