- Ureteral obstruction after endoscopic treatment of the vesicoureteral reflux in children
Ureteral obstruction after endoscopic treatment of the vesicoureteral reflux in children
Paediatric Surgery (Ukraine).2023.3(80):78-82; doi: 10.15574/PS.2023.80.78
Peterburgskyy V. F., Kalishchuk O. A., Klius A. L.
SI «Academician O.F. Vozianov Institute of Urology of the NAMS of Ukraine», Kyiv
For citation: Peterburgskyy VF, Kalishchuk OA, Klius AL. (2023). Ureteral obstruction after endoscopic treatment of the vesicoureteral reflux in children. Paediatric Surgery (Ukraine). 3(80): 78-82; doi: 10.15574/PS.2023.80.78.
Article received: Jun 23, 2023. Accepted for publication: Sep 10, 2023.
Purpose – to investigate the ureteral obstruction (UO) frequency after endoscopic injection of the vesicoureteral reflux (VUR) in children.
Materials and methods. 1068 children aged 8 months -15 years were respectively reviewed after endoscopic treatment of the VUR grades 2-4. The following factors were analyzed in terms of ureteral obstruction: age, sex, reflux grade. Also the clinical manifestations were reviewed as the ureteral obstruction management types (conservative – 28 (52.8%), stenting – (26.5%), reimplantation of the ureter – 11 (20.7%) as well.
Statistical analysis of the frequency of OS (categorical data) was performed using nonparametric estimation methods (χ², Fisher's exact test). A difference of p<0.05 was considered statistically significant.
Results. The total incidence of ureteral obstruction was 3.44% (53/1539 ureters). There were early (41 children) and late (12 children) obstructed units. The following risk factors for developing ureteral obstruction proved to be significant: sex (males), low reflux grade. The early UO was treated mostly with watchful waiting, stenting (13 cases) and 2 cases were submitted to open surgery. In late UO ureteral reimplantation was utilized (9 cases) as well as ureteral stenting was helpful.
Conclusions. UO is an infrequent but essential complication of the endoscopic VUR correction. The early UO cases are effectively treated by watchful waiting with/without empty bladder or ureteral stenting. Ureteral reimplantation seems to be the main procedure in late UO cases.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the authors.
Keywords: vesicoureteral reflux, ureteral obstruction, risk factors, children.
REFERENCES
1. Alizadeh F, Mazdak H, Khorrami MH, Khalighinejad P, Shoureshi P. (2013, Aug). Postoperative ureteral obstruction after endoscopic treatment of vesicoureteral reflux with polyacrylate polyalcohol copolymer (Vantris®). Journal of Pediatric Urology. 9; 4: 488-492. https://doi.org/10.1016/j.jpurol.2012.11.007; PMid:23219423
2. Chertin B, Mele E, Kocherov S, Zilber S, Gerocarni Nappo S, Capozza N. (2018). What are the predictive factors leading to ureteral obstruction following endoscopic correction of VUR in the pediatric population? J Pediatr Urol. 8: 510-517.
3. Chung JM, Park ChS, Lee SD. (2015, Jul). Postoperative ureteral obstruction after endoscopic treatment for vesicoureteral reflux. Korean J Urol. 56 (7): 533-539. https://doi.org/10.4111/kju.2015.56.7.533; PMid:26175873 PMCid:PMC4500811
4. Escolino M, Kalfa N, Castagnetti M, Caione P et al. (2023). Endoscopic injection of bulking agents in pediatric vesicoureteral reflux: a narrative review of the literature. J Pediatric Surgery International. 39: 133. https://doi.org/10.1007/s00383-023-05426-w; PMid:36806763 PMCid:PMC9938816
5. Friedmacher F, Puri P. (2019). Ureteral obstruction after endoscopic treatment of vesicoureteral reflux: does the type of injected bulking agent matter? Curr Urol Rep. 20 (9): 49. https://doi.org/10.1007/s11934-019-0913-5; PMid:31289951
6. Garcia-Aparicio L, Rodo J, Palazon P, Martin O, Blazquez-Gomez E, Manzanares A et al. (2013). Acute and delayed vesicoureteral obstruction after endoscopic treatment of primary vesicoureteral reflux with dextranomer/hyaluronic acid copolymer: why and how to manage. J Pediatr Urol. 9: 493-497. https://doi.org/10.1016/j.jpurol.2013.02.007; PMid:23507288
7. Mazzone L, Gobet R, Gonzalez R, Zweifel N, Weber DM. (2012). Ureteral obstruction following injection of dextranomer/hyaluronic acid copolymer: an infrequent but relevant complication. J Pediatr Urol. 8: 514-519. https://doi.org/10.1016/j.jpurol.2011.10.002; PMid:22023846
8. Nakonechnyy RA, Prytula VP, Nakonechnyy AI. (2017). Complication of intravesical correction of vesicoureteral reflux in children. Paediatric surgery. Ukraine. 4 (57): 72-79. https://doi.org/10.15574/PS.2017.57.72
9. Papagiannopoulos D, Rosoklija I, Cheng E, Yerkes E. (2017). Delayed obstruction with asymptomatic loss of renal function after dextranomer/hyaluronic acid copolymer (Deflux) injection for vesicoureteral reflux: a close look at a disturbing outcome. Urology. 101: 63-66. https://doi.org/10.1016/j.urology.2016.09.013; PMid:27687330
10. Rubenwolf PC, Ebert AK, Ruemmele P, Rösch WH. (2013). Delayed-onset ureteral obstruction after endoscopic dextrano-mer/hyaluronic acid copolymer (Deflux) injection for treat-ment of vesicoureteral reflux in children: a case series. Urology. 81 (3): 659-662. https://doi.org/10.1016/j.urology.2012.11.044; PMid:23452811
11. Serdar T. (2015, May 5). Guidelines on paediatric urology. European Association of Urology. European Society for Paediatric Urology. URL: http://uroweb.org/wp-content/uploads/EAU-Guidelines-Paediatric-Urology-2015.pdf.
12. Serrano Durba A, Bonillo García MA, Moragues Estornell F, Domínguez Hinarejos C, Sanguesa C, Martínez Verduch M, García Ibarra F. (2006, Feb). Vesicoureteric reflux endoscopic treatment complications in childhood. Actas Urol Esp. 30 (2): 170-174. Spanish. https://doi.org/10.1016/S0210-4806(06)73419-2; PMid:16700207
13. Snodgrass WT. (2004). Obstruction of a dysmorphic ureter following dextranomer/hyaluronic acid copolymer. J Urol. 171: 395-396. https://doi.org/10.1097/01.ju.0000101995.85004.95; PMid:14665941
14. Yankovic F, Swartz R, Cuckow P, Hiorns M, Marks SD, Cherian A et al. (2013). Incidence of Deflux® calcification masquerading as distal ureteric calculi on ultrasound. J Pediatr Urol. 9; 6pt A: 820-824. https://doi.org/10.1016/j.jpurol.2012.10.025; PMid:23186595