• Лихорадка неизвестного происхождения у детей
ru К содержанию Полный текст статьи

Лихорадка неизвестного происхождения у детей

SOVREMENNAYA PEDIATRIYA.2019.3(99):44-49; doi 10.15574/SP.2019.99.44

Космынина Н. С.
Львовский национальный медицинский университет имени Данила Галицкого, Украина

В данной статье рассмотрено современное состояние проблемы лихорадки неизвестного происхождения у детей. Представлены основные этапы изучения данного вопроса с описанием механизмов лихорадки, проанализированы причины лихорадки у детей разных стран, представлен дифференциально-диагностический алгоритм ведения больных с лихорадкой неизвестного происхождения и проанализирована диагностическая ценность наиболее значимых лабораторных и инструментальных методов исследования. Показано, что диагностический поиск при наличии лихорадки неизвестного происхождения включает выявление клинико-лабораторных признаков, обуславливающих особенности целенаправленного обследования пациентов по использованию наиболее информативных для конкретной клинической ситуации диагностических методов. Вопрос же о целесообразности назначения лечения до установления причины лихорадки должен решаться врачом строго индивидуально, в зависимости от конкретной клинической ситуации.

Ключевые слова: лихорадка неизвестного происхождения, дети.

ЛИТЕРАТУРА

1. Abdelbaky M, Mansour H, Ibrahim S et al. (2011). Prevalence of connective tissue diseases in egyptian patients presenting with Fever of unknown origin. Clin Med Insights Arthritis Musculoskelet Disord. 4: 33—41. https://doi.org/10.4137/CMAMD.S6763; PMid:21789030 PMCid:PMC3115637

2. Antoon J, Bradford K. (2013). Fever of unknown origin in a child. Clin. Pediatr. (Phila). 52(1): 99—102. https://doi.org/10.1177/0009922812463958; PMid:23117240

3. Antoon J, Peritz D, Parsons M et al. (2018). Etiology and Resource Use of Fever of Unknown Origin in Hospitalized Children. Hosp Pediatr. 8(3): 135. https://doi.org/10.1542/hpeds.2017-0098; PMid:29487087

4. Attard1 L, Tadolini M, De Rose D et al. (2018). Overview of fever of unknown origin in adult and paediatric patients. Clin Exp Rheumatol. 36: 10—24.

5. Barron K, Athreya B, Kastner D. (2011). Periodic fever syndromes and other inherited autoinflammatory diseases. Textbook of Pediatric Rheumatology: 642—660. https://doi.org/10.1016/B978-1-4160-6581-4.10043-3

6. Blokhuis G, Bleeker-Rovers C, Diender M et al. (2014). Diagnostic value of FDG-PET/(CT) in children with fever of unknown origin and unexplained fever during immune suppression. European journal of nuclear medicine and molecular imaging. 41(10): 1916—1923. https://doi.org/10.1007/s00259-014-2801-z; PMid:24869631

7. Carl J, Seashore M, Jacob A et al. (2011). Fever of Unknown Origin in Children Pediatric Annals. 40(1): 26—30. https://doi.org/10.3928/00904481-20101214-07; PMid:21210597

8. Chien Y, Huang F, Huang C et al. (2015). Clinical approach to fever of unknown origin in children. J Microbiol Immunol Infect. 50(6): 893—898. https://doi.org/10.1016/j.jmii.2015.08.007; PMid:27143687

9. Cho C, Lai C, Lee M et al. (2017). Clinical analysis of fever of unknownorigin in children: a 10-year experience in a northern Taiwan medical center. J Microbiol Immunol Infect. 50: 40—42. https://doi.org/10.1016/j.jmii.2015.01.001; PMid:25735796

10. Chow A, Robinson J. (2011). Fever of unknown origin in 185 pediatric patients. Acta Pediatr. 7(1): 5—10. https://doi.org/10.1007/s12519-011-0240-5; PMid:21191771

11. Chow A, Robinson J. (2011). Fever of unknown origin in children: a systematic review. World J. Pediatr. 7(1): 5—10. https://doi.org/10.1007/s12519-011-0240-5; PMid:21191771

12. Chusid M. (2017). Fever of Unknown Origin in Childhood. Pediatr Clin North Am. 64: 205—30. https://doi.org/10.1016/j.pcl.2016.08.014; PMid:27894446

13. Costanzo M, Camarca M, Colella M et al. (2011). Acute disseminated encephalomyelitis presenting as fever of unknown origin: case report. BMC Pediatrics. 11: 103 https://doi.org/10.1186/1471-2431-11-103; PMid:22074226 PMCid:PMC3228665

14. Cunha B, Hage J, Nouri Y. (2012). Recurrent fever of unknown origin (FUO): aseptic meningitis, hepatosplenomegaly, pericarditis and a double quotidian fever due to juvenile rheumatoid arthritis (JRA). Heart Lung. 41(2): 177—80. https://doi.org/10.1016/j.hrtlng.2008.01.003; PMid:18992633

15. Cunha B, Lortholary O, Cunha C. (2015). Fever of unknown origin: a clinical approach. Am J Med. 128(10): 1138.e1-1138.e15. https://doi.org/10.1016/j.amjmed.2015.06.001; PMid:26093175.

16. Dayal R, Agarwal D. (2016). Fever in children and fever of unknown origin. Indian J Pediatr. 83(1): 38—43. https://doi.org/10.1007/s12098-015-1724-4; PMid:25724501

17. Gattorno M, Caorsi R, Meini A et al. (2009). Differentiating PFAPA syndrome from monogenic periodic fevers. Pediatrics. 124(4): e721-8. https://doi.org/10.1542/peds.2009-0088; PMid:19786432

18. Gundeslioglu O, Kocabas E, Emre Alhan1 E et al. (2019). Fever of unknown origin: evaluation of 30 pediatric patients. Cukurova Medical Journal. 44(1): 215—220. https://doi.org/10.17826/cumj.470285

19. Hassan R, Fouda A, Kandil S. (2014). Fever of unknown origin in children: a 6-year experience in a tertiary pediatric Egyptian hospital. Int J Health Sci (Qassim). 8: 13—19. https://doi.org/10.12816/0006067

20. Horowitz H. (2013). Fever of unknown origin or fever of too many origins? Engl J Med. 368(3): 197—199. https://doi.org/10.1056/NEJMp1212725; PMid:23323894

21. James W, Antoon J, Nicolas M et al. (2015). Pediatric of Unknown Origin. J Pediatr. 36: 380—391. https://doi.org/10.1542/pir.36-9-380; PMid:26330472

22. Kim S, Kim U, Jang M et al. (2013). Diagnostic use of serum ferritin levels to differentiate infectious and noninfectious diseases in patients with fever of unknown origin. Dis Markers. 34(3): 211—218. https://doi.org/10.1155/2013/915389

23. Mahmoudi S, Mehrazmay A, Salesi M et al. (2014). Fever of unknown origin: a retrospective study of 95 children in an Iranian referral hospital. Br J Biomed Sci. 71(1): 40—42. https://doi.org/10.1080/09674845.2014.11669961; PMid:24693574

24. Marshall G. (2014). Prolonged and recurrent fevers in children. J Infect. 68;1: 83—93. https://doi.org/10.1016/j.jinf.2013.09.017; PMid:24120354.

25. McGregor A, Moore D. (2015). Infectious causes of fever of unknown origin. Clin Med (Lond). 15(3): 285—7. https://doi.org/10.7861/clinmedicine.15-3-285; PMid:26031981 PMCid:PMC4953115

26. Naito T, Mizooka M, Mitsumoto F et al. (2013). Diagnostic workup for fever of unknown origin: a multicenter collaborative retrospective study. BMJ Open. 3(12): e003971. https://doi.org/10.1136/bmjopen-2013-003971; PMid:24362014 PMCid:PMC3884594

27. Niehues T. (2013). The febrile child: diagnosis and treatment. Dtsch Arztebl Int. 110(45): 764-73. https://doi.org/10.3238/arztebl.2013.0764; PMid:24290365 PMCid:PMC3849992

28. Niven D, Gaudet J, Laupland K et al. (2015). Accuracy of peripheral thermometers for estimating temperature: a systematic review and meta-analysis. Ann Intern Med. 163: 768—77. https://doi.org/10.7326/M15-1150; PMid:26571241

29. Polsdorfer R, Carson-DeWitt R. (2015, January). Fever of unknown origin. Salem Press Encyclopedia of Health. Serial on the Internet. Research Starters.

30. Rigante D, Esposito S. (2013). A roadmap for fever of unknown origin in children. Int J Immunopathol Pharmacol. 26(2): 315—326. https://doi.org/10.1177/039463201302600205; PMid:23755747

31. Sandoval C, Pinochet C, Pena A et al. (2014). Fever of unknown origin: a challenge for the pediatric infectious diseases specialist. Rev Chilena Infectol. 31(1): 87—91. https://doi.org/10.4067/S0716-10182014000100013; PMid:24740780

32. Seashore C, Lohr J. (2011). Fever of unknown origin in children. Pediatr Ann. 40(1): 26—30. https://doi.org/10.3928/00904481-20101214-07; PMid:21210597

33. Sherman J, Sood S. (2012). Current challenges in the diagnosis and management of fever. Curr Opin Pediatr. 24(3): 400—6. https://doi.org/10.1097/MOP.0b013e32835333e3; PMid:22525720

34. Solimani G, Shafigji S, Salari Z et al. (2015). Fever of unknown origin in children aged three months to fifteen years. Int J Infect. 2(1): e22906. https://doi.org/10.17795/iji-22906

35. Statler V, Marshall G. (2016). Characteristics of Patients Referred to a Pediatric Infectious Diseases Clinic With Unexplained Fever. J Pediatric Infect Dis Soc. 5: 249—56. https://doi.org/10.1093/jpids/piv008; PMid:26407248.

36. Tezer H, Ceyhan M, Kara A et al. (2012). Fever of unknown origin in children: the experience of one center in Turkey. Turk J Pediatr. 54(6): 583—589.

37. Tolan R. (2010). Fever of unknown origin: a diagnostic approach to this vexing problem. Clin Pediatr (Phila). 49: 207—213. https://doi.org/10.1177/0009922809347799; PMid:20164070.

38. Torreggiani S, Filocamo G, Esposito S. (2016). Recurrent Fever in Children. Int J Mol Sci. 17(4): 448. https://doi.org/10.3390/ijms17040448; PMid:27023528 PMCid:PMC4848904

39. Tsai K, Chang H, Chien S et al. (2013). Childhood tuberculosis: epidemiology, diagnosis, treatment, and vaccination. Pediatr Neonatol. 54: 295—302. https://doi.org/10.1016/j.pedneo.2013.01.019; PMid:23597517

40. Vigo G, Zulian F. (2012). Periodic fevers with aphthous stomatitis, pharyngitis, and adenitis (PFAPA). Autoimmun Rev. 12(1): 52—5. https://doi.org/10.1016/j.autrev.2012.07.021; PMid:22878272

41. Wing R, Dor M, McQuilkin P. (2013). Fever in the pediatric patient. Emerg Med Clin North Am. 31: 1073—96. https://doi.org/10.1016/j.emc.2013.07.006

42. Xu L, Zhu Y, Ren L et al. (2017). Characterization of the nasopharyngeal viral microbiome from children with community-acquired pneumonia but negative for Luminex xTAG respiratory viral panel assay detection. Journal of Medical Virology. https://doi.org/10.1002/jmv.24895

43. Ya-Li C, Fang-Liang H, Chung-Ming H. (2017). Clinical approach to fever of unknown origin in children. J Microbiol Immunol Infect. 50(6): 893—898. https://doi.org/10.1016/j.jmii.2015.08.007; PMid:27143687

44. Yo C, Hsieh P, Lee S et al. (2012). Comparison of the test characteristics of procalcitonin to C-reactive protein and leukocytosis for the detection of serious bacterial infections in children presenting with fever without source: a systematic review and meta-analysis. Ann Emerg Med. 60(5): 591—600. https://doi.org/10.1016/j.annemergmed.2012.05.027; PMid:22921165

Статья поступила в редакцию 20.12.2018 г.; принята в печать 15.04.2019 г.