HEALTH OF WOMAN. 2017.1(117):19–24; doi 10.15574/HW.2017.117.19

Grishchenko O. V., Bobrytska V. V.
Kharkiv medical Academy of postgraduate education

The objective: To evaluate the clinical efficacy and safety of Enoxaparin-Pharmex for the prevention of thrombotic complications (pulmonary embolism) in the postoperative period in patients with moderate risk of these complications.

Patients and methods. The study included 50 women after a caesarean section had an average degree of risk of pulmonary embolism. Patients were divided into the main group (n=25) and control group (n=25) in accordance with the treatment: patients of the main group received postoperative Еnoxaparin- Pharmex, group comparisons enoxaparin sodium (brand foreign manufacturer’s). Patients in both groups received the drug at a dose of 20 mg for 5 days, 1 time per day subcutaneously.

Results. The research data analysis showed identity results of hemostasiogram of patients in the main group and the comparison group, no side effects after treatment in both groups.

Conclusion. The clinical studies suggest the drug Enoxaparin-Pharmex is effective, safe LMWH, which can be used to prevent troboembolic complications, including post-operative treatment in obstetric practice. Spectrum of Enoxaparin-Pharmex can be extended to the prevention and treatment of thromboembolic conditions of varying severity with appropriate doses of the drug.

Key words: Enoxaparin-Pharmex, prevention of pulmonary embolism.

REFERENCES
1. Grischenko OV, Korovay SV. 2011. Tromboemboliya legochnoy arterii v akusherskoy praktike. Novosti meditsinyi i farmatsii. Akusherstvo, ginekologiya i reproduktologiya 381: 23–25.
2. Yabluchanskiy NI. Enoksaparin: sozdan dlya lecheniya kriticheskih sostoyaniy. Meditsinskaya gazeta «Medicus Amicus» 2:3.
3. Cavin IA, Lubnini AYu, Gorshkov KM, Popugaev KA, Goryachev AS. 2011. Tyazhelyie tromboticheskie oslozhneniya v posleoperatsionnom periode u rebenka posle udaleniya kraniofaringeomyi. Anesteziologiya i Reanimatologiya 1:62–66.
4. Korzh NA, Filippenko VA, Leonteva FS, Podgayskaya OA. 2012. Enoksaparin v profilaktike tromboembolicheskih oslozhneniy pri endoprotezirovanii sustavov. Novosti meditsinyi i farmatsii 4(402):16–17.
5. Milagros Cruz, Ana M. Fernбndez-Alonso, Isabel Rodrнguez et al. 2012. Prevention of thrombotic complications after cesarean section using two different regimens bemiparin. Medical Council. 2.
6. Blondon M, Casini A, Hoppe KK et al. 2016. Risks of venous thromboembolism after cesarean sections: a meta-analysis. Chest. 150(3):572. https://doi.org/10.1016/j.chest.2016.05.021
7. Elsevier. Cesarean section carries increased risk for postpartum venous thromboembolism (VTE). ScienceDaily, Sep. 22 (2016) http: //www. sciencedaily. com/ releases/ 2016/ 09/ 160922124001. Htm