PERINATOLOGIYA I PEDIATRIYA.2014.1(57):105-108; doi 10.15574/PP.2014.57.105 
 

Clinical and laboratory criteria for the efficiency of early rehabilitation treatment in preterm infants with hypoxic damage of the central nervous system

Kislova Y. A., Mazulov A. V., Sergeta D. P., Kondratyuk E. Yu. 

M.I. Pirogov Vinnitsya National Medical University, Vinnitsya, Ukraine

Vinnitya Regional Children's Clinical Hospital, Vinnitsya, Ukraine

Objective — to evaluate the effectiveness of the complex of early preventive measures with the use of neuroprotective therapy (citicoline) and stimulating massage in preterm infants with hypoxic damage of the central nervous system (CNS).

Patients and methods. In the study group were included 36 infants with gestational age less than 34 weeks with the presence of hypoxic damage of the CNS. For the treatment of these infants was used preparation citicoline, designed primarily to normalize the functioning of the cell membrane of neurons and also early stimulating massage. The effectiveness of early rehabilitation treatment in preterm infants was evaluated by the level of psychomotor development by Bailey test scales in the post'conceptual age of 37 weeks and up to the age of 18 months and with the value of neuron specific enolase (NSE) in the blood serum on 5-7th day of life and in the dynamics of the 4th week of life.

Results. Established medical efficacy of early application of neuroprotective therapy in combination with not medical influence in preterm infants with hypoxic damage of the CNS as evidenced by the improvement of neurological symptoms, an increase in the rate of psychomotor development in the corrected age of 18 months, the decline in the level of neuron specific enolase as a marker of neuronal destruction.

Conclusions. Introduction of neuroprotectant — citicoline to the complex of preventive measures by the course of 3 months additionally with conducting of early massages (from the 10th day of life and/or up to post'conceptual age of 32 weeks in preterm infants) promotes improvement of the rate of neurological status.

Key words: hypoxic damage of the central nervous system, premature infants, citicoline, neyronspetsifichna enolase, Bailey test.

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