HEALTH OF WOMAN. 2016.9(115):129–141 
 

Королевский колледж акушеров-гинекологов Великобритании «Эпилепсия во врем беременности» 
 

Руководство №68. Июнь 2016. Королевский колледж акушеров-гинекологов Великобритании. https://www.rcog.org.uk/globalassets/documents/guidelines/green-top-guidelines/gtg68_epilepsy.pdf

Печатается с сокращениями. Адаптировано – С.А. Шурпяк

Литература: 
1. National Institute for Health and Care Excellence. The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care. NICE clinical guideline 137. [Manchester]: NICE; 2012.

2. Scottish Intercollegiate Guidelines Network. Diagnosis and management of epilepsy in adults: A national clinical guideline. SIGN publication no. 143. Edinburgh: SIGN; 2015.

3. Edey S, Moran N, Nashef L. SUDEP and epilepsy-related mortality in pregnancy. Epilepsia 2014;55:e72–4. https://doi.org/10.1111/epi.12621; PMid:24754364

4. UK Epilepsy and Pregnancy Register [http://www.epilepsy andpregnancy.co.uk/]. Accessed 2016 Jan 6.

5. Adab N, Chadwick DW. Management of women with epilepsy during pregnancy. The Obstetrician & Gynaecologist 2006;8:20–5. https://doi.org/10.1576/toag.8.1.020.27204

6. Knight M, Kenyon S, Brocklehurst P, Neilson J, Shakespeare J, Kurinczuk JJ (Eds.) on behalf of MBRRACE-UK. Saving Lives, Improving Mothers’ Care: Lessons learned to inform future maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and. Morbidity 2009–12. Oxford: National Perinatal Epidemiology Unit; 2014 [https://www.npeu.ox.ac.uk/ mbrrace-uk/reports].

7. Artama M, Auvinen A, Raudaskoski T, Isojдrvi I, Isojдrvi J. Antiepileptic drug use of women with epilepsy and congenital malformations in offspring. Neurology 2005; 64:1874–8. https://doi.org/10.1212/01.WNL.0000163771.96962.1F; PMid:15955936

8. Hernбndez-Dнaz S, Smith CR, Shen A, Mittendorf R, 26. Hauser WA, Yerby M, et al.; North American AED Preg- nancy Registry. Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012;78:1692–9. https://doi.org/10.1212/WNL.0b013e3182574f39; PMid:22551726

9. Hernбndez-Dнaz S, Werler MM, Walker AM, Mitchell AA. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med 2000;343:1608–14. https://doi.org/10.1056/NEJM200011303432204; PMid:11096168

10. Mawhinney E, Craig J, Morrow J, Russell A, Smithson WH, Parsons L, et al. Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. Neurology 2013;80:400–5. https://doi.org/10.1212/WNL.0b013e31827f0874; PMid:23303847

11. Meador K, Reynolds MW, Crean S, Fahrbach K, Probst C. Pregnancy outcomes in women with epilepsy: a systematic . review and meta-analysis of published pregnancy registries and cohorts. Epilepsy Res 2008;81:1–13. https://doi.org/10.1016/j.eplepsyres.2008.04.022; PMid:18565732 PMCid:PMC2660205

12. Morrow J, Russell A, Guthrie E, Parsons L, Robertson I, Waddell R, et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2006;77:193–8. https://doi.org/10.1136/jnnp.2005.074203; PMid:16157661 PMCid:PMC2077578

13. Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Sabers A, et al.; EURAP study group. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 2011;10:609–17. https://doi.org/10.1016/S1474-4422(11)70107-7

14. Banach R, Boskovic R, Einarson T, Koren G. Long-term developmental outcome of children of women with 33. epilepsy, unexposed or exposed prenatally to antiepileptic drugs: a meta-analysis of cohort studies. Drug Saf 2010;33: 73–9. https://doi.org/10.2165/11317640-000000000-00000; PMid:20000869

15. Meador KJ, Baker GA, Browning N, Cohen MJ, Bromley RL, Clayton-Smith J, et al.; NEAD Study Group. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. Lancet Neurol 2013;12:244–52. https://doi.org/10.1016/S1474-4422(12)70323-X

16. Confidential Enquiry into Maternal and Child Health. Why Mothers Die 2000–2002. The Sixth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. London: RCOG Press; 2004.

17. Centre for Maternal and Child Enquiries (CMACE). Saving Mothers’ Lives: reviewing maternal deaths to make motherhood safer: 2006–08. The Eighth Report on Confidential Enquiries into Maternal Deaths in the United Kingdom. BJOG 2011;118 Suppl 1:1–203.

18. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia 2014;55:475–82. https://doi.org/10.1111/epi.12550; PMid:24730690

19. Battino D, Tomson T, Bonizzoni E, Craig J, Lindhout D, Sabers A, et al.; EURAP Study Group. Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. Epilepsia 2013;54: 1621–7. https://doi.org/10.1111/epi.12302; PMid:23848605

20. Shorvon S,Tomson T. Sudden unexpected death in epilepsy. Lancet 2011;378:2028–38. https://doi.org/10.1016/S0140-6736(11)60176-1

21. Nashef L. Sudden unexpected death in epilepsy: termi- nology and definitions. Epilepsia 1997;38 Suppl s11:S6–8. https://doi.org/10.1111/j.1528-1157.1997.tb06130.x; PMid:19909329

22. Teramo K, Hiilesmaa V, Bardy A, Saarikoski S. Fetalheartrate during a maternal grand mal epileptic seizure. J Perinat Med 1979;7:3–6. https://doi.org/10.1515/jpme.1979.7.1.3; PMid:106102

23. Chadwick D, Smith D. The misdiagnosis of epilepsy. BMJ 2002;324:495–6. https://doi.org/10.1136/bmj.324.7336.495; PMid:11872532 PMCid:PMC1122430

24. Chowdhury FA, Nashef L, Elwes RD. Misdiagnosis in epilepsy: a review and recognition of diagnostic uncertainty. Eur J Neurol 2008;15:1034–42. https://doi.org/10.1111/j.1468-1331.2008.02260.x; PMid:18717721

25. Edlow JA, Caplan LR, O’Brien K, Tibbles CD. Diagnosis of acute neurological emergencies in pregnant and post-partum women. Lancet Neurol 2013;12:175–85. https://doi.org/10.1016/S1474-4422(13)70022-X; https://doi.org/10.1016/S1474-4422(12)70306-X

26. Enye S, Ganapathy R, Braithwaite O. Proteinuria in status epilepticus or eclampsia; a diagnostic dilemma. Am J Emerg Med 2009;27:625.e5–6. https://doi.org/10.1016/j.ajem.2008.08.020; PMid:19497473

27. Pandey R, Garg R, Darlong V, Punj J, Khanna P. Recurrent seizures in pregnancy-epilepsy or eclampsia: a diagnostic dilemma? A case report. AANA J 2011;79:388–90. PMid:23256267

28. Gaillard WD, Cross JH, Duncan JS, Stefan H,Theodore WH; Task Force on Practice Parameter Imaging Guidelines for the International League Against Epilepsy, Commission for Diagnostics. Epilepsy imaging study guideline criteria: commentary on diagnostic testing study guidelines and practice parameters. Epilepsia 2011;52:1750–6. https://doi.org/10.1111/j.1528-1167.2011.03155.x; PMid:21740417 PMCid:PMC3169743

29. Dineen R, Banks A, Lenthall R. Imaging of acute neurological conditions in pregnancy and the puerperium. Clin Radiol 2005;60:1156–70. https://doi.org/10.1016/j.crad.2005.03.010; PMid:16223612

30. ACOG Committee on Obstetric Practice.ACOG Committee Opinion. Number 299, September 2004 (replaces No. 158, September 1995). Guidelines for diagnostic imaging during pregnancy. Obstet Gynecol 2004;104:647–51. PMid:15339791

31. Altman D, Carroli G, Duley L, Farrell B, Moodley J, Neilson J, et al.; Magpie Trial Collaboration Group. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo- controlled trial. Lancet 2002;359:1877–90. https://doi.org/10.1016/S0140-6736(02)08778-0

32. Beach RL, Kaplan PW. Seizures in pregnancy: diagnosis and management. Int Rev Neurobiol 2008;83:259–71. https://doi.org/10.1016/S0074-7742(08)00015-9

33. Reuber M, Baker GA, Gill R, Smith DF, Chadwick DW. Failure to recognize psychogenic nonepileptic seizures may cause death. Neurology 2004;62:834–5. https://doi.org/10.1212/01.WNL.0000113755.11398.90; PMid:15007151

34. Fairgrieve SD, Jackson M, Jonas P, Walshaw D, White K, Montgomery TL, et al. Population based, prospective study of the care of women with epilepsy in pregnancy. BMJ 2000;321:674–5. https://doi.org/10.1136/bmj.321.7262.674; PMid:10987772 PMCid:PMC27482

35. Helbig KL, Bernhardt BA, Conway LJ,Valverde KD, Helbig I, Sperling MR. Genetic risk perception and reproductive decision making among people with epilepsy. Epilepsia 2010;51:1874–7. https://doi.org/10.1111/j.1528-1167.2009.02507.x; PMid:20163441

36. Shostak S, Ottman R. Ethical, legal, and social dimensions of epilepsy genetics. Epilepsia 2006;47:1595–602. https://doi.org/10.1111/j.1528-1167.2006.00632.x; PMid:17054679 PMCid:PMC1802101

37. Campbell E, Kennedy F, Russell A, Smithson WH, Parsons L, 54. Morrison PJ, et al. Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. J Neurol 55. Neurosurg Psychiatry 2014;85:1029–34. https://doi.org/10.1136/jnnp-2013-306318; PMid:24444855

38. Bromley R, Weston J, Adab N, Greenhalgh J, Sanniti A, McKay AJ, et al. Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. Cochrane Database Syst Rev 2014;(10): CD010236. https://doi.org/10.1002/14651858.cd010236.pub2

39. Bromley RL, Mawer GE, Briggs M, Cheyne C, Clayton- Smith J, Garcнa-Fiсana M, et al.; Liverpool and Manchester Neurodevelopment Group. The prevalence of neuro-developmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 2013;84:637–43. https://doi.org/10.1136/jnnp-2012-304270; PMid:23370617 PMCid:PMC4115188

40. Christensen J, Grшnborg TK, Sшrensen MJ, Schendel D, Parner ET, Pedersen LH, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 2013;309:1696–703. https://doi.org/10.1001/jama.2013.2270; PMid:23613074 PMCid:PMC4511955

41. Shallcross R, Bromley RL, Irwin B, Bonnett LJ, Morrow J, Baker GA; Liverpool Manchester Neurodevelopment Group; UK Epilepsy and Pregnancy Register. Child development following in utero exposure: levetiracetam vs sodium valproate. Neurology 2011;76:383–9. https://doi.org/10.1212/WNL.0b013e3182088297; PMid:21263139 PMCid:PMC3271390

42. Shallcross R, Bromley RL, Cheyne CP, Garcнa-Fiсana M, Irwin B, Morrow J, et al.; Liverpool and Manchester Neurodevelopment Group; UK Epilepsy and Pregnancy Register. In utero exposure to levetiracetam vs valproate: development and language at 3 years of age. Neurology 2014;82:213–21.

43. Morrow JI, Hunt SJ, Russell AJ, Smithson WH, Parsons L, Robertson I, et al. Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 2009;80:506–11. https://doi.org/10.1136/jnnp.2008.156109; PMid:18977812

44. Ogawa Y, Kaneko S, Otani K, Fukushima Y. Serum folic acid levels in epileptic mothers and their relationship to congenital malformations. Epilepsy Res 1991;8:75–8. https://doi.org/10.1016/0920-1211(91)90039-I

45. Kaaja E, Kaaja R, Hiilesmaa V. Major malformations in offspring of women with epilepsy. Neurology 2003;60: 575–9. https://doi.org/10.1212/01.WNL.0000044157.28073.DC; PMid:12601095

46. Betts T, Fox C. Proactive pre-conception counselling for women with epilepsy — is it effective? Seizure 1999;8:322–7. https://doi.org/10.1053/seiz.1999.0325; PMid:10512771

47. Vajda FJ, O’Brien TJ, Hitchcock A, Graham J, Cook M, Lander C, et al. Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy. J Clin Neurosci 2004;11:854–8. https://doi.org/10.1016/j.jocn.2004.05.003; PMid:15519862

48. Vajda FJ, O’Brien TJ, Hitchcock A, Graham J, Lander C.The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months. J Clin Neurosci 2003;10: 543–9. https://doi.org/10.1016/S0967-5868(03)00158-9

49. Vajda FJ, Hitchcock A, Graham J, O’Brien T, Lander C, Eadie M. Seizure control in antiepileptic drug-treated pregnancy. Epilepsia 2008;49:172–6. https://doi.org/10.1111/j.1528-1167.2007.01412.x; PMid:18031551

50. Gjerde IO, Strandjord RE, Ulstein M.The course of epilepsy during pregnancy: a study of 78 cases. Acta Neurol Scand 1988;78:198–205. https://doi.org/10.1111/j.1600-0404.1988.tb03646.x; PMid:3147566

51. Tomson T, Lindbom U, Ekqvist B, Sundqvist A. Epilepsy and pregnancy: a prospective study of seizure control in 72. relation to free and total plasma concentrations of carbamazepine and phenytoin. Epilepsia 1994;35:122–30. https://doi.org/10.1111/j.1528-1157.1994.tb02921.x; PMid:8112234

52. Boardman SG. Understanding the experiences of pregnancy in women with epilepsy [PhD dissertation]. [Hull]: University of Hull; 2013.

53. Williams J, Myson V, Steward S, Jones G, Wilson JF, Kerr MP, et al. Self-discontinuation of antiepileptic medication in pregnancy: detection by hair analysis. Epilepsia 2002;43: 824–31. https://doi.org/10.1046/j.1528-1157.2002.38601.x; PMid:12181000

54. Widnes SF, Schjшtt J, Granas AG. Risk perception and medicines information needs in pregnant women with epilepsy – a qualitative study. Seizure 2012;21:597–602. https://doi.org/10.1016/j.seizure.2012.06.007; PMid:22762859

55. Crawford P, Hudson S. Understanding the information needs of women with epilepsy at different lifestages: results of the ‘Ideal World’ survey. Seizure 2003;12:502–7. https://doi.org/10.1016/S1059-1311(03)00085-2

56. Nadel AS, Green JK, Holmes LB, Frigoletto FD Jr, Benacerraf BR. Absence of need for amniocentesis in patients with elevated levels of maternal serum alpha- fetoprotein and normal ultrasonographic examinations. N Engl J Med 1990;323:557–61. https://doi.org/10.1056/NEJM199008303230901; PMid:1696358

57. Adab N. Therapeutic monitoring of antiepileptic drugs during pregnancy and in the postpartum period: is it useful CNS Drugs 2006;20:791–800. https://doi.org/10.2165/00023210-200620100-00001; PMid:16999450

58. Pennell PB. Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology 2003;61 Suppl 2: S35–42. https://doi.org/10.1212/WNL.61.6_suppl_2.S35; PMid:14504308

59. Pennell PB, Hovinga CA. Antiepileptic drug therapy in pregnancy I: gestation-induced effects on AED pharmacokinetics. Int Rev Neurobiol 2008;83:227–40. https://doi.org/10.1016/S0074-7742(08)00013-5

60. Miљkov S, Gjergja-Juraљki R, Cvitanovi мc-Љojat L, Bakuli мc TI, Fuc ic A, Boљnjak-Paљi мc M, et al. Prospective surveillance of Croatian pregnant women on lamotrigine monotherapy – aspects of pre-pregnancy counseling and drug monitoring. Acta Clin Croat 2009;48:271–81. PMid:20055248

61. Harden CL, Pennell PB, Koppel BS, Hovinga CA, Gidal B, Meador KJ, et al.;American Academy of Neurology;American Epilepsy Society. Practice parameter update: management issues for women with epilepsy—focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding. Neurology 2009;73:142–9. https://doi.org/10.1212/WNL.0b013e3181a6b312; https://doi.org/10.1212/WNL.0b013e3181a6b2f8; https://doi.org/10.1212/WNL.0b013e3181a6b325; PMid:19398680 PMCid:PMC3475193

62. Pirie DA, Al Wattar BH, Pirie AM, Houston V, Siddiqua A, Doug M, et al. Effects of monitoring strategies on seizures in pregnant women on lamotrigine: a meta-analysis. Eur J Obstet Gynecol Reprod Biol 2014;172:26–31. https://doi.org/10.1016/j.ejogrb.2013.10.021; PMid:24211103

63. Perucca P, Gilliam FG.Adverse effects of antiepileptic drugs. Lancet Neurol 2012;11:792–802. https://doi.org/10.1016/S1474-4422(12)70153-9

64. Jackson MJ,Turkington D. Depression and anxiety in epilepsy. J Neurol Neurosurg Psychiatry 2005;76 Suppl 1:i45–7. https://doi.org/10.1136/jnnp.2004.060467; PMid:15718221 PMCid:PMC1765680

65. Park SP, Kwon SH. Cognitive effects of antiepileptic drugs. J Clin Neurol 2008;4:99–106. https://doi.org/10.3988/jcn.2008.4.3.99; PMid:19513311 PMCid:PMC2686875

66. Viale L, Allotey J, Cheong-See F, Arroyo-Manzano D, Mccorry D, Bagary M, et al.; EBM CONNECT Collaboration. Epilepsy in pregnancy and reproductive outcomes: a system- atic review and meta-analysis. Lancet 2015;386:1845–52. https://doi.org/10.1016/S0140-6736(15)00045-8

67. Malow BA. Sleep and epilepsy. Neurol Clin 2005;23: 1127–47. https://doi.org/10.1016/j.ncl.2005.07.002; PMid:16243619

68. Lamberts RJ, Thijs RD, Laffan A, Langan Y, Sander JW. Sudden unexpected death in epilepsy: people with nocturnal seizures may be at highest risk. Epilepsia 2012;53:253–7. https://doi.org/10.1111/j.1528-1167.2011.03360.x; PMid:22192074

69. Hiilesmaa VK, Bardy A, Teramo K. Obstetric outcome in women with epilepsy. Am J Obstet Gynecol 1985;152: 499-504. https://doi.org/10.1016/0002-9378(85)90615-5

70. HiilesmaaVK.Pregnancyandbirthin womenwithepilepsy. Neurology 1992;42(4 Suppl 5):8–11. PMid:1574182

71. Nomura R, Bessa JF, Custуdio MG, Galletta MA, Zugaib M. P24.11: Computerized cardiotocography and Doppler velocimetry in fetuses exposed to antiepileptic drugs [abstract]. Ultrasound Obstet Gynecol 2010;36 Suppl 1:262.

72. Yamasmit W, Chaithongwongwatthana S, Tolosa JE. Prenatal vitamin K1 administration in epileptic women to prevent neonatal hemorrhage: is it effective J Reprod Med 2006;51:463–6. PMid:16846083

73. Choulika S, Grabowski E, Holmes LB. Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants? Am J Obstet Gynecol 2004;190:882–3. https://doi.org/10.1016/j.ajog.2004.01.041; PMid:15118607

74. Kaaja E, Kaaja R, Matila R, Hiilesmaa V. Enzyme-inducing antiepileptic drugs in pregnancy and the risk of bleeding in the neonate. Neurology 2002;58:549–53. https://doi.org/10.1212/WNL.58.4.549; PMid:11865131

75. Smith PE, Saunders J, Dawson A, Kerr MP. Intractable seizures in pregnancy. Lancet 1999;354:1522. https://doi.org/10.1016/S0140-6736(99)09164-3

76. Patsalos PN, Frцscher W, Pisani F, van Rijn CM. The importance of drug interactions in epilepsy therapy. Epilepsia 2002;43:365–85. https://doi.org/10.1046/j.1528-1157.2002.13001.x; PMid:11952767

77. Bardy A. Epilepsy and pregnancy: a prospective study of 154 pregnancies in epileptic women [thesis]. Helsinki, Finland, University of Helsinki; 1982.

78. Pennell PB. EURAP outcomes for seizure control during pregnancy: useful and encouraging data. Epilepsy Curr 2006;6:186–8. https://doi.org/10.1111/j.1535-7511.2006.00140.x; PMid:17260054 PMCid:PMC1783493

79. Nei M, Daly S, Liporace J.A maternal complex partial seizure in labor can affect fetal heart rate. Neurology 1998;51:904–6. https://doi.org/10.1212/WNL.51.3.904; PMid:9748057

80. Schmidt D, Canger R, Avanzini G, Battino D, Cusi C, Beck-Mannagetta G, et al. Change of seizure frequency in pregnant epileptic women. J Neurol Neurosurg Psychiatry 1983;46:751–5. https://doi.org/10.1136/jnnp.46.8.751; PMid:6411866 PMCid:PMC1027530

81. Kevat D, Mackillop L. Neurological diseases in pregnancy. J R Coll Physicians Edinb 2013;43:49–58. https://doi.org/10.4997/JRCPE.2013.112; PMid:23516693

82. EURAP Study Group. Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry. Neurology 2006;66:354–60. https://doi.org/10.1212/01.wnl.0000195888.51845.80; PMid:16382034

83. DeLorenzo RJ, Garnett LK, Towne AR, Waterhouse EJ, Boggs JG, Morton L, et al. Comparison of status epilepticus with prolonged seizure episodes lasting from 10 to 29 minutes. Epilepsia 1999;40:164–9. https://doi.org/10.1111/j.1528-1157.1999.tb02070.x; PMid:9952262

84. Alldredge BK, Gelb AM, Isaacs SM, Corry MD, Allen F, Ulrich S, et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilep- ticus. N Engl J Med 2001;345:631–7. https://doi.org/10.1056/NEJMoa002141; PMid:11547716

85. McElhatton PR.The effects of benzodiazepine use during pregnancy and lactation. Reprod Toxicol 1994;8:461–75. https://doi.org/10.1016/0890-6238(94)90029-9

86. Kuczkowski KM. Labor analgesia for the parturient with neurological disease: what does an obstetrician need to know? Arch Gynecol Obstet 2006;274:41–6. https://doi.org/10.1007/s00404-006-0130-6; https://doi.org/10.1007/s00404-006-0137-z; https://doi.org/10.1007/s00404-006-0125-3; https://doi.org/10.1007/s00404-006-0136-0; https://doi.org/10.1007/s00404-006-0127-1; https://doi.org/10.1007/s00404-006-0126-2

87. Daroff RB, Fenichel GM, Jankovic J, Mazziotta JC. Bradley’s Neurology in Clinical Practice. 6th ed. Philadelphia: Elsevier Saunders; 2012.

88. Marinella MA. Meperidine-induced generalized seizures with normal renal function. South Med J 1997;90:556–8. https://doi.org/10.1097/00007611-199705000-00022; PMid:9160082

89. Kuczkowski KM. Seizures on emergence from sevoflurane anaesthesia for Caesarean section in a healthy parturient. Anaesthesia 2002;57:1234–5. https://doi.org/10.1046/j.1365-2044.2002.02913_34.x

90. Hsieh SW, Lan KM, Luk HN, Jawan B. Postoperative seizures after sevoflurane anesthesia in a neonate. Acta Anaesthesiol Scand 2004;48:663. https://doi.org/10.1111/j.0001-5172.2004.0376b.x; PMid:15101868

91. Kuczkowski KM. Sevoflurane and seizures: dйjа vu. Acta Anaesthesiol Scand 2004;48:1216.

92. Borthen I, Eide MG, Daltveit AK, Gilhus NE. Obstetric outcome in women with epilepsy: a hospital-based, retrospective study. BJOG 2011;118:956–65. https://doi.org/10.1111/j.1471-0528.2011.03004.x; PMid:21557799

93. Thomas SV, Syam U, Devi JS. Predictors of seizures during pregnancy in women with epilepsy. Epilepsia 2012;53: e85–8. https://doi.org/10.1111/j.1528-1167.2012.03439.x; PMid:22429269

94. Tran TA, Leppik IE, Blesi K, Sathanandan ST, Remmel R. Lamotrigine clearance during pregnancy. Neurology 2002;59:251–5. https://doi.org/10.1212/WNL.59.2.251; PMid:12136066

95. de Haan GJ, Edelbroek P, Segers J, Engelsman M, Lindhout D, Dйvilй-Notschaele M, et al. Gestation-induced changes in lamotrigine pharmacokinetics: a monotherapy study. Neurology 2004;63:571–3. https://doi.org/10.1212/01.WNL.0000133213.10244.FD; PMid:15304599

96. Chen L, Liu F, Yoshida S, Kaneko S. Is breast-feeding of infants advisable for epileptic mothers taking antiepileptic drugs? Psychiatry Clin Neurosci 2010;64:460–8. https://doi.org/10.1111/j.1440-1819.2010.02126.x; PMid:20923425

97. Davanzo R, Dal Bo S, Bua J, Copertino M, Zanelli E, Matarazzo L. Antiepileptic drugs and breastfeeding. Ital J Pediatr 2013;39:50. https://doi.org/10.1186/1824-7288-39-50; PMid:23985170 PMCid:PMC3844381

98. Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M, et al.; NEAD Study Group. Effects of breastfeeding in children of women taking antiepileptic drugs. Neurology 2010;75:1954–60. https://doi.org/10.1212/WNL.0b013e3181ffe4a9; PMid:21106960 PMCid:PMC3014232

99. Veiby G, Engelsen BA, Gilhus NE. Early child development and exposure to antiepileptic drugs prenatally and through breastfeeding: a prospective cohort study on children of women with epilepsy. JAMA Neurol 2013;70:1367–74. https://doi.org/10.1001/jamaneurol.2013.4290; PMid:24061295

100. Turner K, Piazzini A, Franza A, Fumarola C, Chifari R, Marconi AM, et al. Postpartum depression in women with epilepsy versus women without epilepsy. Epilepsy Behav 2006;9:293–7. https://doi.org/10.1016/j.yebeh.2006.06.003; PMid:16861045

101. Galanti M, Newport DJ, Pennell PB,Titchner D, Newman M, Knight BT, et al. Postpartum depression in women with epilepsy: influence of antiepileptic drugs in a prospective study. Epilepsy Behav 2009;16:426–30. https://doi.org/10.1016/j.yebeh.2009.07.009; PMid:19854113 PMCid:PMC3589524

102. Zupanc ML. Antiepileptic drugs and hormonal contraceptives in adolescent women with epilepsy. Neurology 2006;66(6 Suppl 3):S37–45. https://doi.org/10.1212/WNL.66.66_suppl_3.S37; PMid:16567741

103. Beghi E, Cornaggia C; RESt-1 Group. Morbidity and accidents in patients with epilepsy: results of a European cohort study. Epilepsia 2002;43:1076–83. https://doi.org/10.1046/j.1528-1157.2002.18701.x; PMid:12199734

104. Coulam CB, Annegers JF. Do anticonvulsants reduce the efficacy of oral contraceptives? Epilepsia 1979;20:519–25. https://doi.org/10.1111/j.1528-1157.1979.tb04834.x; PMid:477641

105. Gaffield ME, Culwell KR, Lee CR. The use of hormonal contraception among women taking anticonvulsant therapy. Contraception 2011;83:16–29. https://doi.org/10.1016/j.contraception.2010.06.013; PMid:21134499

106. Doose DR,Wang SS, Padmanabhan M, Schwabe S, Jacobs D, Bialer M. Effect of topiramate or carbamazepine on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in healthy obese and nonobese female subjects. Epilepsia 2003;44:540–9. https://doi.org/10.1046/j.1528-1157.2003.55602.x; PMid:12681003

107. Faculty of Sexual and Reproductive Healthcare. Faculty of Sexual & Reproductive Healthcare Clinical Guidance: Combined Hormonal Contraception. [London]: FSRH; 2011 (updated 2012).

108. Faculty of Sexual and Reproductive Healthcare. Faculty of Sexual & Reproductive Healthcare Clinical Guidance: Drug Interactions with Hormonal Contraception. [London]: FSRH; 2011 (updated 2012).

109. Stodieck SR, Schwenkhagen AM. Lamotrigine plasma levels and combined monophasic oral contraceptives (COC) or a contraceptive vaginal ring.A prospective evaluation in 30 women [abstract]. Epilepsia 2004;45 Suppl 7:187.

110. Wegner I, Edelbroek PM, Bulk S, Lindhout D. Lamotrigine kinetics within the menstrual cycle, after menopause, and with oral contraceptives. Neurology 2009;73:1388–93. https://doi.org/10.1212/WNL.0b013e3181bd8295; PMid:19858461

111. World Health Organization. Medical eligibility criteria for contraceptive use. 4th ed. [Geneva]: WHO; 2010.

112. Faculty of Sexual and Reproductive Healthcare [http:// www.fsrh.org/]. Accessed 2016 Jan 06.

113. Harrison-Woolrych M,Hill R.Unintended pregnancies with the etonogestrel implant (Implanon): a case series from postmarketing experience in Australia. Contraception 2005;71:306–8. https://doi.org/10.1016/j.contraception.2004.10.005; PMid:15792651

114. Bensouda-Grimaldi L, Jonville-Bйra AP, Beau-Salinas F, Llabres S,Autret-Leca E; le rйseau des centres rйgionaux de pharmacovigilance. [Insertion problems, removal problems, and contraception failures with Implanon®]. Gynecol Obstet Fertil 2005;33:986–90. [Article in French.] https://doi.org/10.1016/j.gyobfe.2005.10.016; PMid:16321557

115. Faculty of Sexual and Reproductive Healthcare Clinical Effectiveness Unit. Antiepileptic Drugs and Contraception. CEU Statement (January 2010). [London]: FSRH; 2010.

116. Epilepsy Action.‘An Ideal World For Women’ [http://www. epilepsy.org.uk/involved/campaigns/women/ideal-world]. Accessed 2016 Jan 6.

117. Driver and Vehicle Licensing Agency. Current medical guidelines: DVLA guidance for professionals – Neurological appendix [https://www.gov.uk/current-medical-guidelines- dvla-guidance-for-professionals-neurological-chapter- appendix]. Accessed 2016 Jan 6.