• Ultrastructural characteristics of different clinical and pathogenetic variants of uterine leiomyoma

Ultrastructural characteristics of different clinical and pathogenetic variants of uterine leiomyoma

HEALTH OF WOMAN. 2018.2(128):94–99; doi 10.15574/HW.2018.128.94

Kosey N. V.
SI «Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine», Kiev

The objective: to study the ultrastructural features of the structure of uterine leiomyoma (LM) in cases of its isolated growth and connected with the pathology of the thoracic and thyroid glands.
Materials and methods. An electron microscopic study was carried out on remote females of 111 women with LM. Of them, 36 women – with isolated LM (group I), 23 patients – with a combination of LM and breast dyshormonal diseases (II group), in 27 women – with a combination of the above pathology of the uterus and diseases of the thyroid gland (III group) and in 25 patients – with a combination of LM, DZGZH and thyroid pathology (group IV), who underwent radical hysterectomy for indications.
Results. The general changes inherent in LM have been revealed at the ultrastructural level in the form of hypertrophy of smooth muscle cells with the intensification of metabolic processes in them, an increase in the synthetic function of cells and hypercooperative myocytes.
The peculiarity of the isolated development of LM was changes in the organelles in myocytes of a degenerative-destructive nature against the background of pronounced pericellular fibrosis, whereas in cases of a combination of fibroids and the pathology of the thoracic or thyroid glands, a significant increase in the number of energy and plastic organelles (mitochondria, ribosomes and endoplasmic reticulum) hypercooperative cells. In the cases of a combination of dyshormonal pathology of the uterus, thoracic and thyroid glands, the most pronounced ultrastructural changes are revealed, indicating intensification of energy and plastic metabolism, an increase in the synthesis of contractile proteins and an increase in the proliferative potential of the cells along with the gradual processes of death of certain myocytes.
Conclusion. The results of this study are the basis for the development of differentiated tactics for the management of uterine leiomyoma in various clinical and pathogenetic variants of its development.
Key words: uterine leiomyoma, pathology of the thoracic and thyroid glands, electron microscopy, ultrastructural changes, myocyte, organelles, pericellular fibrosis, degenerative-destructive changes.


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