HEALTH OF WOMAN. 2016.5(111):117–119 
 

Activity of natural killer cells in the eutopic endometrium AT adenomyosis in women with different implantation characteristics

Nosenko O. M., Moskalenko T. Ya., Kosyuga O. M.

Odessa national medical University

РІ «City clinical hospital №1», city of Odessa

The objective: of the study was a comparative study of the number and distribution of NK-cells in eutopic endometrium at adenomyosis in women with different implantation characteristics.

Patients and methods. A comparative analysis of 32 endometrial samples from non-pregnant women of reproductive age with adenomyosis and a history of miscarriage, 30 non-pregnant women with adenomyosis who desired pregnancy ended in childbirth, and there were no episodes of spontaneous abortion, and 10 conditionally gynecologically healthy non-pregnant women without adenomyosis, who desired pregnancy ended in childbirth. It was investigated endometrium content of NK-cells using liquid murine monoclonal antibodies to the antigens CD16 + and CD56 + by immunohistochemistry.

Results. It was found that infiltration of eutopic endometrial by NK-cells in women with adenomyosis exceeds that of conventionally healthy fertile persons. At adenomyosis the number of CD56+NK-cells in eutopic endometrium in women with implantation failure exceeds that in patients with implantation competence in 6.8 times (p<0,01), CD16+NK-cells – in 7.1 times (p<0,01).

Conclusion. Determination of NK-cells in eutopic endometrium of women with adenomyosis can be used at the stage of the pre-gravid preparation for the forecast of implantation success and carry out the necessary immune correction.

Key words: adenomyosis, eutopic endometrium, immunohistochemistry, natural killer cells, implantation failure.

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