SOVREMENNAYA PEDIATRIYA.2019.1(97):49-74; doi 10.15574/SP.2019.97.49

Янковский Д. С., Дымент Г. С., Бережной В. В., Китам В. О., Химич Н. В.
Научно—производственная компания «О.Д. Пролисок», г. Киев, Украина

Обзор посвящен изучению вирусного компонента микробиома человека — вирома. Приведены современные данные, касающиеся состава вирома, его формирования в процессе онтогенеза, роли в патогенезе болезней или поддержании гомеостаза. Особое внимание уделено бактериофагам (фагобиому) как доминантному члену вирома. Представлены сведения о влиянии бактериофагов на состояние прокариотного сообщества микробиома, иммунную систему и их потенциальное участие в развитии патологии. Рассмотрены дискуссионные вопросы, касающиеся перспектив использования бактериофаговой терапии в медицине.

Ключевые слова: виром, микробиом, вирусы, бактериофаги, метагеномика, прокариоты, фагобиом, фаговая терапия.

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Статья поступила в редакцию 03.11.2018 г.; принята в печать 08.02.2019 г.