- Rare clinical case: granular cell tumor of the esophagus (Aprikosov tumor) in a teenager
Rare clinical case: granular cell tumor of the esophagus (Aprikosov tumor) in a teenager
Paediatric surgery.Ukraine.2021.4(73):77-83; doi 10.15574/PS.2021.73.77
Marakhouski Kirill 1, Zapalianski Andrei 1, Ovseichik Denis 1, Nikalayeva Katsiaryna 1, Pataleta Aleh 1, Nestsiaruk Liubou 1, Kudlasevich Hanna 2
1Republican scientific and practical center of pediatric surgery, Minsk, Republic of Belarus
2City Clinical Pathoanatomical Bureau, Minsk, Republic of Belarus
For citation: Marakhouski K, Zapalianski A, Ovseichik D, Nikalayeva K et al. (2021). Rare clinical case: granular cell tumor of the esophagus (Aprikosov tumor) in a teenager. Paediatric Surgery.Ukraine. 4(73):77-83; doi 10.15574/PS.2021.73.77.
Article received: Aug 22, 2021. Accepted for publication: Dec 08, 2021.
Granular cell tumors were first described by Weber in 1854. But its muscular origin was suggested, studied in detail and differentiated by the pathologist A.I. Abrikosov in 1926. With the development of immunohistochemical analysis, a version of Abrikosov's tumor pathogenesis appeared, suggesting its origin from Schwann cells. The data obtained confirmed the presence of protein S-100, neuron-specific enolase (NSE) and CD68 in tumor cells. At present, when carrying out histochemical analysis, the expression of proteins S-100 and CD68 in tumor cells is a diagnostic criterion for Abrikosov's tumor. In treatment of granular cell tumors of the esophagus, preference is given to minimally invasive endoscopic techniques, since conservative therapy has proved to be ineffective. Considering that in most cases the tumor is benign in nature, recently many authors have recommended endoscopic resection of the mucous membrane and dissection in the submucosa.
This article presents the experience of treating a child with a rare Abrikosov's tumor in the lower third of the esophagus using endoscopic technique.
The clinical case described proved to be a difficult diagnostic task, since Abrikosov's tumor in the esophagus in a teenager is an extremely rare pathology with a rare localization. To remove the tumor, a non-standard endoscopic technique was chosen, which made it possible to remove the formation in a single block, that is, radically, since preoperative morphological verification was impossible.
Much attention is focused on the importance of endoscopic examination in diagnostic screening and the choice of treatment tactics. This work demonstrates high efficiency and safety of endoscopic tumor removal in this localization. The use of this surgical treatment technique made it possible to radically remove the tumor and ensure a smooth course of the postoperative period.
The research was carried out in accordance with the principles of the Helsinki declaration. The informed consent of the patient was obtained for conducting the studies.
No conflict of interest was declared by the authors.
Key words: granular cell tumor, Abrikosov's tumor, tumor of the esophagus, esophagus, children, endoscopic treatment.
REFERENCES
1. Abrikossoff A. (1926). Uber Myome. Virchows Arch path Anat. 260: 215-233. https://doi.org/10.1007/BF02078314
2. Abrikossoff AI. (1931). Weitere Untersuchungen uber Myoblastenmyome. Virchows Arch. path Anat. 280: 723-740. https://doi.org/10.1007/BF02038883
3. An S, Jang J, Min K et al. (2015). Granular cell tumor of the gastrointestinal tract: histologic and immunohistochemical analysis of 98 cases. Hum Pathol. 46 (6): 813-819. https://doi.org/10.1016/j.humpath.2015.02.005; PMid:25882927
4. Apracio SR, Lumsden CE. (1969). Light and electron microscopic studies on granular cell myoblastoma of tongue. J Pathol. 97 (2): 339-355. https://doi.org/10.1002/path.1710970221; PMid:4311005
5. Buratti S, Savides TJ, Newbury RO, Dohil R. (2004, Jan 1). Granular Cell Tumor of the Esophagus: Report of a Pediatric Case and Literature Review. Journal of Pediatric Gastroenterology and Nut r i t i on. 38 (1): 97-101. https://doi.org/10.1097/00005176-200401000-00021; PMid:14676603
6. Chen WS, Zheng XL, Jin L, Pan XJ, Ye MF. (2014). Novel diagnosis and treatment of esophageal granular cell tumor: report of 14 cases and review of the literature. Ann Thorac Surg. 97: 296-302. https://doi.org/10.1016/j.athoracsur.2013.08.042; PMid:24140217
7. Chursin AA, Bylina EA, Logvinova TV, Drachev VV, Starodubcev EG, Mizernickij YuL. (2012). Opuhol' Abrikosova: disseminirovannoe porazhenie legkih u rebenka 4 let. Pediatriya. Prilozhenie k zhurnalu Consilium medicum. 1: 77-80.
8. Cui Y, Tong SS, Zhang YH, Li HT. (2018). Granular cell tumor: A report of three cases and review lf literature. Cancer Biomarkers. 23 (2): 173-178. https://doi.org/10.3233/CBM-170556; PMid:30223384
9. Dzieniecka M, Komorowska A, Grzelak-Krzymianowska A, Kulig A. (2011). Multiple congenital epuli (congenital granular cell tumours) in the newborn: a case report and review of literature. Pol J Pathol. 62 (1): 69-71. PMID: 21574109.
10. Gasanov AM, Hristoforova EA, Danielyan ShN, Tarabrin EA, Rabadanov KM. (2020). Endoskopicheskoe lechenie zernistokletochnoj opuholi pishchevoda (klinicheskij sluchaj). Dokazatel'naya gastroenterologiya. 9 (3): 67-72. https://doi.org/10.17116/dokgastro2020903167
11. Goetz A, Nweze N, Joshi A, Farma J. (2018, Feb 27). Case Reports Ann R Coll Surg Engl. 100 (4): e85-e87. Epub Synchronous subcutaneous granular cell tumours, a rare presentation Affiliations expand. https://doi.org/10.1308/rcsann.2018.0016; PMid:29484942 PMCid:PMC5958858
12. Guo-Qiang Xu, Hong-Tan Chen, Cheng-Fu Xu, Xiao-Dong Teng. (2012, Dec 21). Esophageal granular cell tumors: report of 9 cases and a literature review.World J Gastroenterol. 18 (47): 7118-7121. https://doi.org/10.3748/wjg.v18.i47.7118; PMid:23323018 PMCid:PMC3531704
13. Hong JB, Choi CW, Kim HW, Kang DH, Park SB, Kim SJ, Kim DJ. (2015). Endoscopic resection using band ligation for esophageal SMT in less than 10 mm. World J Gastroenterol. 21 (10): 2982-2987. https://doi.org/10.3748/wjg.v21.i10.2982; PMid:25780296 PMCid:PMC4356918
14. Iwamuro M, Tanaka T, Kanzaki H, Kawano S, Kawahata Y, Okada H. (2018). Esophageal Granular Cell Tumors Can Be Differentiated from Leiomyomas Using Endoscopic Ultraspnography. Intern Med. 57 (11): 1509-1515. https://doi.org/10.2169/internalmedicine.9816-17; PMid:29321437 PMCid:PMC6028673
15. Jian Wang, Xiong-Zeng Zhu, Ren-Yuan Zhang. (2004, Dec). Malignant granular cell tumor: a clinicopathologic analysis of 10 cases with review of literature. Review Zhonghua Bing Li, Xue Za Zhi. 33 (6): 497-502. PMID: 15634442.
16. Johnston J, Helwig EB. (1981). Granular cell tumors of the gastrointestinal tract and perianal region: a study of 74 cases. Dig Dis Sci. 26: 807-816. https://doi.org/10.1007/BF01309613; PMid:6169495
17. Johnston J, Helwig EB. (1981). Granular cell tumors of the gastrointestinal tract and perianal region: a study of 74 cases. Dig Dis Sci. 26: 807-816. https://doi.org/10.1007/BF01309613; PMid:6169495
18. Kanno A, Satoh K, Hirota M, Hamada S, Umino J, Itoh H, Masamune A, Egawa S, Motoi F, Unno M, Ishida K, Shimosegawa T. (2010). Granular cell tumor of the pancreas: A case report and review of literature. World J Gastrointest Oncol. 2 (2): 121-124. https://doi.org/10.4251/wjgo.v2.i2.121; PMid:21160931 PMCid:PMC2999167
19. Keishi Komori, Kazuya Akahoshi, Yoshimasa Tanaka, Yasuaki Motomura, Masaru Kubokawa, Soichi Itaba, Terumasa Hisano, Takashi Osoegawa, Naotaka Nakama, Risa Iwao, Masafumi Oya, Kazuhiko Nakamura. (2012, Jan 16). Endoscopic submucosal dissection for esophageal granular cell tumor using the clutch cutter. World J Gastrointest Endosc. 4 (1):17-21. https://doi.org/10.4253/wjge.v4.i1.17; PMid:22267979 PMCid:PMC3262174
20. Le BH, Boyer PJ, Lewis JE, Kapadia SB. (2004). Granular cell tumor: immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and ki-67 proliferative index with clinical correlation. Arch Pathol Lab Med. 128 (7): 771-775. https://doi.org/10.5858/2004-128-771-GCTIAO; PMid:15214825
21. Le Gullou Y, Nogues C, Bourdilloud P. (1974, Jul-Aug). Abrikosov's tumor in the newborn. Rev Stomatol Chir Maxillofac. 75 (5): 801-808. PMID: 4376259.
22. Lee JS, Ko KO, Lim JW et al. (2016). Granular cell tumor of the esophagus in an adolescent. Korean J Pediatr. 59 (1): S88. https://doi.org/10.3345/kjp.2016.59.11.S88; PMid:28018455 PMCid:PMC5177722
23. Mahoney A, Garg A, Wolpowitz D, Mahalingam M. (2010). Atypical granular cell tumor-apropos of a case with indeterminate malignant potential. Am J Dermatopathol. 32 (4): 370-373. https://doi.org/10.1097/DAD.0b013e3181be99e3; PMid:20514678
24. Manevska B, Klisarov D. (1979, Jan-Feb). A case of congenital myoblastic myoma (Abrikosov's tumor). Stomatologiia (Sofiia). 61 (1): 62-64. PMID: 233536.
25. Mtvralashvili DA, Vasil'evyh TA, Majnovskaya OA, Likutov AA, Veselov VV, Vaganov YuE. (2021). Klinicheskij sluchaj udaleniya opuholi Abrikosova slepoj kishki metodom dissekcii v podslizistom sloe. Ambulatornaya hirurgiya. 18 (1): 144-149. https://doi.org/10.21518/1995-1477-2021-18-1-144-149
26. Porta N, Mazzitelli R, Cacciotti J et al. (2015). A case report of a rare intramuscular granular cell tumor. Diagn Pathol. 10: 162. https://doi.org/10.1186/s13000-015-0390-1; PMid:26377191 PMCid:PMC4573292
27. Rose B, Tamvakopoulos GS, Yeung E, Pollock R, Skinner J, Briggs T et al. (2009). Granular cell tumours: a rare entity in the musculoskeletal system. Sarcoma: 765927. https://doi.org/10.1155/2009/765927; PMid:20169099 PMCid:PMC2821775
28. Seo IS, Azzarelli B, Warner TF, Goheen MP, Senteney GE. (1984). Multiple visceral and cutaneous granular cell tumors. Ultrastructural and immunocytochemical evidence of Schwann cell origin. Cancer. 53: 2104-2110. https://doi.org/10.1002/1097-0142(19840515)53:10<2104::AID-CNCR2820531019>3.0.CO;2-F
29. Simsek H, Ozaslan E, Sokmensuer C, Tatar G. (2002). Multifocal granular cell tumor of the esophagus: a case report. Turk J Cancer. 32: 116-122.
30. Tsai SJ, Lin CC, Chang CW et al. (2015). Benign esophageal lesions: endoscopic and pathologic features. World J Gastroenterol. 21: 1091. https://doi.org/10.3748/wjg.v21.i4.1091; PMid:25632181 PMCid:PMC4306152
31. Weber CO. (1854). Anatomische Untersuchung einer hypertrophischen Zunge nebst Bemerkungen uber die Neubildung quergestreifter Muskelfasern. Virchows Arch A Pathol Anat. 7: 115-125. https://doi.org/10.1007/BF01936232
32. Xu GQ, Chen HT, Xu CF, Teng XD. (2012). Esophageal granular cell tumors: Report of 9 cases and a literature review. World J Gastroenterol. 18 (47): 7118-7121. https://doi.org/10.3748/wjg.v18.i47.7118; PMid:23323018 PMCid:PMC3531704
