Antibiotic-associated diarrhea in outpatient children receiving antibiotic therapy

Kozhevin R. V. 
Odessa State Medical University

Purpose: to assess an incidence of diarrhea among children taking an oral antibiotics; identify risk factors for its occurrence.

Patients and methods: the study was conducted during 16 months on the basis of the polyclinic department in Odessa region children's hospital among 1–17 years children. The study took place during the first visit with an appointment of antibiotic therapy in an ambulant conditions. The basis for the diagnosis an antibiotic"associated diarrhea was the appearance of a soft or watery stool at least three times a day for two successive days. As the studied factors there were taken into account child's age, medical history (previous treatment, chronic, allergic or other diseases); the base disease with an antimicrobial drug; a kind of antibiotic, the duration of appointment. The statistical analysis of the data was performed using STATISTICA 7.0 packages and Microsoft EXCEL 2003 with the program integration AtteStat 13. 5, inet-calculation SISA (Simple Interactive Statistical Analysis).

Results: the incidence of antibiotic"associated diarrhea among children who were in ambulant treatment, was 11.4%. The appearance of diarrhea noted at 5.8±2.7 days of therapy. Duration AAD averaged 4.3±1.3 days. Children under 3 years are 3 times greater chance of diarrhea compared with other age periods.

Conclusions: Prior use of antibiotics, amoxicillin, clavulanic acid protected identified as significant risk factors for AAD. Children who took probiotic preparations since the start of antibiotic therapy had a significantly lower chance of developing AAD.

Key words: antibiotic-associated diarrhea, probiotic preparations, children.

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