PERINATOLOGIYA I PEDIATRIYA. 2016.3(67):94-97 
 

Experience of the use of desloratadine sirup in the treatment of atopic dermatitis in children

Belyaeva L. M., Mikulchik N. V., Voytova E. V., Buza D. V., Bondar T. A., Zhirkevich I. I.

Belarusian Medical Academy of Post'Graduate Education, Minsk

4th Children's City Clinical Hospital, Minsk, Belarus

Published: Meditcinskie novosty. 2016. 3: 62–63.

The prevalence of atopic dermatitis among children is high due to the anatomical and physiological characteristics of a one-year-old child and the nature of the immune response of the organism. Nowadays atopic dermatitis is considered as a chronic inflammatory disease of skin, accompanied by itching and impaired gastrointestinal function. The difficulty of the treatment of atopic dermatitis is determined by polyfactorial causes and mechanisms of pathogenesis. Since the disease is chronic, treatment should be performed in incremental steps and in a continuous manner. Antihistamines, which are recognized by standard therapy and are recommended in all treatment protocols, take an important place in the treatment of atopic dermatitis among systemic effect means. The article describes the experience of clinical application of desloratadine sirup (preparation «Lordes», Nobel) in children with atopic dermatitis. High therapeutic efficacy and high drug tolerability were shown that allows to recommend it for treatment of atopic dermatitis in children.

Key words: atopic dermatitis, complex treatment, sirup «Lordes».

REFERENCES

1. Belyaeva LM. 2006. Atopicheskiy dermatit i allergicheskiy rinit u detey i podrostkov. Minsk, OOO «V.I.Z.A.GRUPP»: 8—135.

2. Belyaeva LM, Mikulchik NV. 2006. Differentsialno-diagnosticheskiy kompleks klinicheskih, immunologicheskih i gormonalnyih priznakov u detey shkolnogo vozrasta, stradayuschih atopicheskim dermatitom. Meditsinskaya panorama. 1: 16—20.

3. Zhernosek VF, Vasilevskiy IV, Novikova VI, Lyalikov SA. 2014. Klinicheskie protokolyi diagnostiki i lecheniya allergicheskih zabolevaniy u detey. Prikaz MZ RB #829 ot 08.08.2014.

4. Belyaeva LM et al. 2009. Klinicheskiy protokol diagnostiki, lecheniya i profilaktiki atopicheskogo dermatita. Uchebno-metodicheskoe posobie. Minsk: 28.

5. Revyakina VA, Filatova TA. 2009. Ot atopicheskogo dermatita do bronhialnoy astmyi u detey. Lechaschiy vrach. 11: 16—20.

6. Smirnova GI. 2013. Novoe v patogeneze i lechenii atopicheskogo dermatita u detey. Rossiyskiy pediatrich zhurn. 6: 53—57.

7. Smirnova GI. 2012. Effektivnoe lechenie atopicheskogo dermatita u detey. Rossiyskiy pediatrich zhurn. 5: 23—30.

8. Soglasitelnyiy dokument po atopicheskomu dermatitu u detey Assotsiatsii detskih allergologov i immunologov Rossii. Allergologiya i immunologiya v pediatrii. 2004. 2/3:14—110.

9. Carson CG. 2013. Risk factors for developing atopic dermatitis. Dan Med J. 60(7): 4687.

10. Flohr C, Mann J. 2014. New approaches to the prevention of childhood atopic dermatitis. Allergy. 69(1): 56—61. http://dx.doi.org/10.1111/all.12270; http://dx.doi.org/10.1111/all.12343; PMid:24372089

11. Gutowska-Owsiak D, Ogg GS. 2013. Cytokine regulation of the epidermal barrier. Clin Exp Allergy. 43(6): 586—598. PMid:23711120

12. Kabashima K. 2013. New concept of the pathogenesis of atopic dermatitis: Interplay among the barrier, allergy, and pruritus as a trinity. J Dermatol Sci. S0923—1811 (13) 00055—8. http://dx.doi.org/10.1016/j.jdermsci.2013.02.001

13. Kim KH. 2013. Overview of atopic dermatitis. Asia Pac Allergy. 3(2): 79—87. http://dx.doi.org/10.5415/apallergy.2013.3.2.79; PMid:23667830 PMCid:PMC3643056

14. Scheinmann P, Pham TN, Karila C. 2012. Allergic march in children, from rhinitis to asthma: management, indication of immunotherapy. Arch Pediatr. 19(3): 330—334. http://dx.doi.org/10.1016/j.arcped.2012.01.003; PMid:22306361

15. Spergel JM. 2010. Epidemiology of atopic dermatitis and atopic march in children. Immunol Allergy Clin North Am. 30(3): 269—280. http://dx.doi.org/10.1016/j.iac.2010.06.003; PMid:20670812

16. Takeuchi YL, Christen-Zaech S. 2013. Atopic dermatitis in children: general principles of management. Rev Med Suisse. 9(380): 712—717. PMid:23621040

17. Tan AU, Gonzalez ME. 2012. Management of severe atopic dermatitis in children. J Drugs Dermatol. 11(10): 1158—1165. PMid:23134980

18. Beikert FC, Langenbruch AK, Radtke MA et al. 2014. Willingness to pay and quality of life in patients with atopic dermatitis. Arch Dermatol Res. 306(3): 279—286. http://dx.doi.org/10.1007/s00403-013-1402-1; PMid:23982630