SOVREMENNAYA PEDIATRIYA.2016.3(75):94-96; doi10.15574/SP.2016.75.94 

Experience of vitamin D3 combined therapy in atopic dermatitis in children 

Selska Z. V.

Bogomolets national medical university, Kyiv, Ukraine 

Purpose. To investigate the efficacy of vitamin D₃ in the treatment of atopic dermatitis in children.

Materials and methods. We examined 42 children with atopic dermatitis. In 7 (16.7±5.8%) children had mild atopic dermatitis, 22 (52.4±7.7%) children had moderate severity of the disease, and 13 (31.0±7.1%) children diagnosed with severe degree of illness. Patients were aged 3 to 16 years. Definition 25(OH)D was performed using elektrochemiluminestsencysi method.

Results. Average indicator of vitamin 25(ОН)D in the blood serum of children with atopic dermatitis to the vitamin D ingestion was 19.63 ng/ml (Me=19.63; Q1=12.90; Q3=22.17), and after taking cholecalciferol — 29.13 ng/ml (Me=29.13; Q1=22.71; Q3=31.15). To improve therapeutic benefit to children with atopic dermatitis was appointed higher doses of cholecalciferol — 4000 IU daily during remission and 5.000 IU daily during exacerbation rate of 2 months in the complex therapeutic measures applied in remission and exacerbation. After receiving vitamin D average 25(ОН)D was 42.44 ng/ml (Me=42.44; Q1=40.23; Q3=58.75). In no child is determined by the level of 25(OH)D in the serum that exceeded normal values (>80 ng/ml) and there was no clinical signs of hypervitaminosis. After prolonged use of cholecalciferol in children with atopic dermatitis was noted facilitate disease.

Conclusions. Thus, the results indicate that there is a correlation between the development of atopic dermatitis in children and the level of 25(OH)D in the serum in them. In view of the findings can be considered that children with atopic dermatitis should be prescribed vitamin D3 all year, except summer months, adding treatment to the disease.

Key words: children, atopic dermatitis, treatment, vitamin D.

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