PAEDIATRIC SURGERY.UKRAINE.2019.2(63):41-49; DOI 10.15574/PS.2019.63.41

Dzhuma Kristina, Prytula Vasyl, Dubrovin Alexander, Godik Oleg
Bogomolets National Medical University, Kyiv, Ukraine

Objective. The paper is focused on the features and grade of changes in the immune system under the extrahepatic portal hypertension and after splenorenal and mesocaval shunting operations.

Materials and methods. In the study were included 100 children, in whom the cell, humoral and unspecific parts of immune system were evaluated. The leading pathological factors were defined.

Results. It was established that there is significant tensity in the humoral part (IgМ, IgA) and phagocytosis, secondary cell immune deficiency with decreasing of general number of lymphocytes and subpopulations of lymphocytes (СD3+, СD4+, СD8+). Immunological parameters after splenorenal shunting were statisticily significant approached to the age norms (p<0,05) comparing to those after mesocaval shunting. However, the operative treatment essentially doesn’t improve the condition of the immune system.

Conclusion. The parameters of immunogramme should be considered while monitoring such category of patients, selection of the immunocorrective and detoxication therapy for prevention of postoperative complications and for the further management under extrahepatic portal hypertension.

Key words: portal hypertension, immune status, mesocaval shunt, splenorenal shunt, children.

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Article received: Jan 30, 2019. Accepted for publication: Jun 13, 2019.