PERINATOLOGIYA I PEDIATRIYA.2014.1(57):90-93; doi 10.15574/PP.2014.57.90 

Anallysis of risk factors of atopic dermatitis in infants

Ariaev N. L., Shevchenko I. M., Titkova E. V.

Odessa State Medical University, Ukraine

Objective: To study the risk factors which are determine the development of atopic dermatitis (AD) in infants and identify the most significant from them.

Patients and methods. During the study were examined medical records and interviewed relatives of 47 children with varying severity of AD (main group). The control group consisted of 55 apparently healthy children in which risk factors were also analyzed. Statistical analysis of the results is carried out using the package of STATISTICA 7.0 and SISA internet calculator (Simple Interactive Statistical Analysis). Data mining was used with the aim to identify patterns among a large number of qualitative features.

Results. The most significant factors that increase the risk of blood pressure in children in the first year of life are allergic disease in mothers (c²=24.04, p=0.000001), TORCH-infections (c²=9.93, p=0.001) and fungal vaginitis (c²=6.44, p=0.01). In the group of patients with AD mothers in 11 times more likely suffering from allergies (OR=-11.36, 95% CI-2.42-16.46 ) and also in 11 times more frequently in this group observed allergic diseases in the immediate family (OR 11, 07, 95% CI 1.30–249.65). These figures confirm the high incidence of genetic risk of AD in children.

Conclusions. Taking into account the high risk of debut AD in infants at the presence of TORCH-infections, fungal vaginitis and chronic diseases of the gastrointestinal tract in mothers should be paid attention to the prevention and timely treatment of these pathological processes.

Key words: atopic dermatitis, risk factors, infants.

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