HEALTH OF WOMAN. 2018.7(133):77–83; doi 10.15574/HW.2018.133.77

Яковенко Л. Ф., Ромащенко О. В., Крупская И. В.
Институт молекулярной биологии и генетики НАН Украины, г. Киев
Инстититут урологии АМН Украины, г. Киев

Белки теплового шока (Heat shock proteins – HSPs) – Висококонсервативные белки, которые в увеличенном количестве синтезируются прокариотическими и эукариотическими клетками в условиях стресса. HSPs являются иммунодоминантными антигенами бактерий, распознаются иммунной системой и вызывают развитие реакций клеточного и гуморального иммунитета. Их уровень возрастает в местах острого и хронического воспаления, они вовлечены в патогенез практически всех заболеваний.

Обзор посвящен оценке диагностического потенциала HSPs и анти-HSPs-антител для определения состояния репродуктивной функции у женщин по данным литературы и результатам собственных исследований. Также рассматриваются возможные механизмы вовлечения HSPs и анти-HSPs-антител в развитие трубного бесплодия, ранней недостаточности яичников, процесса потери беременности на ранних терминах.

Ключевые слова: белки теплового шока, антитела к белкам теплового шока, бесплодие, невынашивание беременности, вспомогательные репродуктивные технологии.

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