• Вторичные опухоли головного мозга у детей, больных острым лимфобластным лейкозом, после программного лечения химиотерапией и лучевой терапией

Вторичные опухоли головного мозга у детей, больных острым лимфобластным лейкозом, после программного лечения химиотерапией и лучевой терапией

SOVREMENNAYA PEDIATRIYA.2018.3(91):74-85; doi 10.15574/SP.2018.91.74

Дорош О. И., Трояновська О. О., Абрамюк А. Н., Мелько И. П., Цымбалюк-Волошин И. П., Полищук Р. С.
КУ Львовского областного совета «Западноукраинский специализированный детский медицинский центр», Украина
Львовский национальный медицинский университет имени Данила Галицкого, Украина
Институт и поликлиника диагностической и интервенционной нейрорадиологии, г. Дрезден, Федеративная Республика Германия
Университетская клиника Carl Gustav Carus, г. Дрезден, Федеративная Республика Германия
Технический университет, г. Дрезден, Федеративная Республика Германия
Институт публичного права Свободной Саксонии, г. Дрезден, Федеративная Республика Германия
Центр медицинских инноваций «NOVO», г. Львов, Украина

Представлены результаты наблюдения трех пациентов с вторичными опухолями головного мозга (ВОГМ) — фибринозная астроцитома, олигодендроглиома, доброкачественная менингиома, диагностированными через 6 лет 1 месяц, 7 лет, 7,5 лет соответственно после завершения программного лечения острой лимфобластной лейкемии (ОЛЛ). Это составило 1,01% из 298 живых детей в возрасте до 18 лет с первично диагностированным ОЛЛ, получивших лечение в отделении гематологии и интенсивной химиотерапии ЗУСДМЦ в период с февраля 1993 г. по январь 2018 г. согласно программам химиотерапии ALL-BFM и INTRFANT-99/06. В соответствии с требованиями протокольного лечения химиотерапия применялась и в лечении части больных — облучение центральной нервной системы. Проведенный анализ свидетельствует, что благодаря современной терапии уровень заболеваемости вторичными опухолями после инициального лечения ОЛЛ остается низким на протяжении 25 лет наблюдения. Полученные результаты сопоставлены с данными других онкогематологических центров.

Ключевые слова: дети, острый лимфобластный лейкоз, вторичная опухоль головного мозга, химиотерапия, лучевая терапия.

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