- Vaginal gel Lactagel in correction of vaginal biocenosis in patients after gynecological operations
Vaginal gel Lactagel in correction of vaginal biocenosis in patients after gynecological operations
HEALTH OF WOMAN. 2017.7(123):116–118; doi 10.15574/HW.2017.123.116
Bulavenko O. V., Rud V. O., Bosui S. A.
Vinnitsa national medical University M. I. Pirogov
The objective: to evaluate the clinical efficacy of using Lactagel for the correction of vaginal biocenosis in patients after gynecological operations.
Patients and methods: 50 women of reproductive age with a violation of biocenosis of the vagina, which occurred after gynecological operations, participated in the study. We evaluated the clinical efficacy of the treatment after its conducting using the microbiological and clinical criteria of effectiveness: 1) the dynamics of the subjective signs of bacterial vaginosis on the visual-analog scale in the first day after the operation and before discharge; 2) reduction of the number of objective clinical criteria of Amsel; 3) the dynamics of vaginal biopsy. We use vaginal gel Lactagel according to the scheme: 5 ml intravaginally one time per day for 7 days for the treatment.
Results: The numerical values of the visual analog scale showed that after treatment with Lactagel in 64% of the patients the selection was absent or not significant; the smell of secretions was absent in all patients; moderate itching and burning were absent in all patients. Before the discharge, According to Amsel criteria, the vaginal discharge was determined in eight women (16%); PHі4.5 – in three (6%); a positive KOH test is two (4%), «key» cells in two women (4%). The median concentration of Lactobacillus spp. 105-107 CFU/ml, while Gardenella vaginalis and Atopobium vaginae reached <104 CFU/ml after the treatment.
Conclusion: According to the analysis of the severity of clinical manifestations on the visual-analog scale; The number of objective clinical criteria of the Amelia, the dynamics of vaginal biopsy, we can recommend Laktagel for widespread use in clinical practice.
Key words: vaginal biocenosis, postoperative period, dysbiosis, bacterial vaginosis, lactobacilli, Lactagel.
1. Adaskevich VP. 2006. Infektsii, peredavaemyie polovyim putem. M, Meditsinskaya kniga:425.
2. Budanov PV, Strizhakov AN. 2007. Sostoyanie mikrotsenoza vlagalischa i sposobyi korrektsii ego narusheniy vo vremya beremennosti. Vopr. ginek., akush. i perinat. 6(5):89.
3. Dushkina EA, Kira EF, Badikova NV. 2012. Kislotosoderzhaschie preparatyi v ginekologicheskoy praktike. Effektiv. farmakoterapiya 2:24–28.
4. Kostin IN, Kuvankina LYu, Simonovskaya HYu. 2013. Mikrobiom cheloveka: nash vtoroy genom. Status Praesens. 11:9–15.
5. Kulakov VI, Saveleva GM, Manuhin IB. 2009. Ginekologiya – natsionalnoe rukovodstvo. M.
6. Andersch B, Brandberg A, Holst E. 1990. Treatment of bacterial vaginosis – an acid gel as an alternative to antibiotic treatment. Lakartidningen. 87;7:465–468. PMid:2308407
7. Cauci S. 2004. Vaginal immunity in bacterial vaginosis. Curr. Infect. Dis Rep. 6:450–456. https://doi.org/10.1007/s11908-004-0064-8; PMid:15538982
8. Mendling W, Mailand F. 2002. Microbiological and pharmaco-toxicological profile of nifuratel and its favourable risk/ benefit ratio for the treatment of vulvo-vaginal infections. A review. Arzneimittelforschung. 52;1:8–13. PMid:11838277
9. Sherrard J, Donders G, White D. 2011. European (IUSTI/WHO) Guideline on the Management of Vaginal Discharge 1. Aetiology and transmission.