1

MEDICAL PUBLICATION
CONFERENCES AND SEMINARS
MARKETING RESEARCH

  • Modern diagnostic and treatment approaches of congenital cytomegalovirus infection: a clinical case
en To content Full text of article

Modern diagnostic and treatment approaches of congenital cytomegalovirus infection: a clinical case

Ukrainian Journal of Perinatology and Pediatrics. 2020. 4(84): 48-54; doi 10.15574/PP.2020.84.48
Shadrin O. H.1, Volokha A. P.2, Chumachenko N. H.1, Fysun V. M.1, Zaiets V. V.1
1SI «Institute of Pediatrics Obstetrics and Gynecology named after academical O.M. Lukyanova of the NAMS of Ukraine», Kyiv
2Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine

For citation: Shadrin H, Volokha AP, Chumachenko NH, Fysun VM, Zaiets VV. (2020). Modern diagnostic and treatment approaches of congenital cytomegalovirus infection: a clinical case. Ukrainian Journal of Perinatology and Pediatrics. 4(84): 48–54. doi 10.15574/PP.2020.84.48
Article received: Jul 27, 2020. Accepted for publication: Dec 07, 2020.

Cytomegalovirus infection (CMV) is one of the most common causes of fetal infection. Recently fetal infections cause from 11% to 45% of perinatal losses, according to various authors, and are considered to be one of the most likely causes of congenital malformations, which lead to infants disability and reduce quality of life. CMV-infection clinical picture is very diverse, disguised as other diseases. There may be clinical manifestations of both generalized infection and single organ damage, because the virus has tropism to various organs and tissues. Timely diagnosis and treatment are the key to successful therapy of even severe manifestations of congenital CMV-infection in infants. Antiviral drugs usage can be sufficiently justified in patients with severe infection and can prevent complications.
A clinical case of a manifest form of cytomegalovirus infection with severe hepatitis in an infant is presented and the therapeutic efficacy and safety of the ganciclovir and valganciclovir antiviral drugs are shown. The study is performed in accordance with principles of the Declaration of Helsinki. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the article. Informed consent of parents was obtained for the research. The authors declare no conflict of interest.
Key words: infants, congenital cytomegalovirus infection, ganciclovir, valganciclovir, clinical case.

REFERENСES

1. Belyaeva IA, Bombardirova EP, Potehina TV, Gurskaya AS. (2018). Tsitomegalovirusnaya infektsiya u detey pervyih mesyatsev zhizni: variantyi techeniya, sovremennyie podhodyi k terapii (klinicheskie sluchai). Pediatricheskaya farmakologiya. 15: 2. https://doi.org/10.15690/pf.v15i2.1873

2. Blazquez-Gamero D, Galindo Izquierdo A, Del Rosal T et al. (2017). Prevention and treatment of fetal cytomegalovirus infection with cytomegalovirus hyperimmune globulin: a multicenter study in Madrid. J Matern Fetal Neonatal Med: 1-9. https://doi.org/10.1080/14767058.2017.1387890; PMid:28978246

3. Capretti MG, Marsico C, Guidelli Guidi S et al. (2017). Neonatal and long-term ophthalmological findings in infants with symptomatic and asymptomatic congenital cytomegalovirus infection. J Clin Virol. 97: 59-63. https://doi.org/10.1016/j.jcv.2017.11.001; PMid:29149633

4. Chernyshova LI, Volokha AP, Bondarenko AV ta in. (2016). Infektsiini khvoroby u ditei. Pidruchnyk. Za red Chernyshovoi LI. Kyiv: VSV «Medytsyna». 2: 1016-6. ISBN: 978-617-505-458-1.

5. Gantt S, Dionne F, Kozak FK et al. (2016). Cost-effectiveness of Universal and Targeted Newborn Screening for Congenital Cytomegalovirus Infection. JAMA Pediatr. 170 (12): 1173-1180. https://doi.org/10.1001/jamapediatrics.2016.2016; PMid:27723885

6. Petrova GV, Shahgildyan VI, Chistozvonova EA i dr. (2016). Opyit primeneniya protivovirusnoy terapii vrozhdennoy generalizovannoy tsitomegalovirusnoy infektsii. Detskie infektsii. 2: 61-68.

7. Rawlinson W et al. (2017). Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis. 17: e177-188. https://doi.org/10.1016/S1473-3099(17)30143-3

8. Scherbina NA, Vyigovskaya LA. (2017). Etiologicheskaya struktura vnutriutrobnyih infektsiy u beremennyih i novorozhdennyih s oslozhnennyim techeniem rannego neonatalnogo perioda. Scientific Journal ScienceRise: Medical Science. 10 (18): 48–54.

9. Vasilev VV, Volodin NN, Gorlanov IA, Gorshkov DA i dr. (2018). Klinicheskie rekomendatsii [proekt] po diagnostike, lecheniyu i profilaktike vrozhdennoi tsitomegalovirusnoi infektsii. URL: http://www.raspm.ru/files/CMVI.pdf.

10. Yulish EI. (2015). Tsitomegalovirusnaya infektsiya u detey: podhodyi k lecheniyu pri razlichnom techenii infektsionnogo protsessa. Zdorove rebenka. 4 (64): 11–18.