HEALTH OF WOMAN. 2019.4(140): 41–42; doi 10.15574/HW.2019.140.41

Tkachenko Zh. S.
Shupyk National Medical Academy of Postgraduate Education, Kiev

The objective: depression of frequency of not incubation at women from groups of high risk on a basis studying at them level 25OHD3, and also clinical-functional, immunologic and microbiological features, and also development and deployment of advanced algorithm of diagnostic and treatment-and-prophylactic actions.
Materials and methods. After the accounting of all criteria of including and switching off included in the main group 60 patients with risk of not incubation of pregnancy (discontinuing threat), the group of control was made by 30 women with physiological pregnancy. The complex of the conducted researches included clinical, laboratory, tool and statistical methods.
Results. Use of the algorithm improved by us allows to warn pregnancy not incubation at women of group of high risk, and also to reduce the frequency of premature births (by 3,3%) and perinatal pathology (for 6,7%). At women with accompanying pathology of gastrointestinal tract and inflammatory processes of genesial system it is necessary to define level 25OHD3 at a pregravidale stage and during pregnancy.
Conclusion. Use of advanced algorithm allows to reduce the frequency of genesial losses at women of group of high risk.
Key words: genesial losses, diagnostics, prophylaxis, vitamin D.

REFERENCES

Dergacheva IA. 2014. Osobennosti immunopatogeneza gerpesvirusnyih infektsiy vo vremya beremennosti. Vestnik RGMU 4:18–21.

Dobrohotova YuE. 2015. Kaltsitriol u zhenschin s urogenitalnoy infektsiey i nevyinashivaniem beremennosti. Lechenie i profilaktika 4 (16): 43–46.

Savchenko TN. 2016. Obespechennost beremennyih vitaminom D v pervoy polovine gestatsii. Materialyi Vserossiyskogo kongressa s mezhdunarodnyim uchastiem «Ambulatorno-poliklinicheskaya praktika: diagnostika, lechenie, profilaktika». M: 123–124.

Scheplyagina LA. 2016. Vitamin D kak marker immunnogo statusa zhenschin s nevyinashivaniem beremennosti infektsionnogo geneza. Vserossiyskiy mezhdistsiplinarnyiy meditsinskiy zhurnal TERRA MEDICA. 1–2 (83–84): 43–46.

Bodnar LM. 2017. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J. Nutr. 139:1157–61. https://doi.org/10.3945/jn.108.103168; PMid:19357214 PMCid:PMC2682987

Cannell J. 2016. Use of vitamin D in clinical practice. Alternftive medicine review 13;1:6–20.

Merewood A. 2018. Association between vitamin D deficiency and primary cesarean section. The Journal of Clinical Endocrinology and Metabolism 94: 940–945. https://doi.org/10.1210/jc.2008-1217; PMid:19106272 PMCid:PMC2681281