SOVREMENNAYA PEDIATRIYA.2016.5(77):54-61; doi10.15574/SP.2016.77.54 

Розвиток імунної відповіді при пневмококовій пневмонії. Частина 2 

Абатуров О. Є., Агафонова О. О., Нікуліна А. О.

ДЗ «Дніпропетровська медична академія МОЗ України», Дніпро, Україна 

Стаття присвячена вивченню ролі різних цитокінів (IL-1β, IL-6, IL-8, IL-10, IL-17, TNF-α, інтерферонів I і II типів) у розвитку запального процесу при пневмококовій пневмонії. Представлена характеристика сімейств интерлейкінів, хемокінів, інтерферонів, що беруть участь у формуванні адекватного запального процесу і неспецифічній імунній відповіді, спрямованій на елімінацію Streptococcus pneumoniae. Показано активну участь интерферонової системи в антибактеріальному захисті (у рекогніції, процесингу, презентації антигена, трансдукції внутрішньоклітинного сигналу, активації факторів транскрипції, продукції цитокінів).

Ключові слова: пневмококова пневмонія, імунна відповідь, цитокіни, інтерферони.

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