PERINATOLOGIYA I PEDIATRIYA. 2016.3(67):106-109; doi 10.15574/PP.2016.67.106 
 

Efficiency of applying of differentiated immune rehabilitation complexes in children with recurrent bronchitis at the sanatorium stage of rehabilitation

Stepanova L. S.

SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv

Objective — to study the effectiveness of differentiated immune rehabilitation complexes in children with recurrent respiratory pathology at the sanatorium stage.

Patients and methods. The studies were conducted on the basis of the local sanatorium «Ukraine» (Vorzel). The children were transferred to a sanatorium from the clinics of the State Institution «Institute of Pediatrics, Obstetrics and Gynecology NAMS Ukraine» after hospital examination and treatment at the stage of clinical remission. Over a span of 24 days of stay at sanatorium children received differentiated immune rehabilitation complexes (physiotherapy, the use of natural and preformed physical factors — physical therapy), as well as immunomodulatory therapy (synthetic immunomodulator of the peptide structure — pidotimod). With the aim of evaluation of the effectiveness of the use of differentiated immune complexes a total of 55 children with the recurrent bronchitis in the aged from 4 to 14 years were under observation. All children randomly were divided into 2 groups. The main group consisted of 36 children who received differentiated immune complexes; and the control group consisted of 19 children who received traditional rehabilitation complexes under the conditions of the sanatorium.

Results. Taking into account the nature of the influence of the differentiated immune rehabilitation complexes on the course of recurrent bronchitis of patients, for children 
with low likelihood of recurrence of the disease is recommended to apply differentiated immune rehabilitation complexes with pidotimod during the 30 days and retreatment course of pidotimod during the epidemic period (fall-winter, spring) and children with high-risk probability of recurrence need refresher course of pidotimod month before the epidemic period during the 30 days. Conclusions. Thus, the inclusion of differentiated immune rehabilitation complexes with immunomodulator pidotimod for children with recurrent bronchitis has a positive effect on the clinical course of the disease, can significantly accelerate the regression of the main clinical symptoms, improve lung function, to achieve persistent clinical and functional remission of the disease, which is caused by its influence on cellular and humoral immunity indices of nonspecific resistance and macrophage mucosa reaction of the airways.

Key words: children, recurrent bronchitis, immune rehabilitation complexes immunomodulator.

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