HEALTH OF WOMAN.-2017.1(117):81–84

Shapoval O. S., Vorontsova L. L.
SI «Zaporozhye Medical Academy of Postgraduate Education of Ministry of Health of Ukraine»

The objective: to identify effective treatment in parous women with ovarian endometriomas based on the characteristics of their immune status.

Patients and methods. 50 healthy non-pregnant women (control), 15 women with a confirmed diagnosis of ovarian endometrioma treated with a conventional treatment, 15 women with the same diagnosis who received comprehensive treatment, including immunomodulators and adaptogens. There were studied phagocytic activity of blood (NBT-test, stimulated NBT-test); myeloperoxidase activity of neutrophils; content of cationic proteins in neutrophils. Determination of subpopulations of lymphocytes was carried out using monoclonal antibodies against antigens CD3+, CD4+, CD8+, CD16+, CD19+. Determination of humoral immunity IgA, IgM, IgG was performed using monospecific sera against these immunoglobulin. Statistical data processing performed using computer software package STATISTICA (StatSoftStatistica v.6.0).

Results. In parous women with endometriomas on pretreatment stage irregularities were detected in the immune system, manifested by incomplete phagocytosis, decreased neutrophil microbicidal potential, increase in the number of B-lymphocytes and immunoglobulins of basic groups, indicating a violation of the immune mechanisms of protection of the woman’s body and confirmed their participation in the pathogenesis of the disease.

Conclusion. At the end of the traditional course of treatment microbicidal capacity of neutrophils has still been reduced and observed activation of humoral immune system, indicating the need for pathogenetic substantiation of medical immunocorrection. Following a comprehensive treatment the normalization of immunоhomeostasis of body was observed.

Key words: endometrioma, pregnancy, immunotherapy, immunodiagnostics.

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