• Usage of the praparation «Laktiale Baby Formula» for intestinal dysbiosis correction in infants 
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Usage of the praparation «Laktiale Baby Formula» for intestinal dysbiosis correction in infants 

SOVREMENNAYA PEDIATRIYA.2015.7(71):100-106; doi 10.15574/SP.2015.71.100 
 

Usage of the praparation «Laktiale Baby Formula» for intestinal dysbiosis correction in infants 
 

Marushko R. V., Marushko T. L.

SI «Institute of pediatrics, obstetrics and gynecology of the National Academy of Medical Sciences of Ukraine», Kiev 
 

Disorders of the intestinal microbiota is currently one of the most common pathological conditions, especially in infants, which arises under the influence of various unfavorable factors, accompanying various diseases and characterized by changes in the composition of normal microflora. The article presents literature data, reflecting the role of the intestinal microbiota in the maintenance of homeostasis, ensuring the normal physiological function of the bowel, digestion and metabolism. Highlights the problems of disorders in the composition and functions of the intestinal microbiota in various diseases of the gastrointestinal tract and, substantiate the importance of using pro- and prebiotic preparations in the correction of microbiocenosis in bowel diseases. The literature data and the results of own studies on the effectiveness of the drug «Laktiale Baby Formula», which refers to a group of multicomponent probiotics in combination with fructooligosaccharides (prebiotic), allow to recommend it for wide use in pediatric patients for the correction of intestinal dysbiosis in children of first year old, including babies from the age of three months. 
 

Key words: intestinal microbiota, intestinal dysbiosis, probiotic, prebiotic, Laktiale Baby Formula. 
 

REFERENCES

1. Лукьянова ЕМ, Антипкин ЮГ, Янковский ДС и др. 2009. Микробная экологическая система человека и использование отечественных мультипробиотиков для профилактики и устранения ее у детей. Совр педиатрия. 4(26): 117—127

2. Eckburg PB, Bik EM, Bernstein CN et al. 2005. Diversity of the Human Intestinal Microbial Flora. Science. 308: 1635—1639. http://dx.doi.org/10.1126/science.1110591; PMid:15831718 PMCid:PMC1395357

3. Guandalini S, Cernat E, Moscoso D. 2014. Prebiotics and probiotics in irritable bowel syndrome and inflammatory bowel disease in children. Benef Microbes. 12: 1—9.

4. Goodrich JK, Waters JL, Poole AC. 2014. Human genetics shape the gut microbiome. Cell. 159;4: 789—799. http://dx.doi.org/10.1016/j.cell.2014.09.053; PMid:25417156 PMCid:PMC4255478

5. Hoa N, Prasadb V. 2013. Probiotics, prebiotics, synbiotics and naturally fermented foods: why more may be more. Ann Gastroenterol. 26;3: 277—278.

6. Tojo R, Suarez A, Clemente MG et al. 2014. Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis. World J Gastroenterol. 20;41: 15163—15176. http://dx.doi.org/10.3748/wjg.v20.i41.15163; PMid:25386066 PMCid:PMC4223251

7. Jirillo E, Jirillo F, Magrone T. 2012. Healthy effects exerted by prebiotics, probiotics, and symbiotics with special reference to their impact on the immune system. Int J Vitam Nutr Res. 82;3: 200—208. http://dx.doi.org/10.1024/0300-9831/a000112; PMid:23258401

8. Lawley TD, Walker AW. 2013. Intestinal colonization resistance. The Journal of cells, molecules, systems and technologies. Immunology. 138;1: 1—11. http://dx.doi.org/10.1111/j.1365-2567.2012.03616.x; PMid:23240815 PMCid:PMC3533696

9. Mai V, Draganov PV. 2009. Recent advances and remaining gaps in our knowledge of associations between gut microbiota and human health. World J Gastroenterol. 15;1: 81—85. http://dx.doi.org/10.3748/wjg.15.81; PMid:19115471

10. Valles Y, Gosalbes MJ, de Vries LE et al. 2012. Metagenomics and development of the gut microbiota in infants. Clin Microbiol Infect. 18; Suppl 4: 21—26. http://dx.doi.org/10.1111/j.1469-0691.2012.03876.x; PMid:22647043

11. Timmerman HM, Koning CJ, Mulder L et al. 2004. Monostrain, multistrain and multispecies probiotics — A comparison of functionality and efficacy. Int J Food Microbiol. 96;3: 219—233. http://dx.doi.org/10.1016/j.ijfoodmicro.2004.05.012; PMid:15454313

12. Neu J. 2014. The developing intestinal microbiome: probiotics and prebiotics. World Rev Nutr Diet. 110: 167—176. http://dx.doi.org/10.1159/000358465; PMid:24751628

13. Oelschlaeger TA. 2010. Mechanisms of probiotic actions — A review. Int J Med Microbiol. 300: 57—62. http://dx.doi.org/10.1016/j.ijmm.2009.08.005; PMid:19783474

14. Capitan-Canadas F, Ortega-Gonzalez M, Guadix E et al. 2014. Prebiotic oligosaccharides directly modulate proinflammatory cytokine production in monocytes via activation of TLR4. Mol Nutr Food Res. 58;5: 1098—1110. http://dx.doi.org/10.1002/mnfr.201300497; PMid:24549946

15. Petschow B, Dore J, Hibberd P et al. 2013. Probiotics, prebiotics, and the host microbiome: the science of translation. Ann N Y Acad Sci. 1306: 1—17. http://dx.doi.org/10.1111/nyas.12303; PMid:24266656 PMCid:PMC4013291

16. Rastall RA, Gibson GR. 2015. Recent developments in prebiotics to selectively impact beneficial microbes and promote intestinal health. Curr Opin Biotechnol. 32: 42—46. http://dx.doi.org/10.1016/j.copbio.2014.11.002; PMid:25448231

17. Sokol H, Seksik P. 2010. The intestinal microbiota in inflammatory bowel diseases: time to connect with the host. Curr Opin Gastroenterol. 26;4: 327—331. http://dx.doi.org/10.1097/MOG.0b013e328339536b

18. Suvorov A. 2013. Gut microbiota, probiotics, and human health. Biosci Microbiota Food Health. 32;3: 81—91. http://dx.doi.org/10.12938/bmfh.32.81; PMid:24936366 PMCid:PMC4034364

19. Koning CJ, Jonkers D, Smidt H et al. 2010. The effect of a multispecies probiotic on the composition of the faecal microbiota and bowel habits in chronic obstructive pulmonary disease patients treated with antibiotics. Br J Nutr. 103;10: 1452—1460. http://dx.doi.org/10.1017/S0007114509993497; PMid:20021703

20. Catanzaro R, Anzalone M, Calabrese F et al. 2015. The gut microbiota and its correlations with the central nervous system Disorders. Panminerva Med. 57;3: 127—143. PMid:25390799

21. Soccol CR, Vandenberghe LPS, Spier MR et al. 2010. The Potential of Probiotics. Food Technol Biotechnol. 48;4: 413—434.

22. Walker WA. 2013. Initial intestinal colonization in the human infant and immune homeostasis. Ann Nutr Metab. 63; Suppl 2: 8—15. http://dx.doi.org/10.1159/000354907; PMid:24217032

23. Kelly D, Mulder IE. 2012. Microbiome and immunological interactions. Nutr Rev. 70; Suppl 1: 18—30. http://dx.doi.org/10.1111/j.1753-4887.2012.00498.x; PMid:22861803