HEALTH OF WOMAN. 2016.10(116):107–109; doi 10.15574/HW.2016.116.107 
 

Perinatal consequences in women with the Polycystic Ovarу Syndrome on a background insuline resistance in anamnesis

Onusyko O. V.

SHEI «Uzhgorod national University», Uzhgorod city maternity hospital

In this article features of perinatal consequences in women, pregnancy, which became after the treatment of the Polycystic Ovarу Syndrome on a background of insuline resistance are considered. The clinical and static retrospective analysis of 102 of childbirth histories in women with the Polycystic Ovarу Syndrome in anamnesis is conducted for period from 2009th to 2012th on the base of maternity hospital in Uzhorod. It was found that insuline resistance has negative influence on the state of new-born.

The objective: to study the effect of insulin resistance in pregnant women on neonatal status.

Patients and methods. Retrospective clinico-statistical analysis of 100 individual cards and stories of labor in patients with polycystic ovary syndrome on the background of insulin resistance and 100 stories of newborns. And the first study group were children of women with PCOS on the background of IR. This is the primary group. And II group (control) took the children of healthy women, whose number was 115. Pregnant women, who were executed in vitro fertilization, the study has not been included.

Resalts. The influence of insulin resistance in pregnant women on neonatal status. Established negative its effects on infants, namely an increase in the incidence of perinatal complications.

Conclusion. The state of hyperandrogenism and insulin resistance in women with PCOS in history, of course, adversely affects the condition of the newborn: increased risk of asphyxia of the newborn, hypoxic-ischemic encephalopathy, respiratory insufficiency I, II and III degrees, reduced muscle tone. Also increased risk of hypoxic cardiopathy, cardio-respiratory depression and the courts.

Key words: pregnancy, polycystic ovary syndrome, insulin resistance, newborn.

REFERENCES

1. Kachalina TS. 2004. Giperandrogeniya i nevyinashivanie beremennosti. Rossiyskiy vestnik akushera-ginekologa 3:5–10.

2. Saveleva GM, Kurtser MA, Shalina RI. 2002. Rol intranatalnoy ohranyi ploda i uluchshenie perinatalnyih ishodov. M:3–8.

3. Tovstanovska VO, Us IV. 2006. Giperinsulinizm v akusherstvi ta ginekologiyi i yogo terapiya. Nova meditsina. 2006. 2:21–23.

4. Adams J et al. 2005. Policystic Ovary Syndrom and insulin resistance. British Medical Journal. 293:355–59. https://doi.org/10.1136/bmj.293.6543.355

5. Almahbobi J et al. 2003. Polysystic ovary syndrome. Clinical Endocrinology. 44:571–580. https://doi.org/10.1046/j.1365-2265.1996.724545.x

6. Melmed S, Casanueva FF et al. 2011. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. Endocrine Society. J Clin Endocrinol Metab. 96:273–288. https://doi.org/10.1210/jc.2010-1692; PMid:21296991

7. Speiser PW, Azziz R, Baskin LS et al. 2010. Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline. Endocrine Society. J Clin Endocrinol Metab. 95:4133–4160. https://doi.org/10.1210/jc.2009-2631; PMid:20823466 PMCid:PMC2936060

8. Vermeulen А, Ando S. 1978. Prolactin and adrenal androgen secretion. Clin Endocrinol (Oxf). 8:295–303. https://doi.org/10.1111/j.1365-2265.1978.tb02772.x

9. Glasow А, Breidert M, Haidan A, Anderegg U, Kelly PA, Bornstein SR. 1996. Functional aspects of the effect of prolactin (РRL) оn adrenal steroidogenesis and distribution of the PRL receptor in the human adrenal gland. J Clin Endocrinol Metab. 81:3103–3111. https://doi.org/10.1210/jc.81.8.3103; https://doi.org/10.1210/jcem.81.8.8768882; PMid:8768882