HEALTH OF WOMAN.2017.1(117):162–164

Eldar Aliyeva Shafag Kyzy, Hasanov Beybala Adalat Oglu Akhundov Natavan Eldar Kyzy
Azerbaijan Medical University, Baku

Object of the research. estimation of diagnostic significance of CA125, CEA and SCC oncomarkers at women at the reproductive period, who were put cervical intraepithelial neoplasia diagnosis by colposcopy and cytologic test, and being at the high risk group of uterine neck carcinoma.

Material and methods. In accordance with the object there were examined 20 women (main group) at the reproductive period (at the age of 18-45) entering in high risk group for uterine nect carcinoma. Comparison group consisted of 10 practically healthy women (control group). 5 (20%) of the women from the main group had polycystic ovary syndrome, 10 women (50%) –31.4±1.4 kg/m² body weght index, 5 women (20%) – sexually transmitted infections.

Results. Cytological test of uterine neck smear by Paponicolau method was conducted at all of these women and CIN-1 was detected at 13 of them (65%), and CЭN-2 – at 7 of them (35%). As a result of the research there was revealed that oncomarkers are significantly high at the women with detected CIN in comparison with the control group.

Conclusion Thereby, detection of oncomarkers during complex examination is important at cervical intraepithelial neoplasias, and it will help clinician doctors to choose their therapeutic approach.

Key words: dysplasia, cervical intraepithelial neoplasia, CIN, CA125, CEA, SCC, PAP-smear.

REFERENCES

1. Aliev OM, Bahshaliev AB, Alieva EM. 2005. Sostoyanie gipotalamogipofizarno-yaichnikovoy sistemyi u bolnyih stenokardiey v postmenopauzalnom periode. Sağlamlıq 2:27–30.

2. Amiraslanov AT, Kaziev AYu, Amiraslanov AA. 2006. Zabolevaemost zlokachestvennyimi novoobrazovaniyami naseleniya Azerbaydzhana v 2004. Materialyi IV s'ezda onkologov i radiologov SNG. Baku:4.

3. Kulakov VI, Apolihina IA, Prilepskaya VN i dr. 2000. Sovremennyie podhodyi k diagnostike papillomavirusnoy infektsii genitaliy u zhenschin i ih znachenie dlya skrininga raka sheyki. Ginekologiya 1;2:4–8.

4. Manuhin IB, Minkina GN, Arikova AL, Harlova OG. Sostoyanie mestnogo immuniteta u bolnyih s papillomavirusnoy infektsiey sheyki matki. Puti razvitiya sovremennoy ginekologii. Tez. Dokl. Vserossiyskoy nauch.-prakt. Konf., Moskva, 21-23 noyabrya 1995 g.: 68.

5. Manuhin IB, Minkina GN, Saprigina OA, Bagirova MO. 1993. Immunnyie mikrobiologicheskie aspektyi zabolevaniy sheyki matki. Sb. statey «Aktualnyie voprosyi klinicheskoy meditsinyi». M.

6. Tsvelev YuV, Kira EF, Ponomarenko GN, Gayvoronskih DI. 2001. Prakticheskiy spravochnik akushera-ginekologa. Sank-Peterburg: Foliant:330–340.

7. Əmiraslanova ShZ. 2009. Vaginal qanaxmasl olan qadinlarda usaqligin preinvaziv x`st`likl`rinin diaqnostikasinda muasir usullarin tetbiqi. Baki:131.

8. Əmiraslanov ƏT, Qaziyev AY. 2003. Usaq onkologiyasi. Baki, “maarif”, s`h 435–439.

9. Qaziyev AY. 2003. Azerbaycanda bedxass`li sisl`rin epidemiologiyasi, tibbi. Demoqrqfik v` sosial-iqtisadi itki, skrininq. Azerbaycan onkologiya ve h`mm`rz elml`r jurnali, Baki, cild 10, 2:37–46.

10. Coppleson LW, Brown B. Estimation of the training error rate from the observed detection rater in repeated cervical cytology.

11. Kok MR, Boon ME, Schreiner-Kok PG et al. 2001. Less medical intervention after sharp damarcation of grade 1-2 cervical intraepitelial neoplasia smears by neural network screening. Cancer 93:178. https://doi.org/10.1002/cncr.9026.abs; https://doi.org/10.1002/cncr.9026

12. Kwong J, Lo KW, To KF еt al. 2001. Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin. Can. Res. 8:131-137.

13. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. 1998. Alterations in DNA methylation; a fundamental aspect of neoplasia. Adv. Cancer. Res. 72:141–196. https://doi.org/10.1016/S0065-230X(08)60702-2

14. Massad LS, Collins YC, Mayer PM. 2001. Biopsy correlates of abnormal cervical cytology classified using the Bethesda system. Gynecol. Oncol. 82:516–522. https://doi.org/10.1006/gyno.2001.6323; PMid:11520149

15. Meijer CJ, Walboomers JM. 2000. Cervical cytology after 2000; where to go ? J.Clin.Pathol. 53:41–43. https://doi.org/10.1136/jcp.53.1.41; PMCid:PMC1731046

16. Obwegeser JH, Brack S. Does liquid- based technology really improve detection of cervical neoplasia? A prospective randomized trial comparing the Thin Prep Pap test with the conventional Pap test? Including follow-up of HSIL cases. Acto Cytol. 46:304–308.

17. Perspective Evaluation of 81 CA125 of early Detection of Orarian. Cancer Einhorn, Sjovall K., Knapp R.C. et al. Amer.J. obstet. Gynecol. 1992. 80:14–18.

Prevalence Sirevning for Ovarian cancer in Pastmenopausal Women by CA125 mensu rement and ultrasonography. Encobr J. Prys Davier A., Bridgez J.et al. Brit. Med. J. 1993. 306:1030–1034.