PERINATOLOGY AND PEDIATRIC. UKRAINE. 2017.3(71):25-31; doi 10.15574/PP.2017.71.25

Limanskaya А. Yu., Butenko L. P., Davydova I. V.
SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv, Ukraine

Objective — to study the efficacy of Neurocitin (Yuria-Pharm), an infusion solution of cyticoline and balanced composition of electrolytes, as a complex neuroprotection in the treatment of pregnant women with ischemic stroke in the acute period and in the period of early and late rehabilitation.
Material and methods. In order to achieve this goal, the patients' general condition was assessed using the appropriate widely used in the modern medicine scales, in particular, for assessment of the patient's physical status with ischemic stroke. The efficiency of Neurocitin (Yuria-Pharm) in the complex therapy of 5 pregnant women who had an ischemic stroke during pregnancy and 11 pregnants with a history of stroke (a late rehabilitation period) was investigated, but during the present pregnancy they had complaints that pointed to residual poststroke cognitive disorders. The drug was administered for 100 ml 2 times a day in form of intravenously infusion in an acute period, and 50—100 ml 2 times a day in infusions during the period of early and late poststroke rehabilitation. It should be noted that in acute phase of stroke the drug was administered from the first day of the disease.
Results. The administration of cyticoline contributed to the improvement of neurological symptoms in the acute period of ischemic stroke. The study showed the efficacy and safety of the use of cyticoline during the recovery period in the patients with mild poststroke neurodynamic violations of cognitive functions. Neurocitin (Yuria-Pharm) made it possible to achieve near-complete recovery of daily living activities and degree of functional recovery (according to the modified Rankin Scale <1 point) in women after ischemic stroke. Infusion solution Neurocitin (Yuria-Pharm) contributed to the restoration of the blood flow volume and the reduction of the toxic substances concentration and its effects on neurons due to the special drug composition, in particular, a balanced complex of electrolytes and cyticoline.
Conclusions. The drug has a proven risk-benefit profile and can be used in treatment of pregnant women in cases of medical necessity during the acute period of the disease and during the poststroke rehabilitation period.
Key words: pregnant women, cerebrovascular disorder, Neurocitin efficacy.

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