• Therapy of reproductive disorders from the point of oxidative stress overcoming

Therapy of reproductive disorders from the point of oxidative stress overcoming

HEALTH OF WOMAN. 2018.10(136):26–29; doi 10.15574/HW.2018.136.26

Pyrohova V. I. , Shurpyak S. A. , Oshurkevich A. A.
Lviv national medical University named Danylo Galitsky

In many pathological conditions, the level of production of oxygen radicals exceeds the neutralizing ability of antioxidant protection, which leads to the development of oxidative stress. The intensity of lipid peroxidation processes depends on the severity of the pathological process, and the pathophysiological significance of free radicals is primarily associated with their effect on the structural state and function of biological membranes. Based on the mechanisms of development of oxidative stress and its consequences, effective therapy should be focused on key pathogenesis.

The purpose of the study is to evaluate the effectiveness of the use of natural vitamin E (Enat 400) in patients with inflammatory diseases of the genital organs and reproductive losses in history at the stage of preconception care.

Materials and methods. Under the supervision there were 65 women aged from 22 to 35 years with a burdened obstetric and gynecological history (PID and miscarriage). The main group consisted of 40 patients who were administered on the basis of the preconception algorithm using the Enat 400 antioxidant in accordance with the phases of the MC, micronized progesterone preparations, and 4,000 IU colecalciferol in the serum blood serum level below 30 ng/ml; comparison group – 25 women who received traditional preconception therapy.

Results. For women with impaired reproductive function, there is a pronounced imbalance of the LP-AOS, which is manifested by a decrease in the activity of the antioxidant defense link and the intensification of lipid peroxidation processes (activation of free-radical reactions with manifestations of oxidative stress).

Conclusion. The use of natural vitamin E containing 400 IU D-alpha-tocopheryl acetate (Enat 400) in the preconception complex allows not only to overcome oxidative stress, but also to improve reproductive results by 3.85 times.

Key words: oxidative stress, pelvic inflammatory diseases, miscarriage, antioxidants, vitamin E, Enat 400.


1. Dobrohotova YuE, Ivanova TA, Gulyaeva NV i dr. (2008). Okislitelnyiy stress v platsente pri fiziologicheskoy i patologicheski protekayuschey beremennosti. Ros. vestn. akushera-ginekologa 6:33–6.

2. Zenkov NK, Lankin VZ, Menschikova EB. (2001). Okislitelnyiy stress: Biohimicheskiy i patofiziologicheskiy aspekty. M, MAIK «Nauka/Interperiodika»:343.

3. Kurashvili VA, Maylem L. (2001). Novyie vozmozhnosti predotvrascheniya oksidativnogo stressa. Zhurnal naturalnoy meditsinyi 1:7-14.

4. Luschak VI. (2001). Okislitelnyiy stress i mehanizmyi zaschityi ot nego. Biohimiya 66(5):592–609.

5. Menschikova EB, Zenkov NK, Lankin VZ i dr. (2008). Okislitelnyiy stress: Patologicheskie sostoyaniya i zabolevaniya. Novosibirsk, ARTA:284.

6. Rebrov VG. (2003). Vitaminyi i mikroelementyi. M, ALEV-V:670.

7. Sazontova TG, Arhipenko YuV. (2007). Znachenie balansa prooksidantov i antioksidantov – ravnoznachnyih uchastnikov metabolizma. Patologich. fiziol. ekperim. terapiya 3:2–18.

8. Strizhakov AN, Ignatko IV. (2007). Poterya beremennosti. Meditsinskoe informatsionnoe agentstvo. Moskva:224.

9. Syirkasheva AG, Korotchenko OE. (2017). Okislitelnyiy stress. Antioksidantnaya terapiya pri pregravidarnoy podgotovke i/ili pri beremennosti. Meditsinskiy sovet 13:150-156.

10. Shalina RI, Kanzapetov MR. (2013). Antioksidantyi i ih rol v akusherskoy praktike. Ginekologiya 15(5):3–7.

11. Burton GJ, Jauniaux E. (2010). Oxidative stress. Best Practice & Research Clinical Obstetrics and Gynaecology. https://doi.org/10.1016/j.bpobgyn.2010.10.016

12. Mistry HD, Williams PJ. The importance of antioxidant micronutrients in pregnancy. Review article. Oxidative Medicine and Cellular Longevity Volume 2011. https://doi.org/10.1155/2011/841749

13. Ruder EH, Hartman TJ, Blumberg J, Goldman BM. (2008). Oxidative stress and antioxidants: exposure and impact on female fertility. Hum Reprod Update. 14(4):345–57. https://doi.org/10.1093/humupd/dmn011; PMid:18535004 PMCid:PMC2772106

14. Wiesenfeld HC, Hillier SL, Krohn MA et al. (2002). Lower genital tract infection and endometritis: insight into subclinical pelvic inflammatory disease. Obstet Gynecol. 100:456-463. https://doi.org/10.1016/S0029-7844(02)02118-X; https://doi.org/10.1097/00006250-200209000-00011; PMid:12220764