• Білки теплового шоку у діагностиці та прогнозуванні порушень репродуктивної функції у жінок

Білки теплового шоку у діагностиці та прогнозуванні порушень репродуктивної функції у жінок

HEALTH OF WOMAN. 2018.7(133):77–83; doi 10.15574/HW.2018.133.77

Яковенко Л. Ф. , Ромащенко О. В., Крупська І. В.
Інститут молекулярної біології і генетики НАН України, м. Київ
Інстититут урології НАМН України, м. Київ

Білки теплового шоку (Heat shock proteins – HSPs) – висококонсервативні білки, які у збільшеній кількості синтезуються прокаріотичними та еукаріотичними клітинами за наявності стресових умов. HSPs є імунодомінантними антигенами бактерій, розпізнаються імунною системою і спричинюють розвиток реакцій клітинного та гуморального імунітету. Їхній рівень зростає у місцях гострого та хронічного запалення, вони залучені у патогенез практично всіх захворювань.

Огляд присвячено оцінюванню діагностичного потенціалу HSPs та анти-HSPs-антитіл для визначення стану репродуктивної функції у жінок за даними літератури та результатами власних досліджень. Також розглядаються можливі механізми залучення HSPs та анти-HSPs-антитіл у розвиток трубної безплідності, ранньої недостатності яєчників, процесу втрати вагітності на ранніх термінах.

Ключові слова: білки теплового шоку, антитіла проти білків теплового шоку, безплідність, невиношування вагітності, допоміжні репродуктивні технології.

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