• Патофізіологічні механізми розвитку колоїдних рубців у дітей (огляд літератури)

Патофізіологічні механізми розвитку колоїдних рубців у дітей (огляд літератури)

Paediatric Surgery.Ukraine.2017.1(54):97-101; doi 10.15574/PS.2017.55.97

Боднар Б. М., Левицька С. А.
ВДН З «Буковинський державний медичний університет», м.Чернівці, Україна

Наведено огляд сучасних даних літератури про основні патофізіологічні механізми розвитку та особливості розвитку келоїдних рубців у дітей. Систематизовано основні теорії щодо утворення келоїдних рубців, проведено аналіз наукових праць останніх років щодо спадкових і набутих патогенетичних чинників їх виникнення.

Ключові слова: келоїдні рубці, діти, патогенез.

Література

1. Huang C, Liu L, You Z, Wang B, Du Y et al. 2016, Dec. 19. Keloid progression: a stiffness gap hypothesis. Int Wound J [Internet]. Available from: http://onlinelibrary.wiley.com. doi 10.1111/iwj.12693.

2. Guy WM, Pattisapu P, Ongkasuwan J, Brissett AE. 2015, Dec. Creation of a head and neck Keloid quality of life questionnaire. Laryngoscope [Internet]. 125(12): 2672-6. Available from: https://www.ncbi.nlm.nih.gov/pubmed /26421904/. https://doi.org/10.1002/lary.25309.

3. Daegu S, Aram H. 2014, Jun. Overview of Surgical Scar Prevention and Management J Korean Med Sci [Internet]. 29(6): 751–757. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24932073. doi 10.3346/jkms.2014.29.6.751.

4. Philandrianos C, Kerfant N, Jaloux C Jr, Martinet L, Bertrand B, Casanova D. 2016, Apr. Keloid scars (part I): Clinical presentation, epidemiology, histology and pathogenesis. Ann Chir Plast Esthet [Internet]. 61(2): 128-35. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26545809. https://doi.org/10.1016/j.anplas.2015.09.005.

5. Fuentes-Duculan J, Bonifacio KM, Suarez-Farinas M, Kunjravia N, Garcet S, Cruz T et al. 2016, Dec. 11. Aberrant connective tissue differentiation towards cartilage and bone underlies human keloids in African Americans. Exp Dermatol [Internet]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27943413. doi 10.1111/exd.13271.

6. Kiprono SK, Chaula BM, Masenga JE, Muchunu JW, Mavura DR, Moehrle M. 2015, Sep. Epidemiology of keloids in normally pigmented Africans and African people with albinism: population-based cross-sectional survey. Br J Dermatol [Internet]. 173(3): 852-4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25833201. https://doi.org/10.1111/bjd.13826.

7. Chong Y, Park TH, Seo Sw, Chang CH. 2015, Mar. Histomorphometric analysis of collagen architecture of auricular keloids in an Asian population. Dermatol Surg [Internet]. 41(3): 415-22. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25738446. doi 10.1097/DSS.0000000000000176.

8. Shaheen A, Khaddam J, Kesh F. 2016, Sep. 20. Risk factors of keloids in Syrians. BMC Dermatol [Internet]. 16(1): 13. Available from: https://bmcdermatol.biomedcentral.com/articles/10.1186/s12895-016-0050-5. https://doi.org/10.1186/s12895-016-0050-5.

9. Lu WS, Zheng XD, Yao XH, Zhang LF. 2015, Mar. Clinical and epidemiological analysis of keloids in Chinese patients. Arch Dermatol Res [Internet]. 307(2): 109-14. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25266787. doi 10.1007/s00403-014-1507-1.

10. Ayanlowo OO, Gold-Olufadi SA, Akinkugbe AO, Otrofanowei E, Nga CN, Olumide YM. 2017, Jan. 31. Growing trend of tattooing and its complications in Nigeria. Int J Dermatol [Internet]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/28138959. https://doi.org/10.1007/s00403-014-1507-1.

11. Tirgan MH, Shutty CM, Park TH. 2013, Jan. Nine-month-old patient with bilateral earlobe keloids. Pediatrics [Internet]. 131(1): e313-7. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23248221. https://doi.org/10.1542/peds.2012-0075.

12. Sanchez J, Antonicelli F, Tuton D, Mazouz Dorval S, Francois C. 2016, Oct. Specificities in children wound healing. Ann Chir Plast Esthet [Internet]. 61(5): 341-347. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27289548. https://doi.org/10.1016/j.anplas.2016.05.001.

13. Zhang GY, Wu LC, Liao T, Chen G, Chen YH, Meng XC et al. 2016, Mar. Altered circulating endothelial progenitor cells in patients with keloid. Clin Exp Dermatol [Internet]. 41(2): 152-5. Available from: https://www.ncbi.nlm.nih. gov/pubmed/26121920. https://doi.org/10.1111/ced.12695.

14. Asadi M, Alamdari DH, Rahimi HR, Aliakbarian M, Jangjoo A, Abdollahi A. 2014, Aug. Treatment of life-threatening wounds with a combination of allogenic platelet-rich plasma, fibrin glue and collagen matrix, and a literature review. Exp Ther Med. [Internet]. 8(2): 423-429. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25009595. https://doi.org/10.3892/etm.2014.1747; PMid:25009595 PMCid:PMC4079439

15. Kuwahara H, Tosa M, Egawa S, Murakami M, Mohammad G, Ogawa R. 2016, Nov, 28. Examination of Epithelial Mesenchymal Transition in Keloid Tissues and Possibility of Keloid Therapy Target. Plast Reconstr Surg Glob Open. [Internet]. 4(11): e1138. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142499.

16. Touchi R, Ueda K, Kurokawa N, Tsuji M. 2016, Feb. Central regions of keloids are severely ischaemic. J Plast Reconstr Aesthet Surg. [Internet]. 69(2): e35-41. Available from: http://www.jprasurg.com/article/S1748-6815(15)00552-5/abstract. https://doi.org/10.1016/j.bjps.2015.11.006.

17. Chong Y, Park TH, Seo Sw, Chang CH. 2015, Mar. Histomorphometric analysis of collagen architecture of auricular keloids in an Asian population. Dermatol Surg. [Internet]. 41(3): 415-22. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25738446. doi 10.1097/DSS.0000000000000176.

18. Al-Attar A, Mess S, Thomassen JM, Kauffman CL, Davison SP. 2006. Keloid pathogenesis and treatment. Plastic Reconstr Surg. [Internet]. 117(1): 286–300. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16404281. https://doi.org/10.1097/01.prs.0000195073.73580.46; PMid:16404281

19. Hahn JM, McFarland KL, Combs KA. 2016. Partial epithelialmesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1. Supp Burns Trauma. [Internet]. 4(1): 30. Published online 2016, Aug. 23. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994224/. https://doi.org/10.1186/s41038-016-0055-7; PMid:27574697 PMCid:PMC4994224

20. Fuentes-Duculan J, Bonifacio KM, Suarez-Farinas M, Kunjravia N, Garcet S, Cruz T et al. 2016, Dec. 11. Aberrant connective tissue differentiation towards cartilage and bone underlies human keloids in African Americans. Exp Dermatol. [Internet]. Available from: http://onlinelibrary.wiley.com/doi/10.1111/exd.13271/abstract. doi 10.1111/exd.13271.

21. Liu W, Huang X, Liang X, Zhou Y, Li H, Yu Q et al. 2017, Feb. Identification of Key Modules and Hub Genes of Keloids with Weighted Gene Coexpression Network Analysis. Plast Reconstr Surg. [Internet]. 139(2): 376-390. Available from: doi 10.1097/PRS.0000000000003014.

22. Halim AS, Emami A, Salahshourifar I, Kannan TP. 2012, May. Keloid Scarring: Understanding the Genetic Basis, Advances, and Prospects. Arch Plast Surg. [Internet]. 39(3): 184–189. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385329/. https://doi.org/10.5999/aps.2012.39.3.184

23. Clark JA, Turner ML, Howard L, Stanescu H, Kleta R, Kopp JB. 2009. Description of familial keloids in five pedigrees: evidence for autosomal dominant inheritance and phenotypic heterogeneity BMC Dermatol. [Internet]. 9: 8. Published online 2009, Jul. 28. Available from: http://bmcdermatol.biomedcentral.com/articles/10.1186/1471-5945-9-8. https://doi.org/10.1186/1471-5945-9-8.

24. Edwards DRV, Tsosie K, Williams SM, Edwards TL, Russel SB. 2014, Dec. Admixture mapping identifies a locus at 15q21.2-22.3 associated with keloid formation in African Americans. Hum Genet. Author manuscript; available in PMC 2015 Feb 19. Published in final edited form as: Hum Genet [Internet]. 133(12): 1513–1523. Published online 2014, Oct. 4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25280642. https://doi.org/10.1007/s00439-014-1490-9.

25. Kumar S, Suthar R, Panigrahi I, Marwaha RK. 2012, May-Aug. Rubinstein-Taybi syndrome: Clinical profile of 11 patients and review of literature Indian J Hum Genet. [Internet]. 18(2): 161–166. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724379/. https://doi.org/10.4103/0971-6866.100751.

26. Bloor BK, Tidman N, Leigh IM, Odell E, Dogan B, Wollina U. 2003, Mar. Expression of Keratin K2e in Cutaneous and Oral Lesions: Association with Keratinocyte Activation, Proliferation, and Keratinization. Am J Pathol. [Internet]. 162(3): 963–975. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868097. https://doi.org/10.1016/S0002-9440(10)63891-6.

27. Liew WKM, Darras BT. 2013, Aug. 13. Teaching NeuroImages: Characteristic phenotype of Ullrich congenital muscular dystrophy Neurology. [Internet]. 81(7): e44–e45. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775691/. https://doi.org/10.1212/WNL.0b013e3182a08d13.

28. Dohi T, Miyake K, Aoki M, Ogawa R, Akaishi S, Shimada T et al. 2015, Sep. Tissue Inhibitor of Metalloproteinase-2 Suppresses Collagen Synthesis in Cultured Keloid Fibroblasts. Plast Reconstr Surg Glob Open. [Internet]. 3(9): e520. Published online 2015, Sep. 22. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596445/. https://doi.org/10.1097/GOX.0000000000000503.

29. Smith JC, Boone BE, Opalenik SR, Williams SM, Shirley B, Russell SB. 2010, Sep. 3. Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways. J Invest Dermatol. [Internet]. Author manuscript; available in PMC. Published in final edited form as: J Invest Dermatol. 2008, May. 128(5): 1298–1310. Published online 2007,Nov. 8. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17989729. doi 10.1038/sj.jid.5701149.

30. Zhu F, Wu B, Li P, Wang J, Tang H, Liu Y et al. 2013. Association Study Confirmed Susceptibility Loci with Keloid in the Chinese Han Population. PLoS One. [Internet]. 8(5): e62377. Published online 2013, May 7. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23667473. https://doi.org/10.1371/journal.pone.0062377.

31. Kelly AP. 2004. Medical and surgical therapies for keloids. Dermatol Ther. [Internet]. 17: 212–218. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15113289. doi 10.1111/j.1396-0296.2004.04022.

32. Arima J, Huang C, Rosner B, Akaishi S, Ogawa R. 2015, Mar.-Apr Hypertension: a systemic key to understanding local keloid severity. Wound Repair Regen. [Internet]. 23(2): 213-21. Available from: https://www.ncbi.nlm.nih. gov/pubmed/25728259. https://doi.org/10.1111/wrr.12277.

33. Berman B, Maderal A, Raphael B. 2017, Jan. Keloids and Hypertrophic Scars: Pathophysiology, Classification, and Treatment. Dermatol Surg. [Internet]. 43; Suppl. 1: S3-S18. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27347634. https://doi.org/10.1097/DSS.0000000000000819.

34. Suarez E, Syed F, Rasgado TA, Walmsley A, Mandal P, Bayat A. 2014, Sep.-Oct. Skin equivalent tensional force alters keloid fibroblast behavior and phenotype. Wound Repair Regen. [Internet]. 22(5): 557-68. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25046655. https://doi.org/10.1111/wrr.12215.

35. Ogawa R, Akaishi S, Hyakusoku H. 2009, Jun. Differential and exclusive diagnosis of diseases that resemble keloids and hypertrophic scars. Ann Plast Surg. [Internet]. 62(6): 660-4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/19461281. https://doi.org/10.1097/SAP.0b013e31817e9d67.

36. Ueda K, Yasuda Y, Furuya E, Oba S. 2004. Inadequate blood supply persists in keloids. Scand J Plast Reconstr Surg Hand Surg. [Internet]. 38(5): 267-71. Available from: https://www.ncbi.nlm.nih.gov/pubmed/15513596. https://doi.org/10.1080/02844310410029552; PMid:15513596

37. Ueda K, Furuya E, Yasuda Y, Oba S, Tajima S. 1999, Sep. Keloids have continuous high metabolic activity. Plast Reconstr Surg. [Internet]. 104(3): 694-8. Available from: https://www.ncbi.nlm.nih.gov/pubmed/10456520. https://doi.org/10.1097/00006534-199909010-00012; PMid:10456520

38. Jiao H, Fan J, Cai J, Pan B, Yan L, Dong P et al. 2015, Oct. Analysis of Characteristics Similar to Autoimmune Disease in Keloid Patients. Aesthetic Plast Surg. [Internet]. 39(5): 818-25. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26296635. doi 0.1007/s00266-015-0542-4.

39. Seleit I, Bakry OA, Samaka RM, Tawfik AS. 2016, Apr. Immunohistochemical Evaluation of Leptin Expression in Wound Healing: A Clue to Exuberant Scar Formation. Appl Immunohistochem Mol Morphol. [Internet]. 24(4): 296-306. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26258753. https://doi.org/10.1097/PAI.0000000000000187.

40. Huang C, Ogawa R. 2013, May 1. Roles of lipid metabolism in keloid development. Lipids Health Dis. [Internet]. 12: 60. Available from: https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-12-60. https://doi.org/10.1186/1476-511X-12-60.

41. Jumper N, Paus R, Bayat A. 2016, Feb. 5. An Innovative Approach to Dissecting Keloid Disease Leading to Identification of the Retinoic Acid Pathway as a Potential Therapeutic Target. Plast Reconstr Surg Glob Open. [Internet]. 4(1): e601. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801097. https://doi.org/10.1097/GOX.0000000000000589