• Вклад натурального ауто-IgM во врожденный иммунитет

Вклад натурального ауто-IgM во врожденный иммунитет

PERINATOLOGY AND PEDIATRIC. UKRAINE. 2018.2(74):45-51; doi 10.15574/PP.2018.74.45

Макаренко М. В., Говсеев Д. А., Сокол И. В., Берестовый В. О., Мартич А. Н., Ворона Р. Н.
Национальный медицинский университет имени А.А. Богомольца, г. Киев, Украина

Натуральные ауто-IgM синтезируются в B1-клетках (CD5+ мыши; CD20+CD27+CD43+CD70 — у людей) и играют существенную роль в защите организма от вторжения антигенов разного генеза, поддерживают иммунохимический гомеостаз организма, регулируя клиренс апоптических клеток, выполняют противовоспалительную функцию, регулируют аутореактивные антитела и удаляют протеины с незавершенным или дефектным фолдингом. Эти наблюдения стали толчком для поиска путей терапевтического применения натуральных ауто-IgM, увеличения их количества in vivo, а также применения моноклональных и поликлональных препаратов IgM.
Ключевые слова: натуральные ауто-IgM антитела, иммунитет, В1-клетки.

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