- Screening coagulation tests in normal pregnancy
Screening coagulation tests in normal pregnancy
HEALTH OF WOMAN. 2020.4(150): 58–60; doi 10.15574/HW.2020.150.58
Zhuk S. I. 1, Us I. V. 2
1Shupyk National Medical Academy of Postgraduate Education, Kiev
2Perinatal center, Kiev
The objective: to evaluate the performance of screening coagulation tests in normal pregnancy.
Materials and methods. A study of screening coagulation tests was conducted with the participation of 124 patients with normal pregnancy in terms of 12–14, 20–22, 28–30 and 37–40 weeks of gestation. The control group consisted of 82 patients who were at the pregravid stage of pregnancy planning. Coagulation tests were determined on a HELENA 2000 coagulometer. Namely, the activated partial thromboplastin time, the percentage of prothrombin by Quick and fibrinogen were examined.
Results. During normal pregnancy, a dynamic, statistically significant increase in plasma fibrinogen level was determined. This indicator during full-term pregnancy differed from that of non-pregnant women by 1.8 times. During all normal pregnancies, there was no statistically significant dynamics of the activated partial thromboplastin time and the percentage of prothrombin by Quick, but there was a tendency towards these indicators increase in coagulation potential with an increase in the gestation term.
Conclusion. When assessing a screening coagulation tests, pregnancy term should be taken into account first of all, rather than comparing the obtained values with reference indices for non-pregnant women.
Keywords: screening coagulation tests, hemostatic system, fibrinogen level, prothrombin percentage by Quick, activated partial thromboplastin time.
REFERENCES
1. Dubei L. 2017. Dopovid: «Systema zghortannia krovi v klinichnii praktytsi: suchasna taktyka diahnostyky, likuvannia ta monitorynhu». Praktychnyi lektorii «Nevidkladni stany v praktytsi akushera-ginekoloha». Zhinochyi likar 3:20–25.
2. Zhuk SI, Us IV, Atamanchuk IM. 2012. Trombofilii ta nevynoshuvannia vahitnosti: suchasne bachennia problemy. Zdorovia Ukrainy 4(8):28.
3. Momot AP, Kudinova IYu, Belozerov DE. 2016. Fiziologicheskaya beremennost – model nesostoyavshegosya tromboza. Tromboz, gemostaz i reologiya 67:297–298.
4. Strizhakov AN, Timohina EV, Ignatko IV, Belotserkovtseva LD. 2015. Patofiziologiya ploda i platsenty. Moskva, GEOTAR-Media:176.
5. Hannah Cohen, Patrick O'Brien. 2015. Disoders of thrombosis and hemostasis in pregnancy: а guide to management. Second Еdition. London:435. https://doi.org/10.1007/978-3-319-15120-5
6. Pal B Szecsi, Maja Jørgensen, Anna Klajnbard, Malene R Andersen, Nina P Colov, Steen Stender. 2010. Haemostatic reference intervals in pregnancy. Thromb Haemost. 103:718-727. https://doi.org/10.1160/TH09-10-0704; PMid:20174768
7. Royal College of Obstetricians and Cynecologists. Reducing the risk of Thrombosis and Embolism during Pregnancy and Puerperium. Green-Top Guideline № 37в. London: Royal College of Obstetricians and Gynecologists. 2015.
8. Sue Pavord, Beverley Hunt. 2018. The obstetric hematology manual: а guide to management. Second Edition. Cambridge: 345. https://doi.org/10.1017/9781316410837