• Роль пробиотиков в формировании микрофлоры у детей, вскармливаемых искусственными смесями*
ru К содержанию Полный текст статьи

Роль пробиотиков в формировании микрофлоры у детей, вскармливаемых искусственными смесями*

SOVREMENNAYA PEDIATRIYA.2017.7(87):71-78

Абатуров А. Е.
ГУ «Днепропетровская медицинская академия МЗ Украины», г. Днепр
* Опубликовано: Здоровье ребенка. — 2017. — №7.

В статье даны современные представления о значении грудного молока в процессе первичного бактериального заселения пищеварительного тракта у детей. Отражены особенности девиации становления микробиоты кишечника при вскармливании детей искусственными смесями и риск возникновения ассоциированных с микробиотой нарушений состояния здоровья у детей. Представлены доказательства профилактического действия бактерий Bifidobacterium animalis subsp. lactis BB12, предупреждающего возникновение острых инфекционных заболеваний респираторного и пищеварительного тракта и аллергических заболеваний.

Ключевые слова: дети, грудное вскармливание, молочные смеси, микробиота, Bifidobacterium animalis subsp. lactis BB-12.

Литература

1. Бережний В.В., Маменко М.Є. (2016). Мікробіота кишечника новонародженої дитини: вплив на стан здоров'я та фізіологічні підходи до корекції порушень. Дитячий лікар. 3(48): 14—20.

2. Бережной В.В., Крамарев С.А., Шунько Е.Е. (2004). Микрофлора человека и роль современных пробиотиков в ее регуляции. Здоровье женщины. 1(17): 134—139.

3. Майданник В.Г. (2013). Клинические рекомендации по применению пробиотиков в педиатрической практике. К: 30.

4. Aagaard K, Ma J, Antony KM, Ganu R, Petrosino J, Versalovic J. (2014, May 21). The placenta harbors a unique microbiome. Sci Transl Med. 6(237): 237ra65. doi 10.1126/scitranslmed.3008599.

5. Arrieta MC, Stiemsma LT, Amenyogbe N et al. (2014, Sep 5). The intestinal microbiome in early life: health and disease. Front Immunol. 5: 427. https://doi.org/10.3389/fimmu.2014.00427.

6. Belkaid Y, Harrison OJ. (2017, Apr 18). Homeostatic Immunity and the Microbiota. Immunity. 46(4): 562—576. https://doi.org/10.1016/j.immuni.2017.04.008.

7. Bezirtzoglou E, Romond C. (1990). Effect of the feeding practices on the establishment of bacterial interactions in the intestine of the newborn delivered by cesarean section. J Perinat Med. 18(2): 139—43. PMid:2366135.

8. Bezirtzoglou E, Tsiotsias A, Welling GW. (2011, Dec). Microbiota profile in feces of breastand formula-fed newborns by using fluorescence in situ hybridization (FISH). Anaerobe. 17(6): 478—82. https://doi.org/10.1016/j.anaerobe.2011.03.009.

9. Chichlowski M, German JB, Lebrilla CB, Mills DA. (2011). The influence of milk oligosaccharides on microbiota of infants: opportunities for formulas. Annu Rev Food Sci Technol. 2: 331—51. https://doi.org/10.1146/annurev-food-022510-133743.

10. Czarnowicki T. Esaki H., Gonzalez J. et al (2015, Oct). Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets. J Allergy Clin Immunol. 136(4): 941—951.e3. https://doi.org/10.1016/j.jaci.2015.05.049.

11. Dahiya DK, Renuka, Puniya M. et al (2017, Apr 4). Gut Microbiota Modulation and Its Relationship with Obesity Using Prebiotic Fibers and Probiotics: A Review. Front Microbiol. 8: 563. https://doi.org/10.3389/fmicb.2017.00563.

12. De Mello VD, Paananen J, Lindstrom J et al. (2017, Apr 11). Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study. Sci Rep. 7: 46337. https://doi.org/10.1038/srep46337.

13. De Morais MB, Mello CS, Carmo-Rodrigues MS et al. (2017, Apr 18). Microbiota, Environment and Diet. J Pediatr Gastroenterol Nutr. https://doi.org/10.1097/MPG.0000000000001605.

14. Dominguez-Bello MG, Costello EK, Contreras M, Magris M, Hidalgo G, Fierer N, Knight R. (2010). Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA. 107; 26: 11971—11975. https://doi.org/10.1073/pnas.1002601107; PMid:20566857 PMCid:PMC2900693

15. Fitzstevens JL, Smith KC, Hagadorn JI et al. (2016, Sep 27). Systematic Review of the Human Milk Microbiota. Nutr Clin Pract. pii: 0884533616670150. PMid:27679525

16. Gensollen T, Iyer SS, Kasper DL, Blumberg RS. (2016, Apr 29). How colonization by microbiota in early life shapes the immune system. Science. 352(6285): 539—44. https://doi.org/10.1126/science.aad9378.

17. Goulet O. (2015, Aug). Potential role of the intestinal microbiota in programming health and disease. Nutr Rev. 73; Suppl 1: 32—40. https://doi.org/10.1093/nutrit/nuv039.

18. Hetzner NM, Razza RA, Malone LM, Brooks-Gunn J. (2009, Nov). Associations among feeding behaviors during infancy and child illness at two years. Matern Child Health J. 13(6): 795—805. https://doi.org/10.1007/s10995-008-0401-x.

19. Iebba V, Aloi M, Civitelli F, Cucchiara S. (2011). Gut microbiota and pediatric disease. Dig Dis. 29(6): 531-9. https://doi.org/10.1159/000332969.

20. Jost T, Lacroix C, Braegger C, Chassard C. (2013, Oct). Assessment of bacterial diversity inbreast milk using culture-dependent and culture-independent approaches. Br J Nutr. 110(7): 1253—62. https://doi.org/10.1017/S0007114513000597.

21. Jungersen M, Wind A, Johansen E et al. (2014, Mar 28). The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(R). Microorganisms. 2(2): 92—110. https://doi.org/10.3390/microorganisms2020092.

22. Khan I, Yasir M, Azhar EI et al. (2014). Implication of gut microbiota in human health. CNS Neurol Disord Drug Targets. 13(8): 1325—33. https://doi.org/10.2174/1871527313666141023153506.

23. Kugelberg E. (2017, Apr 19). Microbiota: Diet can protect against type 1 diabetes. Nat Rev Immunol. https://doi.org/10.1038/nri.2017.40.

24. Lafortuna CL, Tovar AR, Rastelli F et al. (2017, Jun 1). Clinical, functional, behavioural and epigenomic biomarkers of obesity. Front Biosci (Landmark Ed). 22: 1655—1681. https://doi.org/10.2741/4564

25. Laursen MF, Bahl MI, Michaelsen KF, Licht TR. (2017, Mar 6). First Foods and Gut Microbes. Front Microbiol. 8:356. https://doi.org/10.3389/fmicb.2017.00356.

26. Le Huerou-Luron I, Blat S, Boudry G. (2010, Jun). Breastv formula-feeding: impacts on the digestive tract and immediate and long-term health effects. Nutr Res Rev. 23(1): 23—36. https://doi.org/10.1017/S0954422410000065.

27. Li Y, Tian Y, Zhu W et al. (2014, Jul). Cesarean delivery and risk of inflammatory bowel disease: a systematic review and meta-analysis. Scand J Gastroenterol. 49(7): 834—44. https://doi.org/10.3109/00365521.2014.910834.

28. Lindberg M, Soderquist B. (2017, Feb). Atopic dermatitis and gut microbiota. Br J Dermatol. 176(2): 297—298. https://doi.org/10.1111/bjd.15276.

29. Ma N, Tian Y, Wu Y, Ma X. (2017, Feb 16). Contributions of the Interaction between Dietary Protein and Gut Microbiota to Intestinal Health. Curr Protein Pept Sci. https://doi.org/10.2174/1389203718666170216153505.

30. Moldaver D.M., Larche M., Rudulier C.D. An update on lymphocyte subtypes in Asthma and Airway Disease // Chest. 2016 Nov 3. pii: S0012-3692(16)62326-7. doi 10.1016/j.chest.2016.10.038.

31. Morgan XC, Huttenhower C. (2014, May). Meta-omic analytic techniques for studying the intestinal microbiome. Gastroenterology. 146(6): 1437—1448.e1. https://doi.org/10.1053/j.gastro.2014.01.049.

32. Mshvildadze M, Neu J. (2010, Jul). The infant intestinal microbiome: friend or foe? Early Hum Dev. 86; Suppl 1: 67—71. https://doi.org/10.1016/j.earlhumdev.2010.01.018.

33. Mueller NT, Whyatt R, Hoepner L et al. (2015, Apr). Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity. Int J Obes (Lond). 39(4): 665—70. https://doi.org/10.1038/ijo.2014.180.

34. Murphy K, Curley D, O'Callaghan TF et al. (2017, Jan 17). The Composition of Human Milk and Infant Faecal Microbiota Over the First Three Months of Life: A Pilot Study. Sci Rep. 7: 40597. https://doi.org/10.1038/srep40597.

35. Qin J, Li R, Raes J et al. (2010, Mar 4). A human gut microbial gene catalogue established by metagenomic sequencing. MetaHIT Consortium, P. Bork, S.D. Ehrlich, J. Wang. Nature. 464(7285): 59—65. https://doi.org/10.1038/nature08821.

36. Raghunath P. (2017, Feb). Role of Gut Microbiota and Infectious Burden in the Development of Autoimmune and Allergic Diseases. Iran J Allergy Asthma Immunol. 16(1): 77—78. PMid:28417628.

37. Ringel-Kulka T, Kotch JB, Jensen ET et al. (2015, Jun). Randomized, double-blind, placebo-controlled study of synbiotic yogurt effect on the health of children. J Pediatr. 166(6): 1475—81.e1—3. doi 10.1016/j.jpeds.2015.02.038.

38. Ro AD, Simpson MR, Ro TB. (2017, Mar 27). Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternalprobiotic supplementation . Clin Exp Allergy. https://doi.org/10.1111/cea.12930.

39. Rosenfeld CS. (2015, Oct). Microbiome Disturbances and Autism Spectrum Disorders. Drug Metab Dispos. 43(10): 1557—71. https://doi.org/10.1124/dmd.115.063826.

40. Sakwinska O, Moine D, Delley M et al. (2016, Aug 16). Microbiota in Breast Milk of Chinese Lactating Mothers. PLoS One.; 11(8): e0160856. https://doi.org/10.1371/journal.pone.0160856.

41. Simpson MR, Dotterud CK, Storro O et al. (2015, Aug 1). Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial. BMC Dermatol. 15: 13. https://doi.org/10.1186/s12895-015-0030-1.

42. Singanayagam A, Ritchie AI, Johnston SL. (2017, Jan). Role of microbiome in the pathophysiology and disease course of asthma. Curr Opin Pulm Med. 23(1): 41-47. https://doi.org/10.1097/MCP.0000000000000333; PMid:27755161.

43. Souwer Y, Szegedi K, Kapsenberg ML, de Jong EC. (2010, Dec). IL-17 and IL-22 in atopic allergic disease. Curr Opin Immunol. 22(6): 821—6. https://doi.org/10.1016/j.coi.2010.10.013.

44. Stiemsma LT, Turvey SE. (2017, Jan 6). Asthma and the microbiome: defining the critical window in early life. Allergy Asthma Clin Immunol. 13: 3. https://doi.org/10.1186/s13223-016-0173-6.

45. Sundin J, Ohman L, Simren M. (2017, Apr 18). Understanding the Gut Microbiota in Inflammatory and Functional Gastrointestinal Diseases. Psychosom Med. https://doi.org/10.1097/PSY.0000000000000470.

46. Taipale T, Pienihakkinen K, Alanen P et al. (2013). Administration of Bifidobacterium animalis subsp. lactis BB-12in early childhood: a post-trial effect on caries occurrence at four years of age. Caries Res. 47(5): 364—72. https://doi.org/10.1159/000348424.

47. Taipale TJ, Pienihakkinen K, Isolauri E et al. (2016, Jan). Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood. Pediatr Res. 79(1-1): 65—9. doi 10.1038/pr.2015.174.

48. Tlaskalova-Hogenova H, Stepankova R, Kozakova H et al. (2011, Mar). The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-ree and gnotobiotic animal models of human diseases. Cell Mol Immunol. 8(2): 110—20. https://doi.org/10.1038/cmi.2010.67.

49. Tomkovich S, Yang Y, Winglee K et al. (2017, Apr 17). Locoregional effects of microbiota in a preclinical model of colon carcinogenesis. Cancer Res. pii: canres.3472.2016. doi 10.1158/0008-5472.CAN-16-3472.

50. Vaiserman AM, Koliada AK, Marotta F. (2017, May). Gut microbiota: A player in aging and a target for anti-aging intervention. Ageing Res Rev. 35: 36—45. https://doi.org/10.1016/j.arr.2017.01.001.

51. Werfel T, Allam JP, Biedermann T et al. (2016, Aug). Cellular and molecular immunologic mechanisms in patients with atopic dermatitis. J Allergy Clin Immunol. 138(2): 336—49. https://doi.org/10.1016/j.jaci.2016.06.010.

52. West CE. (2014, May). Gut microbiota and allergic disease: new findings. Curr Opin Clin Nutr Metab Care. 17(3):261—6. https://doi.org/10.1097/MCO.0000000000000044.

53. Xu Z, Knight R. (2015, Jan). Dietary effects on human gut microbiome diversity. Br J Nutr. 113; Suppl: S1—5. https://doi.org/10.1017/S0007114514004127.