Ukrainian Journal of Perinatology and Pediatrics. 2023. 4(96): 77-80; doi: 10.15574/PP.2023.96.77
Podolskyi Vl. V., Bugro V. V., Donskoy B. V.
SI “Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine”, Kyiv

For citation: Podolskyi VlV, Bugro VV, Donskoy BV. (2023). Influence of smoking on immune response and susceptibility of women to sexually transmitted infections. Ukrainian Journal of Perinatology and Pediatrics. 4(96): 77-80; doi: 10.15574/PP.2023.96.77.
Article received: Aug 07, 2023. Accepted for publication: Dec 15, 2023.

The study highlights the importance of understanding the impact of cigarette smoking on the immune system, especially in women. It sets the context for the study by discussing the increasing concern about how lifestyle factors like smoking can affect susceptibility to infections, particularly STIs.
Purpose – to explore how cigarette smoking affects the immune response in women and to investigate whether smoking increases the risk of contracting STIs. It seeks to identify specific immunological changes caused by smoking that could explain increased susceptibility to infections.
Materials and methods. The methodology involves a comprehensive analysis of saliva samples from 160 women. This group includes both smokers and non-smokers, with some having chronic inflammatory diseases due to STIs. The study measures levels of immunoglobulins and lysozyme-peptide in the saliva to assess changes in the immune response.
The results demonstrate significant alterations in immunoglobulin levels and lysozyme-peptide in the saliva of women who smoke, especially those with chronic inflammatory diseases caused by STIs. These findings indicate that smoking can modify local immunity and exacerbate the immune response to inflammatory processes associated with STIs.
Conclusions. The study concludes that cigarette smoking has a critical impact on women's reproductive health by altering their immune response and increasing their susceptibility to STIs. It underscores the need for greater attention to smoking as a major public health issue, emphasizing its role in women's health and the importance of incorporating smoking cessation strategies in disease prevention programs.
The study protocol was approved by the Local ethics committees of the institutions mentioned in the paper. An informed parental consent was obtained for the study in women.
No conflict of interests was declared by the authors.
Keywords: cigarette smoking, women’s health, immune response, sexually transmitted infections, immunoglobulins, mucosal immunity, saliva composition, chronic inflammatory diseases, reproductive health, public health.

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