Ukrainian Journal of Perinatology and Pediatrics. 2020. 2(82):42-46; doi 10.15574/PP.2020.82.42
Davydova Iu. V., Limanskaya A. Yu., Neroznak Yu. P.
SI «Institute of Pediatrics, Obstetrics and Gynecology named after Academician O.M. Lukyanova NAMS of Ukraine», Kyiv

For citation: Davydova IuV, Limanskaya AYu, Neroznak YuP. (2020). Correction of iron deficiency and iron deficiency anemia in women following a vegetarian and vegan diet. Ukrainian Journal of Perinatology and Pediatrics. 2(82): 42-46. doi 10.15574/PP.2020.82.42
Article received: Feb 12, 2020. Accepted for publication: May 30, 2020.

The aim. To investigate the presence of iron deficiency and iron deficiency anemia in women who adhere to a vegan diet and the effectiveness of antianemic therapy with Sorbifer Durules.
Materials and methods. 32 women of reproductive age who followed a vegetarian and vegan diet were examined preconceptively. Blood counts in general blood tests and ferritine were studied before and after treatment with Sorbifer Durules. Women received the oral iron preparation Sorbifer Durules, 1 tablet twice a day (4 mg/kg/day). Monitoring the effectiveness of treatment was assessed by the rate of reticulocytes, the concentration of hemoglobin and ferritin on 8-th day, 3–4 weeks and 12 weeks after antianemic treatment. Among all the women studied, 24 (75%) became pregnant and were also examined in the first trimester for iron deficiency and anemia.
Results and conclusions. In women who have certain dietary restrictions (vegetarians and vegan women), were observed iron deficiency (low concentrations of ferritin). Important is the fact that hemoglobin and iron metabolism are significantly lower in the group of women who are vegans compared to vegetarians, which is due to the peculiarities of nutrition with a more limited intake of iron from food. The effectiveness of antianemic therapy with this drug has been proven by the occurrence of recyculocytosis, which is observed 7–8 days after the start of treatment. The normalization of the iron depot occurs 3 months after the start of therapy, which proves the need for long-term therapy with Sorbifer. It is important that among women who became pregnant after pregravidarum consultation and correction of anemia, in the first trimester of pregnancy, hemoglobin and ferritin values were within the reference values. The study proves the need for the administration of oral iron medications (according to the WHO recommendation in an intermittent mode) in order to reduce the risk of anemia and increase hemoglobin concentrations in women at risk (vegetarians and vegans.)
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies.
No conflict of interest were declared by the authors.
Key words: pregnancy, vegan diet, vegetarians, iron deficiency anemia, iron deficiency.

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