• Features of microcirculation state and endothelial function of microvessels in pregnant women with gestational diabetes 
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Features of microcirculation state and endothelial function of microvessels in pregnant women with gestational diabetes 

PERINATOLOGIYA I PEDIATRIYA.2015.4(64):15-18; doi 10.15574/PP.2015.64.15 
 

Features of microcirculation state and endothelial function of microvessels in pregnant women with gestational diabetes 
 

Goncharenko N. I.

SI «Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine», Kiev 
 

Objective: to determine endothelium function state at the level of vessels of microvasculature in pregnant women with gestational diabetes. 
 

Patients and methods. The study included 24 pregnant women with gestational diabetes. The control group consisted of 20 pregnant women who did not have chronic diseases. The studies of vessels of microvasculature were conducted using the method of laser doppler flowmetry with the use of «LAKK-02.» 
 

Results. It is found that for gestational diabetes is typical involvement of vessels of microvasculature to the pathological process with the change of endothelial function. 
 

Conclusions. Application of the laser doppler flowmetry method allows reveals a violation of microcirculation and endothelial dysfunction at the level of microvessels. 
 

Key words: gestational diabetes, vessels of microvasculature, laser doppler flowmetry. 
 

REFERENCES

1. Рагозин АК, Арбатская НЮ, Демидова ИЮ и др. 2010. Гестационный сахарный диабет: патогенез, диагностика, протокол ведения. Эффективная фармакотерапия. 5—6: 12—21.

2. Лазерная допплеровская флоуметрия микроциркуляции крови. Под ред АИ Крупаткина, ВВ Сидорова. Москва, Медицина. 2005: 254.

3. Karoli R, Siddiqi Z, Fatima J et al. 2015. Assessment of noninvasive risk markers of subclinical atherosclerosis in premenopausal women with previous history of gestational diabetes mel) litus. Official Journal of the Gulf Heart Association. 16(1): 13—18.

4. Alatab S, Fakhrzadeh H, Sharifi F et al. 2013. Correlation of serum homocysteine and previous history of gestational diabetes mellitus. Journal of Diabetes & Metabolic Disorders. 12: 34.

5. Deanfield JE, Halcox JP, Rabelink TJ. 2007. Endothelial Function and Dysfunction. Circulation. 115: 1285—1295.

6. Salomon C, Westermeier F, Casanello P et al. 2010. Differential modulation of insulin receptor isoforms expression and NOS activity by insulin in human placenta microvascular endothelial cells from gestational diabetes. Placenta. 31: A-80.

7. Sobrevia L, Salomon C, Westerneir F et al. 2011. Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes. Placenta. 32: 159—164.

8. Escudero C, Casanello P, Sobrevia L. 2008. Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from preeclampsia. Placenta. 29: 816—825.

9. Leiva А, Pardo F, Ramirez MA et al. 2011. Fetoplacental vascular endothelial dysfunction as an early phenomenon in the programming of human adult diseases in subjects born from gestational diabetes mellitus or obesity in pregnancy. Exp Diabetes Res. 3: 49—286.

10. Hanna F, Peters J, Harlow J et al. 2008. Gestational diabetes screening and glycaemic management; national survey on behalf of the Association of British Clinical Diabetologists. QJM. 101: 777.

11. Gunderson EP, Chiang V, Pletcher MJ. 2014. History of Gestational Diabetes Mellitus and Future Risk of Atherosclerosis in Midlife: The Coronary Artery Risk Development in Young Adults Study. J Am Heart Assoc. 3: e000490. http://dx.doi.org/10.1161/JAHA.113.000490.

12. Mrizak1 I, Arfa A, Fekih M et al. 2013. Inflammation and impaired endotheliumdependant vasodilatation in non obese women with gestational diabetes mellitus: preliminary results. Lipids in Health and Disease. 12: 93.

13. Kim C. 2010. Gestational diabetes: risks, management, and treatment options. International Journal of Women's Health. 2: 339—351.

14. Xu J, Zhao YH, Chen YP et al. 2014. Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and meta)analysis. Scientific World Journal. 9: 26—932. http://dx.doi.org/10.1155/2014/926932.

15. Farias M, Puebla C, Westermeier F et al. 2010. Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C/EBPa in human umbilical vein endothelial cells from gestational diabetes. Cardiovascular Research. 86: 45—54.

16. Rajesh J, Rakesh RP, Aditya AK. 2014. Gestational diabetes: Perinatal and maternal complication in 24-28 weeks. International Journal of Medical Science and Public Health. 3(10): 1283—1288.

17. Robert SL. 2009. Gestational diabetes: causes and consequences. British Journal of Diabetes & Vascular Disease. 9: 27—31.

18. San Martin R, Sobrevia L. 2006. Gestational diabetes and the adenosine (L-arginine) nitric oxide (ALANO) pathway in human umbilical vein endothelium. Placenta. 27: 1—10.

19. Shah BR, Retnakaran R, Booth GL. 2008. Increased risk of cardiovascular disease in young women following gestational diabetes mellitus. Diabetes Care. 31: 1668—1669.

20. Pietro L, Daher S, Rudge M et al. 2010. Vascular endothelial growth factor (VEGF) and VEGF-receptor expression in placenta of hyperglycemic pregnant women. Placenta. 31: 770—780.