HEALTH OF WOMAN. 2019.3(139): 53–59; doi 10.15574/HW.2019.139.53

Strelko G. V.
Medical Center «AviMed», Kyiv

The objective: search for an optimal protocol for ovarian stimulation in women with a reduced ovarian response with investigation of its effectiveness by studying the number of oocytes obtained, embryo quality, as well as pregnancy and implantation rate.

Materials and methods. The study of the effectiveness of the controlled ovarian stimulation regimen in poor responders women using long acting FSH in the protocol with GnRH antagonists compared with the modified protocol combining the use of aromatase inhibitors (letrozole) and gonadotropins was conducted.

Results. The stimulation of the ovaries with Coriophiolotropin alfa and the aromatase inhibitor has been shown to be effective in the treatment of patients with a poor response to stimulation. Patient perceptions of corifolotropin-alpha protocols show better tolerability than traditional protocols due to fewer injections, which reduces the likelihood of early termination of treatment. Modified protocols with the use of aromatase inhibitors should be used in cases of optimization of financial expenses during the CSR protocol with a similar result.

Conclusion. The results of the study prove the effectiveness of the stimulation regimens used in controlled ovarian stimulation for poor responders. The use of coriophyllotropin alfa and aromatase inhibitor letrozole in combination with additional FSH doses and gonadotropin-rilising hormone antagonists simplifies the design of the stimulation regimen, minimizes the number of injections with shorter stimulation and optimizes patient financial costs.

Key words: controlled ovarian stimulation, poor responders, coriophyllotropin alpha, aromatase inhibitors.

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