Maya–Barrios A.¹, Lira–Hernandez K.², Jimenez–Escobar I.¹, Hernandez L.¹, Ortiz–Hernandez A.³, Jimenez–Gutierrez C.¹, Lopez–Velazquez G.⁴ and Gutierrez–Castrellon P.^2,5

¹Paediatric's Division, Hospital GEA, Calzada de Tlalpan 4800, 14080 Mexico City, Mexico
²Centre for Translational Research on Mother and Child Health, Hospital GEA, Calzada de Tlalpan 4800, 14080, Mexico City, Mexico
³Emergency Department, Instituto Nacional de Pediatria, Insurgentes sur 3700-C, 04530 Mexico City, Mexico
⁴Grupo de Investigacion en Biomoleculas y Salud Infantil, Lab. EIMyT, Instituto Nacional de Pediatria, Insurgentes sur 3700$C, 04530 Mexico City, Mexico
⁵Sociedad Latino Americana de Gastroenterologia, Hepatologia y Nutricion Pediitrica (LASPGHAN) & International Scientific Council for Probiotics, Tenango 22, 14340, Mexico City, Mexico; programacionmetabolica@gmail.com

*Перевод. Оригинал статьи на английском языке опубликован Beneficial Microbes, 2021; 12(2): 137-145. doi 10.3920/BM2020.0171.
Опубликовано: Beneficial Microbes, 2021; 12(2): 137–145. OPEN ACCESS. ISSN 1876-2883 print, ISSN 1876-2891 online, doi 10.3920/BM2020.0171
Оригинальное исследование
Поступила: 10.09.2020. Принята к печати: 19.12.2020
© 2021 Wageningen Academic Publishers

Фарингит и тонзиллит — наиболее распространенные острые респираторные инфекции (ОРИ) у детей в возрасте <5 лет. Анализ опубликованных данных показал, что некоторые пробиотики могут сократить частоту и продолжительность ОРИ. В этом исследовании оценены безопасность и эффективность Limosilactobacillus reuteri (L. reuteri) ATCC PTA 5289 и DSM 17938 для сокращения длительности и тяжести симптомов ОРИ. Это рандомизированное контролированное исследование включало детей в возрасте от 6 месяцев до 5 лет с фарингитом или тонзиллитом. Исследуемые были рандомизированы и получали пробиотический продукт, содержащий L. reuteri ATCC PTA 5289 и L. reuteri DSM 17938 (БиоГая Продентис), или плацебо в виде капель, которые применялись перорально в течение 10 суток в качестве адъювантов до приема нестероидных противовоспалительных препаратов. Основные результаты указывают на связь с продолжительностью и тяжестью симптомов ОРИ. Среди вторичных последствий были выявлены изменения иммуноглобулина А слюны и воспалительных биомаркеров. На 2-е сутки заболевания и в течение последующих суток в группе L. reuteri не было лихорадки (37,3±0,5°C против 38,6±0,3°C, P<0,05). Начиная с 3-их суток сила боли в горле (5±0,9 против 8±1,2, P<0,05) была ниже в группе L. reuteri. Значительные отличия наблюдались в группе L. reuteri, в частности: по количеству суток с насморком, заложенностью носа, суток незапланированных визитов в медицинское учреждение или отделение неотложной помощи, по уровню фактора некроза опухоли альфа (ФНО-α), а также связанных с этим затрат на лечение. Частота побочных эффектов была одинаковой в обеих группах. Таким образом, L. reuteri ATCC PTA 5289 в соединении с L. reuteri DSM 17938 (БиоГая Продентис) является безопасным и эффективным вспомогательным средством для облегчения симптомов фарингита или тонзиллита у детей.
Ключевые слова: L. reuteri, респираторные инфекции, педиатрия.

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