PERINATOLOGIYA I PEDIATRIYA.2015.3(63):84-88; doi 10.15574/PP.2015.63.84 
 

Optimization of treatment of gastrointestinal food allergy in infants 
 

Shadrin O. G., Gayduchik G. A., Kovalchuk A. A., Dyukareva S. V., Bondarenko N. Yu.

SI «Institute of Pediatrics, Obstetrics and Gynecology NAMS of Ukraine», Kyiv, Ukraine 
 

Objective: to study the clinical efficacy, safety and tolerability of a functional food product «Smektovit-D omega» and the lactase enzyme in the treatment of gastrointestinal food allergy in infants.

Patients and methods. An open prospective study of 30 children in the age from 6 months to 3 years with gastrointestinal manifestations of food allergy to cow's milk protein is conducted. Verification of the diagnosis was based on clinical and paraclinical tests, as well as the study of lactose intolerance by the way of genetic examination of polymerase chain reaction in allele 13910. The efficacy of treatment was assessed by comparison of the dynamics of the normalization of the general condition of the child and the regression of pathological symptoms of the gastrointestinal tract. Clinical examination of children and laboratory tests were conducted. After confirmed diagnosis of allergy to cow's milk protein during the breastfed babies received breast milk. Such mothers had to keep to hypoallergenic diet, eliminating «etiological» allergens of food. In case of failure or absence of breast milk children with proven allergy to cow's milk proteins were transferred to medical hydrolyzed milk formula. In case of isolated lactose intolerance were used lactose-free milk formulas with gradual transition into lactose-reduced milk formulas. In case of combination of lactose intolerance and allergy to cow's milk protein the choice of milk formula was unequivocal in favor of the medical hydrolyzed formulas. 
 

Results. Functional food product «Smektovit-D omega» had shown its efficiency and safety during the use it in the complex treatment of gastrointestinal food allergy in infants. Lactase enzyme in combination with the functional food «Smektovit-D omega» is also effective and safe in application with the complex treatment of gastrointestinal food allergy with secondary lactase deficiency. Secondary lactase deficiency is an «aggravating background» in children with gastrointestinal food allergy that does not provide a more rapid recovery and justifies the prolonged use of the enzyme lactase. 
 

Conclusions. The absence of side effects and good tolerance of functional food product «Smektovit-D omega» during the gastrointestinal food allergy, and also use of the enzyme lactase in case of signs of secondary lactase allow to recommend these preparations in infants. 
 

Key words: gastrointestinal food allergy, infants, complex therapy. 
 

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