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The role of ecological and genetic factors in the onset of asthma in children (literature review) 

PERINATOLOGIYA I PEDIATRIYA. 2016.3(67):127-133; doi 10.15574/PP.2016.67.127 

The role of ecological and genetic factors in the onset of asthma in children (literature review) 

Chumachenko N. G.

SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv 

The article presents a literature review of publications domestic and foreign authors on the risk factors of the onset of asthma in children. Health is 20–40% dependent on the environment and 35–70% dependent on genetic factors. The interaction of genetic and environmental factors lead to anti-oxidant stress and changes not only on the level of the entire organism, but also on the cellular and molecular level. To asses to prognosis for onset and development of bronchial asthma in children, that reside in environmentally neglected zones it is necessary to continue the research into the molecular-genetic gene polymorphism of the enzymes of the xenobiotic detoxication system, as well as metabolic disturbances in children in order to delineate risk group for the onset of the condition and to develop indications for anti-oxidant treatment, to correct the molecular disturbances, that appear long before the clinical manifestation of asthma.

Key words: bronchial asthma, genetics of asthma, environment, children.


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