Modern Pediatrics. Ukraine. (2025).7(151): 14-21. doi: 10.15574/SP.2025.7(151).1421
Malinovska T. M., Bolshova O. V., Kvachenyuk D. A., Sprinchuk N. A., Lukashuk I. V.
SI «V.P. Komisarenko Institute of Endocrinоlogy and Metabolism of the NAMS of Ukraine», Kyiv

For citation: Malinovska TM, Bolshova OV, Kvachenyuk DA, Sprinchuk NA, Lukashuk IV. (2025). Vitamin D status, leptin, and lipid profile in adolescents with hypothalamic dysfunction. Modern Pediatrics. Ukraine. 7(151): 14-21. doi: 10.15574/SP.2025.7(151).1421.
Article received: Jul 03, 2025. Accepted for publication: Nov 09, 2025.

Aim – to investigate the vitamin D status, lipid profile and leptin levels in a cohort of adolescents with hypothalamic dysfunction (DH) for early identification of possible risk factors for cardiovascular and metabolic disorders
Materials and methods. 246 adolescents (including 133 boys) aged 10-17 years with DH accompanied by excess body weight (BW)/obesity were examined. Body mass index, levels of total cholesterol (TC), triglycerides (ТG), high (HDL-C) and low density lipoprotein cholesterol, leptin, atherogenic index (IA), and blood 25-hydroxyvitamin D (25(OH)D) were determined.
Results. Excess BW was found in 82 (31.0%) patients, obesity of the I degree – in 84 (32.0%) children, II degree – in 51 (19.0%) children, III degree – in 29 (11.0%) children. The indicators of 25(OH)D in the blood corresponded to the deficiency of vitamin D. The increase in the degree of obesity was accompanied by a significant increase in the leptin level and a decrease in the 25(OH)D level. The increase in the deficiency of vitamin D was associated with significantly increased levels of TС and IA and a decrease in the HDL-C level. The most significant changes in lipid fractions were observed in patients with DH and III degree of obesity, who had the lowest content of 25(OH)D in the blood.
Conclusions. The present study found the certain significant changes in some lipid fractions, namely TC, IA and HDL-C in adolescents with hypothalamic dysfunction associated with excess BW/obesity and vitamin D deficiency, which is a high risk factor for cardiovascular and metabolic disorders and requires early intervention and the introduction of preventive measures.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution mentioned in the paper. Informed consent was obtained from the children's guardians for the study.
The authors declare no conflict of interest.
Keywords: vitamin D, lipid profile, leptin, hypothalamic dysfunction, obesity, risk factors for cardiovascular and metabolic disorders, adolescents.

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