HEALTH OF WOMAN. 2017.4(120):47–52; doi 10.15574/HW.2017.120.47

Цубанова Н. А., Барская А. В., Губченко Т. Д.
Национальный фармацевтический университет, г. Харьков

В статье приведены современные аспекты этиопатогенетических факторов гиперпластических процессов эндометрия. Проанализированы современные данные по классификации, диагностике и терапии гиперплазии эндометрия. Теоретически обоснована возможность применения в терапии гиперпластических процессов эндометрия современных натуропатических препаратов Нормоменс на основе экстрактов Vitex agnus castus, Zingiber officinale, Trigonella foenum graecum, Pyrus malus и Нормоцикл, содержащего экстракты Symplocos racemosa, Asparagus racemosus, Glycyrrhiza glabra, Curcuma longa.

Ключевые слова: гиперпластические процессы эндометрия, Нормоменс, Нормоцикл.

Литература:
1. Гинекология: национальное руководство/ под. ред. В.И. Кулакова, И.Б. Манухина, Г.М. Савельевой. – М. ГЭОТАР-Медиа, 2007. – С. 761–783.

2. Значение прутняка обыкновенного в гинекологической эндокринологии // Здоров’я України. – 2012. – № 9. – С. 3–4.

3. Киселев В.И., Сидорова И.С., Унанян А.Л., Муйжнек Е.Л. Гиперпластические процессы органов женской репродуктивной системы. – М.: МЕДПРАКТИКА-М, 2010. – С. 467.

4. Кузнецова И.В. Возможности терапии гиперпластических процессов эндометрия / Кузнецова И.В. // Трудный пациент. – 2010. – № 1. – С. 12–16.

5. Потапов В.А. Нормоменс – оптимальная натуропатическая рецептура лечения предменструального синдрома / В.А. Потапов // Здоровье женщины. – 2014. – № 6. – С. 137–142.

6. A comprehensive analysis on Symplocos racemosa Roxb.: Traditional uses, botany, phytochemistry and pharmacological activities / Acharya N, Acharya S, Shah U et al // J Ethnopharmacol. – 2016. – Vol. 181. – P. 236–251. https://doi.org/10.1016/j.jep.2016.01.043; PMid:26851499

7. Absolute risk of endometrial carcinoma during 20-year follow-up among women with endometrial hyperplasia / J.V. Lacey, M.E. Sherman, B.B. Rush et al. // J Clin Oncol. – 2010. – Vol. 28. – P. 788–792. https://doi.org/10.1200/JCO.2009.24.1315; PMid:20065186 PMCid:PMC2834395

8. Abu Hashim H. Levonorgestrelreleasing intrauterine system vs oral progestins for non-atypical endometrial hyperplasia: a systematic review and metaanalysis of randomized trials/ Abu Hashim H, Ghayaty E, El Rakhawy M. // Am J Obstet Gynecol. – 2015. – Vol. 213. – Р. 469–478. https://doi.org/10.1016/j.ajog.2015.03.037; PMid:25797236

9. Adjuvant effect of Asparagus racemosus Willd. derived saponins in antibody production, allergic response and pro-inflammatory cytokine modulation / Tiwari N, Gupta VK, Pandey P, et al.// Biomed Pharmacother. – 2017. – Vol. 86. – Р. 555–561. https://doi.org/10.1016/j.biopha.2016.11.087; PMid:28024292

10. Anti-inflammatory activity of liposomes of Asparagus racemosus root extracts prepared by various methods / Plangsombat N, Rungsardthong K, Kongkaneramit L. et al.// Exp Ther Med. – 2016. – Vol. 12 (4). – Р. 2790–2796. https://doi.org/10.3892/etm.2016.3661

11. Antidiabetic and histopathological analysis of fenugreek extract on alloxan induced diabetic rats / Ramesh B.K., Raghavendra H.L., Kantikar S.M., et al. //International Journal of Drug Development and Research. – 2010. – Vol. 2 (2). – P. 356–364.

12. Comparison of the efficacy of three progestins in the treatment of simple endometrial hyperplasia without atypia / Ozdegirmenci O, Kayikcioglu F, Bozkurt U, et al //Gynecol Obstet Invest. – 2011. – Vol. 72. – P. 10–14. https://doi.org/10.1159/000321390; PMid:21266792

13. Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells / Raju J., Patlolla M.R., Swamy M.V., et al. // Cancer Epidemiology Biomarkers and Prevention. – 2004 – Vol. 13 (8). – P. 1392–1398. PMid:15298963

14. Durkar A.M. Hypolipidemic and antioxidant activity of ethanolic extract of Symplocos racemosa Roxb. in hyperlipidemic rats: an evidence of participation of oxidative stress in hyperlipidemia / Durkar AM, Patil RR, Naik SR. // Indian J Exp Biol. – 2014. – Vol. 52 (1). – Р. 36–45. PMid:24617014

15. Flavonoids from Symplocos racemosa / Jung M, Choi J, Chae S et al // Molecules. – 2014. – Vol. 20 (1). – 358–365. https://doi.org/10.3390/molecules20010358; PMid:25549060

16. Gallos I.D. Prediction of regression and relapse of endometrial hyperplasia with conservative therapy / Gallos ID, Ganesan R, Gupta JK. // Obstet Gynecol. – 2013. – Vol. 121. – Р. 1165–1171. https://doi.org/10.1097/AOG.0b013e31828cb563; PMid:23812448

17. Goyal S. Investigating Therapeutic Potential of Trigonella foenum-graecum L. as Our Defense Mechanism against Several Human Diseases / S. Goyal, N. Gupta, S. Chatterjee // J Toxicol. – 2016. – Vol. 1. – P. 236–248.

18. Immunoaffinity knockout of saponin glycosides from Asparagus racemosus to assess anti-lipid peroxidation / Onlom C, Phrompittayarat W, Putalun W, et al // Phytochem Anal. – 2017. – Vol. 15. – P. 267–268. https://doi.org/10.1002/pca.2678

19. In vitro studies on antiradical and antioxidant activity of (Trigonella foenum graecum) fenugreek seeds / Kaviarasan S., Naik G.H., Gangabhagirathi R. et al. //Food Chemistry. 2007. – Vol. 103. – P. 31–37. https://doi.org/10.1016/j.foodchem.2006.05.064

20. Levonorgestrel-releasing intrauterine system (LNG-IUS) as an effective treatment option for endometrial hyper plasia: a 15-year follow-up study / Scarselli G, Bargelli G, Taddei GL, et al. // Fertil Steril. – 2011. – Vol. 95. – Р. 420–422. https://doi.org/10.1016/j.fertnstert.2010.07.1044; PMid:20723889

21. Management of Endometrial Hyperplasia / Green-top Guideline RCOG BSOG Joint Guideline. – 2016. – Febr. – 30 p.

22. Nonoperative management of atypical endometrial hyperplasia and grade 1 endometrial cancer with the levonorgestrel intrauterine device in medically ill post-menopausal women / Baker WD, Pierce SR, Mills AM et al. // Gynecol Oncol. – 2017. – Vol. 18. – Р. 82–85. https://doi.org/10.1016/j.ygyno.2017.04.006

23. Referring survivors of endometrial cancer and complex atypical hyperplasia to bariatric specialists: a prospective cohort study / Jernigan AM, Maurer KA, Cooper K, et al. //Am J Obstet Gynecol – 2015; Vol. 213 (350). – P. 1–10. https://doi.org/10.1016/j.ajog.2015.05.015

24. Relapse of endometrial hyperplasia after conservative treatment: a cohort study with long-term follow-up / Gallos ID, Krishan P, Shehmar M, et al. // Hum Reprod. – 2013. – Vol. 28. – Р. 1231–1236. https://doi.org/10.1093/humrep/det320; https://doi.org/10.1093/humrep/det049; PMid:23466671

25. Singh R. Asparagus racemosus: a review on its phytochemical and therapeutic potential / Singh R. // Nat Prod Res. – 2016. – Vol. 30 (17). – Р. 1896–1908. https://doi.org/10.1080/14786419.2015.1092148; PMid:26463825