SOVREMENNAYA PEDIATRIYA.2018.1(89):116-123; doi 10.15574/SP.2018.89.116

Stepanovskyy Y. S., Chernyshova L. I., Hilfanova A. M., Volokha A. P., Bondarenko A. V., Sulimanova O. S., Lapiy F. I., Kasyan O. I., Habrys H. M., Lytvynovska K. S.
Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
Kyiv City Children's Clinical Hospital No.1, Ukraine

The broadest observation of Kawasaki disease (KD) in children in Ukraine is presented that included 23 clinical cases in Kyiv. The frequency of complete KD was 56% and incomplete one was 44%. The coronary vessel affection rate was 33% and the highest one was revealed in infants — 83%. The symptoms and laboratory manifestations of KD are analyzed. The characteristics of the incomplete KD diagnosis are presented. The prevalence of KD in Kyiv in 2016 is calculated to be 4.6 per 100,000 children under 5 years of age and the expected prevalence of KD in Ukraine in 2016 — 103 cases.
Key words: Kawasaki disease, children, coronaritis, coronary vessel aneurysms, fever, intravenous human normal immunoglobulin.

Reference

1. Banadyha NV. (2014). Case of Kawasaki syndrome. Sovremennaya pediatriya. 4: 40–42.

2. Berezhnyi VV, Sovtus KhM, Bondarets YuI. (2017). Kawasaki's disease in children. Features of diagnosis and treatment (lecture). Sovremennaya pedyatriya. 3: 38–44.

3. Bondarenko AV, Chernyshova LI, Holovatiuk IV et al. (2013). Features of clinical course and diagnostics of incomplete syndrome Kawasaki. Sovremennaya pedyatriya. 4: 165–168.

4. Haiduk TA, Shostakovych-Koretska LR. (2009). Clinical case of Kawasaki disease in a 7-month infant. Medychni perspektyvy. 14(4): 24–28.

5. Dorofeeva H.D. (1982). Case of Kawasaki disease (mucosal-skin-lymphatic syndrome) in a boy of 6 years. Pedyatr. 4: 65–66.

6. Zerbino DD, Kuryliak OB, Boiko OI, Hoshovska II. (2014). Kawasaki disease: 4-years old boy with coronary aneurisms. Praktychna anhiolohiia. 3(66): 9–12.

7. Kuryliak OB. (2010). Kawasaki disease in children (cases). Pediatrics, obstetrics and gynecology. 1: 43–46.

8. Maidannyk VH, Mytiuraeva-Korneiko YA. (2015). Kawasaki disease in childhood. Kiyv: Lohos.

9. Shostakovych-Koretskaia LR, Budaeva YV. (2013). Kawasaki's syndrome as a cause of prolonged fever in children. Aktualnaia infektolohyia. 1: 104–107.

10. Amano S, Hazama F, Kubagawa H et al. (1980). General pathology of Kawasaki disease. On the morphological alterations corresponding to the clinical manifestations. Acta Pathol Jpn. 30: 681. PMid:7446109

11. Belay ED, Maddox RA, Holman RC et al. (2006). Kawasaki syndrome and risk factors for coronary artery abnormalities: United States, 1994–2003. Pediatr Infect Dis. 25: 245–9. https://doi.org/10.1097/01.inf.0000202068.30956.16; PMid:16511388

12. Burgner D, Davila S, Breunis WB et al. (2009). A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. PLoS Genetics. 5: 1000319. https://doi.org/10.1371/journal.pgen.1000319; PMid:19132087 PMCid:PMC2607021

13. Burgner D, Hamden A. (2005). Kawasaki disease: what is the epidemiology telling us about the etiology? Int J Infect Dis. 9: 185. https://doi.org/10.1016/j.ijid.2005.03.002; PMid:15936970

14. Burns JC, Cayan DR, Tong G et al. (2005). Seasonality and temporal clustering of Kawasaki syndrome. Epidemiology. 16: 220. https://doi.org/10.1097/01.ede.0000152901.06689.d4; PMid:15703537 PMCid:PMC2894624

15. Burns JC, Glode MP. (2004). Kawasaki syndrome. Lancet. 364: 533. https://doi.org/10.1016/S0140-6736(04)16814-1

16. Chen S, Dong Y, Yin Y et al. (2013). Intravenous immunoglobulin plus corticosteroid to prevent coronary artery abnormalities in Kawasaki disease: a meta-analysis. Heart. 99: 76–82. https://doi.org/10.1136/heartjnl-2012-302126; PMid:22869678

17. Dergun M, Kao A, Hauger SB et al. (2005). Familial occurrence of Kawasaki syndrome in North. Pediatr Adolesc Med. 159: 876. https://doi.org/10.1001/archpedi.159.9.876; PMid:16143748 PMCid:PMC2910318

18. Diagnostic guidelines for Kawasaki disease. 5th edn. Japan Kawasaki Disease Research Committee (2002). Tokyo.

19. Du ZD, Zhao D, Du J et al. (2007). Epidemiologic study on Kawasaki disease in Beijing from 2000 through 2004. Pediatr Infect Dis J. 26: 449. https://doi.org/10.1097/01.inf.0000261196.79223.18; PMid:17468660

20. Fischer TK, Holman RC, Yorita KL et al. (2007). Kawasaki syndrome in Denmark. Pediatr Infect Dis J. 26: 411. https://doi.org/10.1097/01.inf.0000259964.47941.00; PMid:17468651

21. Galeotti C, Kaveri SV, Cimaz R, Koné-Paut I et al. (2016). Predisposing factors, pathogenesis and therapeutic intervention of Kawasaki disease. Drug Discov Today. 21(11): 1850–1857. https://doi.org/10.1016/j.drudis.2016.08.004; PMid:27506874

22. Hirata S, Nakamura Y, Yanagawa H. (2001). Incidence rate of recurrent Kawasaki disease and related risk factors: from the results of nationwide surveys of Kawasaki disease in Japan. Acta Paediatr. 90: 40. https://doi.org/10.1111/j.1651-2227.2001.tb00253.x; PMid:11227331

23. Holman RC, Curns AT, Belay ED et al. (2003). Kawasaki syndrome hospitalizations in the United States, 1997 and 2000. Pediatrics. 112: 495. https://doi.org/10.1542/peds.112.3.495; PMid:12949272

24. Huang WC, Huang LM, Chang IS et al. (2009). Epidemiologic features of Kawasaki disease in Taiwan, 2003-2006. Pediatrics. 123: 401. https://doi.org/10.1542/peds.2008-2187; PMid:19237439

25. Jennette JC, Falk RJ. (2007). The role of pathology in the diagnosis of systemic vasculitis. Clin Exp Rheumatol. 25: 52.

26. Kanecki K, Mikołajczyk M, Tyszko P. (2016). Kawasaki disease: increasing incidence in Poland. Scandinavian Journal of Rheumatology. 45; 1: 82–83. https://doi.org/10.3109/03009742.2015.1085082; PMid:26399391

27. Kao AS, Getis A, Brodine S, Burns JC. (2008). Spatial and temporal clustering of Kawasaki syndrome cases. Pediatr Infect Dis J. 27: 981. https://doi.org/10.1097/INF.0b013e31817acf4f; PMid:18852687 PMCid:PMC2870532

28. Kawasaki T. (1967). Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi. 16(3): 178. PMid:6062087

29. McCrindle et al. (2017). Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease. Circulation: 135.

30. Nakamura Y, Yashiro M, Uehara R et al. (2010). Epidemiologic features of Kawasaki disease in Japan: results of the 2007-2008 nationwide survey. J Epidemiol. 20(4): 302. https://doi.org/10.2188/jea.JE20090180; PMid:20530917 PMCid:PMC3900790

31. Newburger JW, Takahashi M, Gerber MA et al. (2004). Diagnosis, treatment, and longterm management of Kawasaki disease. Circulation. 110: 2747–71. https://doi.org/10.1161/01.CIR.0000145143.19711.78; PMid:15505111

32. Onouchi Y, Ozaki K, Burns JC et al. (2012). A genome-wide association study identifies three new risk loci for Kawasaki disease. Nat Genet. 44: 517–21. https://doi.org/10.1038/ng.2220; PMid:22446962

33. Schiller B, Fasth A, Bjorkhem G et al. (1995). Kawasaki disease in Sweden: incidence and clinical features. Acta Paediatr. 84(7): 769–774. https://doi.org/10.1111/j.1651-2227.1995.tb13753.x; PMid:7549295

34. Son MB, Gauvreau K, Ma L et al. (2009). Treatment of Kawasaki disease: analysis of 27 US pediatric hospitals from 2001 to 2006. Pediatrics. 124: 1. https://doi.org/10.1542/peds.2008-0730; PMid:19564276

35. Takahashi K, Oharaseki T, Yokouchi Y. (2011). Pathogenesis of Kawasaki disease. Clin Exp Immunol. 164; Suppl 1: 20. https://doi.org/10.1111/j.1365-2249.2011.04361.x; PMid:21447126 PMCid:PMC3095860

36. Tamburlini G, Strinati R, Cadorini S et al. (1984). A two-year survey of mucocutaneous lymph node syndrome in northeastern Italy. Epidemiological and clinical findings. Helv. Paediatr. Acta. 39: 319–329. PMid:6543845

37. Tremoulet AH, Best BM, Song S et al. (2008). Resistance to intravenous immunoglobulin in children with Kawasaki disease. J Pediatr. 153: 117–21. https://doi.org/10.1016/j.jpeds.2007.12.021; PMid:18571548 PMCid:PMC2526555