Modern Pediatrics. Ukraine. (2025).5(149): 7-13. doi: 10.15574/SP.2025.5(149).713
Koloskova O. K.¹, Kosakovskyi A. L.², Marusyk U. I.¹, Kosakivska I. A.², Herchyk V. I.³, Hrushetska N. P.^4
1Bukovina State Medical University, Chernivtsi, Ukraine
²Shupyk National University of Healthcare of Ukraine, Kyiv
³OKNP "Chernivtsi Regional Children's Clinical Hospital", Ukraine
⁴National Specialized Children's Hospital "OHMATDYT", Kyiv, Ukraine

For citation: Koloskova OK, Kosakovskyi AL, Marusyk UI, Kosakivska IA, Herchyk VI, Hrushetska NP. (2025). A expedient choice in the treatment of acute upper respiratory tract infections in childhood. Modern Pediatrics. Ukraine. 5(149): 7-13. doi: 10.15574/SP.2025.5(149).713.
Article received: Jun 28, 2025. Accepted for publication: Sep 10, 2025.

Acute tonsillopharyngitis is one of the main reasons for prescribing antibiotics to children. Inappropriate use of antibiotics in children often leads to the development of antibioticresistance.
Aim – to investigate the effectiveness and safety of the use "Coldysept nanoSilver throat spray" compared to standard therapy to optimize the treatment of acute tonsillopharyngitis in children.
Materials and methods. 80 patients aged 6 to 17 years with signs of acute respiratory infection of the upper respiratory tract were observed and divided into two groups. The main group consisted of 50 patients who received standard therapy with "Coldysept nanoSilver throat spray" for 7 days, the comparison group consisted of 30 patients who received standard therapy according to guidelines.
Results. The effectiveness of the "Coldysept nanoSilver throat spray" use in the therapy of children on the 3rd day was associated with a significantly better reduction of sore throat, difficulty swallowing and plaque on the tonsils. The frequency registration of the minimum score of acute process symptoms severity on the 5th day treatment demonstrates a similar prevalence of them in main group. On the 7th day of therapy, these symptoms were not observed in patients in the main group, while in children in the control group the symptoms persisted.
Conclusions. The obtained data of the dynamic comparative analysis of the use of “Coldisept nanoSilver throat spray” in the complex treatment of children with acute upper respiratory tract infections compared to standard tactics confirm that the proposed approach significantly accelerates recovery with good tolerability and safety of use.
The research was carried out in accordance with the principles of the Declaration of Helsinki. Informed consent of the child and child's parents was obtained for the researches.
No conflict of interest was declared by the author.
Keywords: acute tonsillopharyngitis, children, treatment, Coldisept nanoSilver throat spray.

REFERENCES

1. Ather B, Mirza TM, Edemekong PF. (2023). Airborne Precautions. Mar 13. In: Stat Pearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; 2025 Jan.

2. Barbieri E, Donà D, Cantarutti A, Lundin R, Scamarcia A, Corrao G et al. (2019). Antibiotic prescriptions in acute otitis media and pharyngitis in Italian pediatric out patients. Ital J Pediatr. 45(1):103. https://doi.org/10.1186/s13052-019-0696-9; PMid:31420054 PMCid:PMC6697973

3. Ebell MH, Smith MA, Barry HC, Ives K, Carey M. (2000). The rational clinical examination. Does this patient have strep throat? JAMA. 13; 284(22): 2912-2918. https://doi.org/10.1001/jama.284.22.2912; PMid:11147989

4. ESCMID Sore Throat Guideline Group; Pelucchi C, Grigoryan L, Galeone C, Esposito S, Huovinen P et al. (2012). Guideline for the management of acute sore throat. ClinMicrobiolInfect. Suppl 1: 1-28. https://doi.org/10.1111/j.1469-0691.2012.03766.x; PMid:22432746

5. Kosakovskyi AL, Holovnya OM, Gunko SG, Kosakivska IA, Sinyachenko VV. (2024). Determination of the antimicrobial action of «Coldisept nanoSilver nasal spray» and «Coldisept nanoSilver throat spray». Modern Pediatrics. Ukraine. 5(141): 11-15. https://doi.org/10.15574/SP.2024.5(141).1115

6. Liang K, Liu Y, Jiang F. (2024). Analysis of therapeutic effect of silver-based dres sings on chronic wound healing. IntWound J. 21(8): e70006. https://doi.org/10.1111/iwj.70006; PMid:39087750 PMCid:PMC11292664

7. Mathur P, Jha S, Ramteke S, Jain NK. (2018). Pharmaceutical aspects of silver nano particles. Artif Cells Nanomed Biotechnol. 46; Suppl 1: 115-126. https://doi.org/10.1080/21691401.2017.1414825; PMid:29231755

8. MOZ Ukrainy. (2022). Metodychni rekomendatsii shchodo znebolennia postrazhdalykh na etapakh evakuatsii. Nakaz Ministerstva okhorony zdoroviaUkrainy 28 chervnia 2022 roku No. 1122.

9. Palm J, Fuchs K, Stammer H, Schumacher-Stimpfl A, Milde J. (2018) Efficacy and safety of a triple active sore thro at lozenge in the treatment of patients with аcute pharyngitis: Results of a multi-centre, randomised, placebo-controlled, double-blind, parallel-grouptrial (DoriPha). Int J ClinPract. 72(12): e13272. https://doi.org/10.1111/ijcp.13272; PMid:30329199 PMCid:PMC6282512

10. Pankhurst CL. (2013). Candidiasis (oropharyngeal). BMJ ClinEvid. 8; 2013: 1304.

11. Pellegrino R, Timitilli E, Verga MC, Guarino A, Iacono ID, Scotese I et al. (2023). Other members of the Italian Panel for the Management of Acute Pharyngitis in Children. Acute pharyngitis in children and adults: descriptive comparison of current recommendations from national and international guidelines and future perspectives. Eur J Pediatr. 182(12): 5259-5273. https://doi.org/10.1007/s00431-023-05211-w; PMid:37819417 PMCid:PMC10746578

12. Pugach P, Sadeghi-Latefi N. (2024). Supporting respiratory epithelia and lowering inflammation to effectively treat common cold symptoms: A randomized controlled trial. PLoSOne. 27; 19(11): e0301959. https://doi.org/10.1371/journal.pone.0301959; PMid:39602479 PMCid:PMC11602100

13. Shulman ST, Bisno AL, Clegg HW, Gerber MA, Kaplan EL, Lee G et al. (2012) Infectious Diseases Society of America. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. Nov 15; 55(10): e86-102. https://doi.org/10.1093/cid/cis629; PMid:22965026 PMCid:PMC7108032

14. Sykes EA, Wu V, Beyea MM, Simpson MTW, Beyea JA. (2020). Pharyngitis: Approach to diagnosis and treatment. Can Fam Physician. 66(4): 251-257.

15. Thai TN, Dale AP, Ebell MH. (2018). Signs and symptoms of Group A versus Non-Group A strep throat: A meta-analysis. Fam Pract. 23; 35(3): 231-238. https://doi.org/10.1093/fampra/cmx072; PMid:29045629

16. Vishwanath N, Whitaker C, Allu S, Clippert D, Jouffroy E, Hong J et al. (2022). Silver as an Antibiotic-Independent Antimicrobial: Review of Current Formulations and Clinical Relevance. SurgInfect (Larchmt). 23(9): 769-780. https://doi.org/10.1089/sur.2022.229; PMid:36178480

17. Wächtler H, Kaduszkiewicz H, Kuhnert O, Malottki KA, Maaß S, Hedderich J et al. (2023). Influence of a guideline or an additional rapid strep test on antibiotic prescriptions for sore throat: the cluster randomized controlled trial of HALS (Halsund Antibiotika Leitlinien Strategien). BMC PrimCare. 20; 24(1): 75. https://doi.org/10.1186/s12875-023-01987-w; PMid:36941540 PMCid:PMC10029262

18. Yoon YK, Park CS, Kim JW, Hwang K, Lee SY, Kim TH et al. (2017). Guidelines for the Antibiotic Use in Adults with Acute Upper Respiratory Tract Infections. Infect Chemother. 49(4): 326-352. https://doi.org/10.3947/ic.2017.49.4.326; PMid:29299900 PMCid:PMC5754344