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  • Syndrome of muscle weakness and myalgia in pediatric practice on clinical examples
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Syndrome of muscle weakness and myalgia in pediatric practice on clinical examples

Ukrainian Journal of Perinatology and Pediatrics. 2022. 1(89): 35-44; doi 10.15574/PP.2022.89.35
Oshlyanska O. A.1,2, Artsymovych  A. G.1,2, Nadtochiy T. G.2
1Shupyk National Healthcare University of Ukraine, Kyiv
2SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine», Kyiv

For citation: Oshlyanska OA, Artsymovych AG, Nadtochiy TG. (2022). Syndrome of muscle weakness and myalgia in pediatric practice on clinical examples. Ukrainian Journal of Perinatology and Pediatrics. 1(89): 35-44; doi 10.15574/PP.2022.89.35.
Article received: Dec 12, 2021. Accepted for publication: Mar 13, 2022.

The article presents data on the main causes of muscle weakness in children and discusses the clinical features of diseases that may be accompanied by muscle weakness. Emphasis is placed on the possibilities of differential diagnosis of muscle weakness syndrome in children through the use of various methods of examination. The algorithm of differential diagnostic search at muscular weakness is offered. The possibility of its application in pediatric practice is demonstrated on clinical examples. Despite certain common features in the onset of the disease in the presented cases, a detailed examination makes it possible to distinguish between congenital and acquired causes of muscle damage and refer the patient for appropriate treatment.
It should be noted that muscle weakness is a fairly common symptom in a child. More often it is not associated with damage to the muscles themselves. The causes of chronic weakness differ significantly in children of all ages. In a child with clinical signs of muscle weakness, it is necessary to conduct a thorough examination, aimed primarily at excluding various serious diseases.
The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the authors.
Key words: children, muscle weakness, differential diagnosis.

REFERENCES

1. Antypkin YuH, Okhotnikova OM, Oshlianska OA, Omelchenko LI. (2019). Problemni pytannia dytiachoi revmatolohii. Kyiv: Lohos: 700.

2. Ballabio A, Gieselmann V. (2009). Biochimica et Lysosomal disorders: From storage to cellular damage Biophysica Acta. 1793: 684-696. https://doi.org/10.1016/j.bbamcr.2008.12.001; PMid:19111581

3. Cassandrini D, Trovato R, Rubegni A et al. (2017). Congenital myopathies: clinical phenotypes and new diagnostic tools Italian Journal of Pediatrics. 43: 101. https://doi.org/10.1186/s13052-017-0419-z; PMid:29141652 PMCid:PMC5688763

4. Chinnery PF. (2000). Primary Mitochondrial Disorders Overview. In: Adam MP, Ardinger HH, Pagon RA et al, editors. GeneReviews. Seattle (WA): University of Washington, Seattle, 1993-2022.

5. ESE. (2022). Clinical Practice Guidelines. The European Society of Endocrinology. The voice for endocrinology. URL: https://www.ese-hormones.org/publications/guidelines/.

6. Fardeau M, Tome F. (1994). Vrozhdennыe myopatyy. V: Engler AG, Franzini-Armstrong C, redaktorы. Myolohyia. Niu-York: Makhrou-Khyll: 1487-1533.

7. Goddard AF, James MW, McIntyre AS, Scott BB. (2011). Guidelines for the management of iron deficiency anaemia. 60: 1309e1316. https://doi.org/10.1136/gut.2010.228874; PMid:21561874

8. Gonorazky HD, Bönnemann CG, Dowling JJ. (2018). Henetycheskaia osnova y fenotypycheskye osobennosty vrozhdennыkh myastenycheskykh syndromov Handbook of Clinical Neurology. 148: 549-564. https://doi.org/10.1016/B978-0-444-64076-5.00036-3; PMid:29478600

9. Gorman GS, Chinnery PF, DiMauro S et al. (2016). Mitochondrial diseases. Nature Reviews Disease Primers. 2: 16080. https://doi.org/10.1038/nrdp.2016.80; PMid:27775730

10. Jasndeep Kaler, Azhar Hussain, Sundip Patel, Shankar Majhi. (2020, Feb). Neuromuscular Junction Disorders and Floppy Infant Syndrome: A Comprehensive Review. Cureus. 12 (2): e6922. https://doi.org/10.7759/cureus.6922

11. Kompendium. (2022). Neyrotsirkulyatornaya distoniya. URL: https://compendium.com.ua/clinical-guidelines/cardiology/section-12/glava-1-nejrotsirkulyatornaya-distoniya.

12. MSD. (2022). The Trusted Provider of Medical Information since 1899. MSD Manuals Global Medical Knowledge. URL: https://www.msdmanuals.com.

13. Olshansky A. (2007). Virtual Mentor American Medical Association Journal of Ethics August. Clinical Pearl Diagnosis and Treatment of Guillain-Barre Syndrome. 9 (8): 552-554. https://doi.org/10.1001/virtualmentor.2007.9.8.cprl1-0708; PMid:23218149

14. Oshlianska OA, Shevchenko NS, Biliavska YuV. (2021). Yuvenilnyi dermatomiozyt. Pro shcho varto pamiataty doroslomu revmatolohu? Ukrainskyi revmatolohichnyi zhurnal. 4: 86.