SOVREMENNAYA PEDIATRIYA.2016.1(73):131-136; doi10.15574/SP.2016.73.131 

Metabolic therapy and its role in the complex treatment of connective tissue dysplasia in Pediatric Nephrology 

Nyan'kovskyi S. L., Dobrik O. O., Іs'kiv M. Yu.

Danylo Galytskyi Lviv National Medical University, Ukraine 

Objective: to improve the diagnostics and treatment of connective tissue dysplasia in patients with nephrology pathology children. 

Patients and methods. A total of 40 children in the age from 2 to 18 years with infectious and inflammatory diseases of the urinary tract and the clinical symptoms of undifferentiated connective tissue dysplasia (NDCTD) were under observation. The main group consisted of 20 children with underweight (less than the 25th percentile), and loss of appetite. The control group consisted of 20 children with a body weight within the 25-75 percentiles. All children of the main group additionally applicated «Trimetabol» in the age dose for 30 days. 

Results. The frequency of clinical manifestations of the NDCTD in children of the both groups was similar and had no statistically significant differences. In a significant proportion of children of the both groups were observed manifestations of asthenic-neurotic syndrome and vegetative-visceral dysfunction. Due to the treatment was improved the condition of children in both groups, but more pronounced positive dynamics were observed in children of the main group, which received Trimetabol in the complex therapy. The positive effect of preparation was confirmed by laboratory parameters. 

Conclusions. The use of Trimetabol in the therapy of the NDCTD had a positive effect on the general condition and well-being of children through an integrated action of the components of the preparation. The results of examination certify about sufficient clinical efficacy, safety and tolerability of «Trimetabol» in children with clinical manifestations of the NDCTD and infectious and inflammatory diseases of the urinary tract. 

Key words: connective tissue dysplasia, children's nephrology, hydroxyproline. 

REFERENCES

1. Bakalyuk O. Y. NefrologIya dlya sImeynogo lIkarya. TernopIl, Ukrmedkniga. 2003: 440.

2. Veltischev YuE. 1986. Puti sovershenstvovaniya metodov profilaktiki nasledstvennyih zabolevaniy i ohranyi zdorov'ya detey. Pediatriya. 8: 3—8.

3. Zaharova IN, Skorobogatova EV, Obyinochnaya EG i dr. 2007. Defitsit vitaminov i mikroelementov u detey i ih korrektsiya. Pediatriya. 3: 112—118.

4. Displazii soedinitelnoy tkani. Materialyi simpoziuma. Pod red GI Nechaevoy. Omsk, OPMA. 2002: 168.

5. Ivanov DD. 2011. InfektsIYi sechovoYi sistemi u dItey. Dityachiy lIkar. 2: 12—14.

6. Kadurina TI, Gorbunova VI. 2009. Displaziya soedinitelnoy tkani. Rukovodstvo dlya vrachey. Sankt-Peterburg, Elbi-SPb: 704.

7. Kaldyibekova AA. 2008. Osobennosti vtorichnogo pielonefrita u detey na fone nedifferentsirovannoy dispdazii soedinitelnoy tkani. Avtoref dis kand med nauk. Ekaterinburg: 31.

8. Nazarenko LG. 2010. DisplazIya spoluchnoYi tkanini: rol v patologIYi lyudini I problemah gestatsIynogo perIodu. ZhInochiy LIkar. 1: 42—48.

9. Omelchenko LI, Nikolaenko VB. 2004. Displazii soedinitelnoy tkani u detey. Doctor. 1: 44—47.

10. Rebrov VG, Gromova OA. 2003. Vitaminyi i mikroelementyi. Moskva, Alev-V: 648.

11. Sergeeva KM, Smirnova NN. 2000. Vtorichnyie nefropatii u detey. Diagnostika i printsipyi lecheniya. Nefrologiya. 4; 2: 19—23.

12. Sinitska VO, Pavlishin GA, Chubata OB. 2008. MetabolIchna terapIya v kompleksnomu lIkuvannI sindromu displazIYi spoluchnoYi tkanini u dItey. Mistetstvo lIkuvannya. 8: 89—91.

13. Sultanov AT, Rozhkova SN, Salihova MZ ta In. 2013.Snizhennyiy appetit i ego korrektsiya. Pediatriya. 3: 59—61.

14. Churilina AV, Moskalyuk ON. 2006. Narushenie metabolizma soedinitelnoy tkani pri nekotoryih patologicheskih sostoyaniyah u detey. Zdorove rebenka. 1: 122—126.

15. Eaton S, Bartlett K, Pourfarzam M. 1996. Mammalian mitochondrial bGoxidation. Biochem J. 320: 345—357. http://dx.doi.org/10.1042/bj3200345; PMid:8973539 PMCid:PMC1217938