• Therapy of reproductive disorders from the point of oxidative stress overcoming
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Therapy of reproductive disorders from the point of oxidative stress overcoming

HEALTH OF WOMAN. 2018.10(136):26–29; doi 10.15574/HW.2018.136.26

Pyrohova V. I. , Shurpyak S. A. , Oshurkevich A. A.
Lviv national medical University named Danylo Galitsky

In many pathological conditions, the level of production of oxygen radicals exceeds the neutralizing ability of antioxidant protection, which leads to the development of oxidative stress. The intensity of lipid peroxidation processes depends on the severity of the pathological process, and the pathophysiological significance of free radicals is primarily associated with their effect on the structural state and function of biological membranes. Based on the mechanisms of development of oxidative stress and its consequences, effective therapy should be focused on key pathogenesis.

The purpose of the study is to evaluate the effectiveness of the use of natural vitamin E (Enat 400) in patients with inflammatory diseases of the genital organs and reproductive losses in history at the stage of preconception care.

Materials and methods. Under the supervision there were 65 women aged from 22 to 35 years with a burdened obstetric and gynecological history (PID and miscarriage). The main group consisted of 40 patients who were administered on the basis of the preconception algorithm using the Enat 400 antioxidant in accordance with the phases of the MC, micronized progesterone preparations, and 4,000 IU colecalciferol in the serum blood serum level below 30 ng/ml; comparison group – 25 women who received traditional preconception therapy.

Results. For women with impaired reproductive function, there is a pronounced imbalance of the LP-AOS, which is manifested by a decrease in the activity of the antioxidant defense link and the intensification of lipid peroxidation processes (activation of free-radical reactions with manifestations of oxidative stress).

Conclusion. The use of natural vitamin E containing 400 IU D-alpha-tocopheryl acetate (Enat 400) in the preconception complex allows not only to overcome oxidative stress, but also to improve reproductive results by 3.85 times.

Key words: oxidative stress, pelvic inflammatory diseases, miscarriage, antioxidants, vitamin E, Enat 400.


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