SOVREMENNAYA PEDIATRIYA.2014.3(59):83-88; doi 10.15574/SP.2014.59.83

Characteristic of the clinical course of allergic diseases in children with vitamin D administrating in complex therapy.

Tyazhka O. V., Selska Z. V

Bohomolets' National Medical University, Kyiv City, Ukraine

Purpose. Assess the clinical course of allergic diseases in children in the use of vitamin D in them.

Materials and methods.We observed 53 patients were children with allergic diseases — asthma, atopic dermatitis and allergic rhinitis. All children surveyed was determined 25(OH)D in serum. Among all the patients were children who received one course of vitamin D and patients who are vitamin D was administered in two treatments, then these patients was determined 25(OH)D in serum and the control group was children with allergic diseases which vitamin D not used. Definition hidroksykaltsyferolu performed using електрохемілюмінісцентного method. Assessing vitamin D was carried out according to the classification of MF Holick et al. (2011.) 

Results. All 53 children (100% ), which was determined by the level of vitamin D in blood serum were determined deficiency of 25(OH)D, the average was 22.54 nmol/l. Treatment of vitamin D performed in 31 children, patients received 2000 IU of watersoluble vitamin D3 daily for 2 — oh months. After ingestion of vitamin D average rate of the vitamin in the serum was 36.54 nmol/l. Despite the insufficient level of 25(OH)D in serum, all children of vitamin D in the treatment of allergic diseases has been suspended in connection with the spring-summer period. The 19 children who were reported after the summer deficiency of vitamin D, cholecalciferol was appointed in high doses. Children receiving vitamin D dose of 4000 IU during remission and exacerbation of the disease and start to completion was 5000 IU dose, the treatment lasted for 2 months. After receiving vitamin D average 25 (OH)D levels was 44.08 nmol/l. Although children with allergies who used vitamin E, failed to reach normal values 25(OH)D in serum was noted improvement in their general condition and for the use of vitamin D in children allergic disease course was easier than the purpose of this vitamin in the treatment . In children (22 children) that vitamin D is not used , the improvement of general

condition were observed, and the course of the underlying disease remained unchanged.

Conclusions. Thus, the use of vitamin D in the treatment of asthma, atopic dermatitis and allergic rhinitis in children makes it easier course of illness they have and improve their general condition. Presumably, vitamin D may one means of prevention and treatment of allergic diseases in children and is administered in the treatment for these patients.

Keywods. children, allergic disease , vitamin D , clinical treatment.

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