• Важность и значение полиморфизма генов при преэклампсии 
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Важность и значение полиморфизма генов при преэклампсии 

HEALTH OF WOMAN. 2016.8(114):45–49; doi 10.15574/HW.2016.114.45 
 

Важность и значение полиморфизма генов при преэклампсии 
 

Веропотвелян П. Н., Цехмистренко И. С., Веропотвелян Н. П., Русак Н. С., Горук П. С.

ОКУ«Межобластной центр медицинской генетики и пренатальной диагностики», г. Кривой Рог

Перинатальный центр, г. Киев

КУ «Криворожский городской клинический родильный дом № 1» ДОС»


В статье приведен систематический обзор данных о взаимосвязи между полиморфизмами генов системы детоксикации и развитием преэклампсии (ПЭ). Описаны основные гены системы детоксикации (GSTPI,

GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) и их функции. Представляет интерес возможность расчета индивидуального риска развития ПЭ на основании данных о наличии сочетаний разных полиморфизмов в генотипе женщины. Вопрос о ранней диагностике ПЭ остается дискутабельным и до конца не изученным. Необходимо проводить дальнейшее углубленное расширенное исследование данной проблемы.


Ключевые слова: преэклампсия, окислительный стресс, гены системы детоксикации.


Литература:

1. Also-Rallo E. Polymorphisms of genes involved in homocysteine metabolism in preeclampsia and in uncomplicated pregnancies /E. Lopez-Quesada, R. Urreizti, M.A. Vilaseca, J.M. Lailla, S. Balcells, D. Grinberg //Eur. J. Obstet. Gynecol. Reprod. Biol. – 2005. – V. 120 (1). – P. 45–52.

2. Das B. Assessment of placental oxidative stress in pre-eclampsia /S. Saha-Roy, A. Das Gupta, T.K. Lahiri, H.N. Das //J. Obstet. Gynaecol. India. – 2012. – V. 62 (1). – P. 39–42.

3. Zusterzeel P.L. N-acetyl-transferase phenotype and risk for preeclampsia /R.H. te Morsche, M.T. Raijmakers, E.M. Roes, W.H. Peters, R.P. Steegers-Theunissen, E.A. Steegers /Am. J. Obstet. Gynecol. – 2005. – V. 193(3, Pt 1). – P. 797–802.

4. Jobe S.O. Estradiol-17в and its cytochrome P450-and catechol-O- methyltransferase-derived metabolites stimulate proliferation in uterine artery endothelial cells: role of estrogen receptor-б versus estrogen receptor-в /J. Ramadoss, J.M. Koch, Y. Jiang, J. Zheng, R.R. Magness /Hypertension. – 2010. – V. 55(4). – P. 1005–11. https://doi.org/10.1161/HYPERTENSIONAHA.109.146399; PMid:20212268 PMCid:PMC2876348

5. Laraqui A. Relation between plasma homocysteine, gene polymorphisms of homocysteine metabolism-related enzymes, and angiographically proven coronary artery disease /A. Allami, A. Carrie, A. Raisonnier, A.S. Coiffard, F. Benkouka et al. //Eur. J. Intern. Med. – 2007. – V. 18(6). – P. 474–83.

6. Murakami S. The relation between plasma homocysteine concentration and methylenetetrahydrofolate reductase gene polymorphism in pregnant women /N. Matsubara, M. Saitoh, S. Miyakaw, M. Shoji, T. Kubo //J. Obstet. Gynaecol. Res. -2001. – V. 27(6). – P. 349–52.

7. Al-Jameil N. A brief overview of preeclampsia /F. Aziz Khan, M. Fareed, H. Tabassum //J Clin Med Res. – 2014. – V. 6 (1). – P. 1–7.

8. Wu X. Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis /K. Yang, X. Tang, Y. Sa, R. Zhou, J.Liu et al //J. Assist. Reprod. Genet. – 2015. – V. 32 (5). – P. 797–805. https://doi.org/10.1007/s10815-014-0408-8

9. Li X. Methylenetetrahydrofolate reductase gene C677T, A1298C polymorphisms and pre-eclampsia risk: a meta-analysis /Y.L. Luo, Q.H. Zhang, C. Mao, X.W. Wang, S. Liu, Q. Chen //Mol. Biol. Rep. – 2014. – V. 41 (8). – P. 5435–48. https://doi.org/10.1007/s11033-014-3415-z

10. Salimi S. The early-onset preeclampsia is associated with MTHFR and FVL polymorphisms /M. Saravani, M. Yaghmaei, Z. Fazlali, M. Mokhtari, A. Naghavi, F. Farajian-Mashhadi //Arch. Gynecol. Obstet. – 2015. – V. 291 (6). – P. 1303–12.

11. Kan N.E. The significance of polymorphisms genes of detoxification system in preeclampsia /L.A. Bednyagin, V.L. Tyutyunnik et. al. //Obstetrics and gynecology. -2016. – V. 2. – P. 8–13. https://doi.org/10.18565/aig.2016.2.8-13

12. Perez-Sepulveda A. Levels of key enzymes of methionine-homocysteine metabolism in preeclampsia /P.P. Espana-Perrot, X.B. Fernandez, V. Ahumada, V. Bustos, J.A. Arraztoa et al. // Biomed. Res. Int. – 2013. – V. 2013. – P. 8.

13. Seremak-Mrozikiewicz A. The importance of MTHFR, MTR, MTRR and CSE expression levels in Caucasian women with preeclampsia /A. Bogacz, J. Bartkowiak-Wieczorek, H. Wolski, B. Czerny, M. Gorska-Paukszta, K. Drews //Eur. J. Obstet. Gynecol. Reprod. Biol. – 2015. – V. 188 (5). – P. 113–7.

14. Hong Y.C. Genetic susceptibility of term pregnant women to oxidative damage /K.H. Lee, C.H. Yi, E.H. Ha, D.C. Christiani //Toxicol. Lett. – 2002. – V. 129 (3). – P. 255–62.

15. Procopciuc L.M. The Ala-9Val (Mn-SOD) and Arg213Gly (EC-SOD) polymorphisms in the pathogenesis of preeclampsia in Romanian women: association with the severity and outcome of preeclampsia /G. Caracostea, G. Nemeti, C. Drugan, I. Olteanu, F.J. Stamatian //Matern. Fetal Neonatal Med. – 2012. – V. 25 (7). – P. 895–900. https://doi.org/10.3109/14767058.2011.599078; PMid:22432908

16. Rosta K. Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction /A. Molvarec, A. Enzsoly, B. Nagy, Z. Rуnai, A. Fekete et al. //Eur. J. Obstet. Gynecol. Reprod. Biol. – 2009. – V. 142 (2). – P. 134–8.

17. James P.R. Management of hypertension before, during and after pregnancy /C. Nelson-Piercy //Heart. – 2004. – V. 90 (12). – P. 1499-504. https://doi.org/10.1136/hrt.2004.035444; PMid:15547046 PMCid:PMC1768605

18. Redman C.W. Placental stress and pre-eclampsia: a revised view /I.L. Sargent //Placenta. -2009. – V. 30(Suppl.А). – P. 38–42.

19. Cronqvist T. Syncytiotrophoblast vesicles show altered micro-RNA and haemoglobin content after ex-vivo perfusion of placentas with haemoglobin to mimic preeclampsia /K. Salje, M. Familari, S. Guller, H. Schneider, C. Gardiner et al. //PLoS One. – 2014. – V. 9 (2). -e90020.

20. Hansson S.R. Oxidative stress in preeclampsia and the role of free fetal hemoglobin /A. Naav, L. Erlandsson //Front. Physiol. – 2015. – V. 5. – P. 516.

21. Walsh S.W. Maternal-placental interactions of oxidative stress and antioxidants in preeclampsia //Semin. Reprod. Endocrinol. – 1998. – V. 16 (1). – P. 93–104.

22. The National Center for Biotechnology Information Gene Database. http: //www. ncbi. nlm. nih.gov/gene

23. OMIM: An Online Catalog of Human Genes and Genetic Disorders. http://www.omim.org

24. Zusterzeel P.L. Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes /W.H. Peters, G.J. Burton, W. Visser, H.M. Roelofs, E.A. Steegers //Gynecol. Obstet. Invest. – 2007. – V. 63 (4). – P. 209–13.

25. Canto P. Methylenetetrahydrofolate reductase C677T and glutathione S-transferase P1 A313G are associated with a reduced risk of preeclampsia in Maya-Mestizo women /T. Canto-Cetina, R. Juarez-Velazquez, H. Rosas-vargas, H.H. Rangel-Villalobos, S. Canizales-Quinteros et al. //Hypertens. Res. – 2008. – V. 31 (5). – P. 1015–9.

26. Gebhardt G.S. Maternal and fetal single nucleotide polymorphisms in the epoxide hydrolase and gluthatione S-transferase P1 genes are not associated with pre-eclampsia in the Coloured population of the Western Cape, South Africa /W.H. Peters, R. Hillermann, H.J. Odendaal, K. Carelse-Tofa, M.T. Raijmakers, E.A. Steegers //J. Obstet. Gynaecol. — 2004. – V. 24 (8). – P. 866–72.

27. Coral-Vбzquez R.M. Analysis of polymorphisms and haplotypes in genes associated with vascular tone, hypertension and oxidative stress in Mexican-Mestizo women with severe preeclampsia /J.F. Romero Arauz, S. Canizales-Quinteros, A. Coronel, E.Y. Valencia, J. Hernбndez Rivera et al. //Clin. Biochem. – 2013. – V. 46 (7–8). – P. 627–32.

28. Norppa H. Genetic susceptibility, biomarker respones, and cancer //Mutat. Res.- 2003. – V. 544 (2–3). – P. 339–48.

29. Sandoval-Carrillo A. Polymorphisms in the GSTT1 and GSTM1 genes are associated with increased risk of preeclampsia in the Mexican mestizo population /M. Aguilar-Duran, F. Vбzquez-Alaniz, F.X. Castellanos-Juбrez, M. Barraza-Salas, E. Sierra-Campos et al. //Genet. Mol. Res. – 2014. – V. 13 (1). – P. 2160–5.

30. Zhang J. Placental anti-oxidant gene polymorphisms, enzyme activity, and oxidative stress in preeclampsia /M. Masciocchi, D. Lewis, W. Sun, A. Liu, Y. Wang //Placenta. – 2008. – V. 29 (5). – P. 439–43. https://doi.org/10.1016/j.placenta.2008.02.012; PMid:18387669 PMCid:PMC2570102

31. Atalay M.A. Polymorphisms in angiotensin-converting enzyme and glutathione s-transferase genes in Turkish population and risk for preeclampsia /K. Ozerkan, M. Karkucak, T. Yakut, Y. Atik, O.H. Develioglu //Clin. Exp. Obstet. Gynecol. — 2012. – V. 39 (4). – P. 466–9.

32. Kim Y.N. Toward a better understanding of preeclampsia: Comparative proteomic analysis of preeclamptic placentas /H.K. Kim, M. Warda, N. Kim, W.S. Park, B. Prince Adel et al. // Proteomics Clin. Appl. — 2007. – V. 1 (12). – P. 1625–36. https://doi.org/10.1002/prca.200700034

33. Mistry H.D. Association between maternal micronutrient status, oxidative stress, and common genetic variants in antioxidant enzymes at 15 weeks gestation in nulliparous women who subsequently develop preeclampsia /C.A. Gill, L.O. Kurlak, P.T. Seed, J.E. Hesketh, C. Meplan et al. //Free Radic. Biol. Med. – 2015. – V.78. – P.147-55. https://doi.org/10.1016/j.freeradbiomed.2014.10.580; PMid:25463281 PMCid:PMC4291148

34. Sukhikh G.T. Apoptosis and gene expression of antioxidant enzymes in the placenta in preeclampsia /A.M. Krasny, N.E. Kahn et al. //Obstetrics and gynecology. – 2015. – V. 3. – P. 11–5.

35. Mistry H.D. Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy /L.O. Kurlak, P.J. Williams, M.M. Ramsay, M.E. Symonds, F. Broughton Pipkin //Placenta. – 2010. – V. 31 (5). – P. 401–8. https://doi.org/10.1016/j.placenta.2010.02.011; PMid:20303587

36. Roland-Zejly L. Altered placental glutathione peroxidase mRNA expression in preeclampsia according to the presence or absence of labor /V. Moisan, I. St-Pierre, J.F. Bilodeau //Placenta. – 2011. – V.32(2). – P. 161–7. https://doi.org/10.1016/j.placenta.2010.11.005; PMid:21145108

37. Mistry H.D. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies /V. Wilson, M.M. Ramsay, M.E. Symonds, F. Broughton Pipkin //Hypertension. – 2008. – V. 52 (5). – P. 881–8. https://doi.org/10.1161/HYPERTENSIONAHA.108.116103; PMid:18852388

38. Yan J. Relationships between concentrations of free fatty acid in serum and oxidative-damage levels in placental mitochondria and preeclampsia /X. Xu //Zhonghua Fu Chan Ke Za Zhi. – 2012. – V. 47 (6). – P. 412–7.

39. Groten T. eNOSI4 and EPHX1 polymorphisms affect maternal susceptibility to preeclampsia: analysis of five polymorphisms predisposing to cardiovascular disease in 279 Caucasian and 241 African women /E. Schleussner, T. Lehmann, F. Reister, B. Holzer, K.A. Danso, R. Zeillinger //Arch. Gynecol. Obstet. – 2014. – V. 289 (3). – P. 581–93. https://doi.org/10.1007/s00404-013-2991-9

40. Laasanen J. Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia /E.L. Romppanen, M. Hiltunen, S. Heli-salmi, A. Mannermaa, K. Punnonen, S. Heinonen //Eur. J. Hum. Genet. – 2002. – V. 10 (9). – P. 569–73.

41. Pinarbasi E. Association of microsomal epoxide hydrolase gene polymorphism and pre-eclampsia in Turkish women /F.E. Percin, M. Yilmaz, E. Akgun, M. Cetin, A. Cetin //J. Obstet. Gynaecol. Res. – 2007. – V. 33 (1). – P. 32–7.

42. Wang Y. Increased superoxide generation is associated with decreased superoxide dismutase activity and mRNA expression in placental trophoblast cells in pre-eclampsia /S.W. Walsh //Placenta. – 2001. – V. 22 (2–3). – P. 206–12.

43. https://www.obs-gyn.ox.ac.uk

44.Lissette C. Sбnchez-Aranguren. Endothelial dysfunction and preeclampsia: role of oxidative stress /E. Carlos Prada //Front. Physiol., 10 October 2014.