PERINATOLOGIYA I PEDIATRIYA.2015.1(61):28–31;doi10.15574/PP.2015.61.28

The features of the state of fetoplacental complex at women with miscarriage due to the overweight and metabolic syndrome

Dyndar' E. A., Benyuk V. A.

A.A. Bogomolets National Medical University, Kyiv, Ukraine

Objective — to study the functional state of the fetoplacental complex at women with miscarriage due to the overweight and metabolic syndrome.

Patients and methods. The study involved 169 pregnant women. The study group consisted of 116 women with recurrent miscarriages, which were divided into groups according to body mass index and the presence of the metabolic syndrome. The control group consisted of 53 women who gave birth for the first time and did not have a history of extragenital pathology. In all pregnant women was determined the content of hormones and hormone proteins in the peripheral blood by the way of enzyme immunoassay with the use of the test system. Evaluation of the investigated parameters was carried out after 28 weeks of pregnancy, as for this time there were no significant differences between the control and the study group (p>0.05).

Results. In pregnant women with miscarriage due to the overweight and metabolic syndrome from the 28–32 weeks was marked a significant decrease of the E2 contents, concentrations of progesterone, placental lactogen, human chorionic gonadotropin at the simultaneous increasing of the levels of cortisol. The presence of negative changes in the regard to the content of placenta proteins from the 28–32 weeks of pregnancy in women with miscarriage due to the obesity and the metabolic syndrome is found: an increase of a-FP, PAMG, AMGF, SSBG and reducing of SP1, which is, at the same time, correlates with a high frequency of miscarriage and perinatal losses.

Conclusions. Metabolic syndrome is a significant risk factor for violations of the functional state of the placenta and fetus. This risk increases with the duration of pregnancy and update the need of improvement of the existing medical and forecasting activities.

Key words: pregnancy, miscarriage, obesity, metabolic syndrome, perinatal loss.

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