HEALTH OF WOMAN. 2019.4(140): 92–95; doi 10.15574/HW.2019.140.92

Sumtsov D. G., Kusyomenska M. L., Sumtsov G. A.
Medical Institute of Sumy State University

In the literature review the authors present an analysis of the current stateproblem of ovarian cancer and ways of its possible solution. According to clinicalobservations and conducted in recent decades by morphological,immunohistochemical and molecular genetic studies it is fairly proved that theprimary cause of serous ovarian cancer is the pathology of the mucous layer offallopian tube. In the fallopian tube as a result of ciculation of inflammation andcarcinogens elements arises dysplasia of the mucosa with the development of thepreinvasive and initial invasive carcinoma with subsequent damage of the ovariesand pelvic peritoneum. Retrospective studies of a significant number of women’shealth status who had a deligation or removal of fallopian tubes in previous years showed a decrease in the disease incidence of serous ovarian cancer from 30 to 90%. The conclusions about the possibility of preventive measures of ovariancancer by opportunistic salpingectomy at post-productive age are made. In many world countries (Canada, China, France, Italy, Austria) the introduction of such a method of prevention has been started. We believe that in Ukraine there is an urgent need and all possibilities to solve this problem.
Key words: ovarian cancer, preventive measures, opportunistic salpingectomy.

REFERENCES

Absaturova AV, Yezhova LS, Faisullina NM et al. 2016. Morphological and immunohistochemical characteristics of changes in the mucous membrane of the fallopian tube during epithelial ovarian tumors. Arch. Pathol. 2: 3-9. https://doi.org/10.17116/patol20167823-9; PMid:27070769

Bulletin of the National Cancer Registry Ukraine 19. Cancer in Ukraine, 2016-2017 edited by OO Kolesnik . National Cancer Institute. K:130. 2017.

Zhordania KI, Payanidi UG, Kalinicheva EV. 2014. New paradigm of ovarian cancer etiology Russian Biotherapeutic Journal 13(2): 95-102.

Sumtsov GA, Sumtsov DG. 2015. Primary cancer of the fallopian tubes: monograph.Sumy: Sumy State University:229.

Chen Y, Du H, Bao L, Liu W. (2018 Jan) Opportunistic salpingectomy at benign gynecological surgery for reducing ovarian cancer risk: a 10-year single centre experience from China and a literature review. J Cancer. 1;9(1):141-147. https://doi.org/10.7150/jca.21187; PMid:29290779 PMCid:PMC5743721

Chene G1, de Rochambeau B2, Le Bail-Carval K et al. 2016, Jul-Aug. Current surgical practice of prophylactic and opportunistic salpingectomy in France. Gynecol Obstet Fertil. 44(7-8):377-84. https://doi.org/10.1016/j.gyobfe.2016.05.003; PMid:27363615

Cibula D, Widschwendter M, Majek O, Dusek L. 2011. Tubal ligation and the risk of ovarian cancer:review and meta-analysis.Hum Reprod Update 17(1):55–67. https://doi.org/10.1093/humupd/dmq030; PMid:20634209

James R. Conner, Emily Meserve Ellen Pizer, Judy Garber et al. .2014, Feb. Outcome of unexpected adnexal neoplasia discovered during risk reduction salpingo-oophorectomy in women with germ-line BRCA1 or BRCA2 mutationsGynecol Oncol. 132(2): 280–286.  https://doi.org/10.1016/j.ygyno.2013.12.009; PMid:24333842 PMCid:PMC3932113

Cress RD, Chen YS, Morris CR, Petersen M & Leiserowitz GS. 2015. Characteristics of long-term survivors of epithelial ovarian cancer. Obstet. Gynecol. 126:491–497. https://doi.org/10.1097/AOG.0000000000000981; PMid:26244529 PMCid:PMC4545401

Crum CP, Drapkin R, Kindelberger D, Medeiros F, Miron A, Lee Y. 2007. Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer. Clin Med Res. 5:35–44. (PMC free article) (PubMed). https://doi.org/10.3121/cmr.2007.702; PMid:17456833 PMCid:PMC1855333

Erickson BK, Conner MG, Landen CN Jr. 2013. The role of the fallopian tube in the origin of ovarian cancer. Am J Obstet Gynecol. 209 (5):409-14. https://doi.org/10.1016/j.ajog.2013.04.019; PMid:23583217 PMCid:PMC3937451

Findley AD, Siedhoff MT, Hobbs KA, Steege JF, Carey ET, McCall CA et al. 2013. Short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve: a pilot randomized controlled trial. Fertil Steril. 100:1704–1708. https://doi.org/10.1016/j.fertnstert.2013.07.1997; PMid:23993887 PMCid:PMC3844119

Kezia Gaitskell, Kate Coffey, Jane Green, Kirstin Pirie et al. 2016, Apr 26. Tubal ligation and incidence of 26 site-specific cancers in the Million Women Study.Br J Cancer. 114(9): 1033–1037. https://doi.org/10.1038/bjc.2016.80; PMid:27115569 PMCid:PMC4984917

Garcia C, Martin M, Tucker LY, Lyon L, Armstrong MA, McBride-Allen S et al. 2016. Experience with opportunistic salpingectomy in a large, community-based health system in the United States. Obstet Gynecol. 128:277–283. https://doi.org/10.1097/AOG.0000000000001531; PMid:27399999

Sophia HL, George Ruslan Garcia and Brian M. Slomovitz. 2016. Ovarian Cancer: The Fallopian Tube as the Site of Origin and Opportunities for Prevention.Front Oncol. 6:108. https://doi.org/10.3389/fonc.2016.00108; PMid:27200296 PMCid:PMC4852190

Havrilesky LJ, Moorman PG, Lowery WJ, Gierisch JM et al. 2013, Jul. Oral contraceptive pills as primary prevention for ovarian cancer: a systematic review and meta-analysis. Obstet Gynecol. 122(1):139-47. https://doi.org/10.1097/AOG.0b013e318291c235; PMid:23743450

Kindelberger DW1, Lee Y, Miron A, Hirsch MS, Feltmate C et al. 2007, Feb. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship. Am J Surg Pathol. 31(2):161-9. https://doi.org/10.1097/01.pas.0000213335.40358.47; PMid:17255760

Kurman RJ1, Shih IeM. 2011, Jul. Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer–shifting the paradigm. Hum Pathol. 42(7):918-31. https://doi.org/10.1016/j.humpath.2011.03.003; PMid:21683865 PMCid:PMC3148026

Kurman RJ, Shih IeM. 2016, Apr. The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and ExpandedAm J Pathol. 186(4):733-47. https://doi.org/10.1016/j.ajpath.2015.11.011; PMid:27012190 PMCid:PMC5808151

Kwon JS, Tinker A, Pansegrau G, McAlpine J et al. 2013, Jan. Prophylactic salpingectomy and delayed oophorectomy as an alternative for BRCA mutation carriers. Obstet Gynecol. 121(1):14-24. https://doi.org/10.1097/AOG.0b013e3182783c2f; PMid:23232752

Intidhar Labidi-Galy S, Eniko Papp, […]Victor E. Velculescu. 2017. High grade serous ovarian carcinomas originate in the fallopian tube Nature 8;1093. https://doi.org/10.1038/s41467-017-00962-1; PMid:29061967 PMCid:PMC5653668

Lee Y, Miron A, Drapkin R, Nucci MR et al. 2007, Jan. A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol. 211(1):26-35. https://doi.org/10.1002/path.2091; PMid:17117391

Madsen C, Baandrup L, Dehlendorff C, Kjaer SK. 2015, Jan. Tubal ligation and salpingectomy and the risk of epithelial ovarian cancer and borderline ovarian tumors: a nationwide case-control study. Acta Obstet Gynecol Scand. 94(1):86-94. https://doi.org/10.1111/aogs.12516; PMid:25256594

McAlpine JN, Hanley GE, Woo MM, Tone AA et al. 2014, May. Opportunistic salpingectomy: uptake, risks, and complications of a regional initiative for ovarian cancer prevention. Am J Obstet Gynecol. 210(5):471.e1-11. https://doi.org/10.1016/j.ajog.2014.01.003; PMid:24412119

Medeiros F1, Muto MG, Lee Y, Elvin JA et al. 2006, Feb. The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome. Am J Surg Pathol. 30(2):230-6. https://doi.org/10.1097/01.pas.0000180854.28831.77; PMid:16434898

Mittal N, Srinivasan R, Gupta N, Rajwanshi A et al. 2016, Oct-Dec. Secretory cell outgrowths, p53 signatures, and serous tubal intraepithelial carcinoma in the fallopian tubes of patients with sporadic pelvic serous carcinoma. Indian J Pathol Microbiol. 59(4):481-488. https://doi.org/10.4103/0377-4929.191789; PMid:27721278

Mohamed AA, Yosef AH, James C, Al-Hussaini TK et al. 2017, Jul. Ovarian reserve after salpingectomy: a systematic review and meta-analysis. Acta Obstet Gynecol Scand. 96(7):795-803. https://doi.org/10.1111/aogs.13133; PMid:28471535

Narod SA, Sun P, Ghadirian P, Lynch H, Isaacs C, Garber J et al. 2001. Tubal ligation and risk of ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study. Lancet 357(9267):1467–70. (PubMed) (Cross Ref). https://doi.org/10.1016/S0140-6736(00)04642-0

Nezhat FR. 2015. New insights in the pathophysiology of ovarian cancer and implications for screening and prevention. Am J Obstet Gynecol 213(3):262-7. https://doi.org/10.1016/j.ajog.2015.03.044; PMid:25818671

Piek JM, Verheijen RH, Kenemans P, Massuger LF et al. 2003, Aug. BRCA1/2-related ovarian cancers are of tubal origin: a hypothesis. Gynecol Oncol. 90(2):491. https://doi.org/10.1016/S0090-8258(03)00365-2

Piek JM. et al. 2001. Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer. J. Pathol. 195:451–456. https://doi.org/10.1002/path.1000; PMid:11745677

Potz FL, Tomasch G, Polterauer S, Laky R, Marth C, Tamussino K. 2016. Incidental (prophylactic) salpingectomy at benign gynecologic surgery and cesarean section: a survey of practice in Austria. Geburtshilfe Frauenheilkd. 76:1325–1329. https://doi.org/10.1055/s-0042-116493; PMid:28017973 PMCid:PMC5177549

Przybycin CG1, Kurman RJ, Ronnett BM et al. 2010, Oct. Are all pelvic (nonuterine) serous carcinomas of tubal origin? Am J Surg Pathol. 34(10):1407-16. https://doi.org/10.1097/PAS.0b013e3181ef7b16; PMid:20861711

Przybycin CG1, Kurman RJ, Ronnett BM et al. 2010, Oct. Are all pelvic (nonuterine) serous carcinomas of tubal origin? Am J Surg Pathol. 34(10):1407-16. https://doi.org/10.1097/PAS.0b013e3181ef7b16; PMid:20861711

Rice MS1, Murphy MA, Tworoger SS. 2012, May. Tubal ligation, hysterectomy and ovarian cancer: A meta-analysis. J Ovarian Res. 15;5(1):13. https://doi.org/10.1186/1757-2215-5-13; PMid:22587442 PMCid:PMC3386864

Salvador S, Gilks B, Köbel M, Huntsman D, Rosen B, Miller D. 2009. The fallopian tube: primary site of most pelvic high-grade serous carcinomas. Int J Gynecol Cancer. 19(1):58-64. https://doi.org/10.1111/IGC.0b013e318199009c; PMid:19258943

Siegel RL, Miller KD, Jemal A. 2015, Jan-Feb. Cancer statistics, 2015. CA Cancer J Clin. 65(1):5-29. https://doi.org/10.3322/caac.21254; PMid:25559415

Sieh W, Salvador S, McGuire V, Weber RP et al. 2013, Apr. Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies. Int J Epidemiol. 42(2):579-89.

Soegaard M, Jensen A, Høgdall E, Christensen L et al. 2007, Jun. Different risk factor profiles for mucinous and nonmucinous ovarian cancer: results from the Danish MALOVA study. Cancer Epidemiol Biomarkers Prev. 16(6):1160-6. https://doi.org/10.1158/1055-9965.EPI-07-0089; PMid:17548679

Karl Tamussino. 2017, Jul. Should national societies recommend opportunistic salpingectomy? J Gynecol Oncol 28(4): e53. https://doi.org/10.3802/jgo.2017.28.e53; PMid:28541640 PMCid:PMC5447151

Tone AA, Salvador S, Finlayson SJ, Tinker AV et al. 2012, May. The role of the fallopian tube in ovarian cancer. Clin Adv Hematol Oncol. 10(5):296-306.

Lindsey A. Torre, Carol E. DeSantis, Kimberly D. Miller, Ahmedin Jemal et al. 2018. Ovarian cancer statistics, 2018. CA Cancer J Clin. 68:284–296. https://doi.org/10.3322/caac.21456; PMid:29809280 PMCid:PMC6621554

Venturella R, Rocca M, Lico D, Trapasso S et al. 2016. Prophylactic bilateral salpingectomy for the prevention of ovarian cancers: what is happening in Italy? Eur J Cancer Prev 25:410–415. https://doi.org/10.1097/CEJ.0000000000000191; PMid:26275007

Venturella R, Morelli M, Lico D, Di Cello A et al. 2015, Nov. Wide excision of soft tissues adjacent to the ovary and fallopian tube does not impair the ovarian reserve in women undergoing prophylactic bilateral salpingectomy: results from a randomized, controlled trial. Fertil Steril. 104(5):1332-9. https://doi.org/10.1016/j.fertnstert.2015.08.004; PMid:26335129

Zweemer RP, van Diest PJ, Verheijen RH, Ryan A, Gille JJ et al. 2000. Molecular evidence linking primary cancer of the fallopian tube to BRCA1 germline mutations.Gynecol Oncol. 76(1):45-50. https://doi.org/10.1006/gyno.1999.5623; PMid:10620440